Patents Assigned to G. D. Searle
  • Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
    Patent number: 6887991
    Abstract: Processes for the preparation of 4,5-dihydro-5,7-lactone steroid compounds are provided.
    Type: Grant
    Filed: August 25, 2003
    Date of Patent: May 3, 2005
    Assignee: G. D. Searle & Company
    Inventors: John S. Ng, Chin Liu, Dennis K. Anderson, Jon P. Lawson, Joseph Wieczorek, Sastry A. Kunda, Leo J. Letendre, Mark J. Pozzo, Yuen-Lung L. Sing, Ping T. Wang, Edward E. Yonan, Richard M. Weier, Thomas R. Kowar, Julio A. Baez, Bernhard Erb
  • Cyclic sulfone containing retroviral protease inhibitors
    Patent number: 6875790
    Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
    Type: Grant
    Filed: February 20, 2003
    Date of Patent: April 5, 2005
    Assignees: G. D. Searle & Co., Pharmacia Corporation (Monsanto Corporation)
    Inventors: Deborah E. Bertenshaw, Daniel Getman, Robert M. Heintz, John J. Talley, Kathryn L. Reed, Robert Alan Chrusciel, Michael Clare
  • Immediate release eplerenone compositions
    Patent number: 6863902
    Abstract: The invention relates to oral pharmaceutical compositions useful as aldosterone receptor blockers comprising the active agent micronized eplerenone in an amount of about 10 mg to about 1000 mg and one or more carrier materials.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: March 8, 2005
    Assignee: G. D. Searle & Co.
    Inventors: Shilpa S. Thosar, Rajeev D. Gokhale, Dwain S. Tolbert
  • Substituted benzopyran derivatives for the treatment of inflammation
    Publication number: 20050049252
    Abstract: A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I? wherein X, A1, A2, A3, A4, R, R?, R1 and R2 are as described in the specification.
    Type: Application
    Filed: August 19, 2004
    Publication date: March 3, 2005
    Applicant: G.D. Searle & Co.
    Inventors: Jeffery Carter, Mark Obukowicz, Balekudru Devadas, John Talley, David Brown, Matthew Graneto, Stephen Bertenshaw, Donald Rogier, Srinivasan Nagarajan, Cathleen Hanau, Susan Hartmann, Cindy Ludwig, Suzanne Metz, Donald Korte
  • Substituted aromatic policyclic tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
    Patent number: 6861561
    Abstract: The invention relates to substituted aromatic polycyclic tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: March 1, 2005
    Assignee: G. D. Searle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Mark A. Massa, Jane L. Wang, Deborah A. Mischke, Barry L. Parnas, Melvin L. Rueppel
  • Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Patent number: 6861539
    Abstract: Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: March 1, 2005
    Assignee: G. D. Searle & Co.
    Inventors: Daniel P Getman, Gary A DeCrescenzo, John N Freskos, Michael L Vazquez, James A Sikorski, Balekudru Devadas, Srinivasan Raj Nagarajan, David L Brown, Joseph J McDonald
  • 1-phenyl imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders
    Patent number: 6858636
    Abstract: A class of 1-phenyl imidazol-2-one biphenylmethyl compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula wherein each of R1, R2 and R3 is independently selected from hydrido, alkyl, alkoxy, cyano, halo, hydroxy, carboxyl, alkoxycarbonyl, formyl and acetyl; alkylcarbonyl and haloalkylcarbonyl; with the proviso that at least one of R1, R2 and R3 must be a substituent other than hydrido, and with the further proviso that when each of R1 and R3 is hydrido, then R2 cannot be chloro; wherein R4 is hydrido; wherein R5 is alkyl; and wherein R6 is tetrazolyl; or a stereoisomer or a tautomer thereof or a pharmaceutically-acceptable salt thereof. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure.
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: February 22, 2005
    Assignee: G.D. Searle & Co.
    Inventors: David B. Reitz, Robert E. Manning
  • Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
    Patent number: 6858598
    Abstract: A method of using an MMP inhibitor and optionally radiation therapy, and one or more antineoplastic agents of the topoisomerase class selected from the group consisting of irinotecan and topotecan, as a combination therapy for the treatment of neoplasia is disclosed.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: February 22, 2005
    Assignee: G. D. Searle & Co.
    Inventors: John P. McKearn, Gary Gordon, James J. Cunningham, Stephen T. Gately, Alane T. Koki, Jaime L. Masferrer
  • 2-Amino-benzoxazinones for the treatment of herpes simplex virus
    Publication number: 20050032795
    Abstract: 2-Amino-benzoxazinones are identified for use in the treatment of Herpes Simplex Virus. A subject is treated for Herpes Simplex Virus by treating with an effective amount of 2-amino-benzoxazinones.
    Type: Application
    Filed: September 13, 2004
    Publication date: February 10, 2005
    Applicants: G.D. Searle & Co., Asahi Chemical Industry Co., Ltd.
    Inventors: Masashi Kawanishi, Wataru Takahashi
  • 2-amino-benzoxazinones for the treatment of viral infections
    Publication number: 20050032793
    Abstract: A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-R4 are as defined herein, or a pharmaceutically-acceptable salt thereof.
    Type: Application
    Filed: December 8, 2003
    Publication date: February 10, 2005
    Applicant: G.D. Searle & Co.
    Inventors: Norman Abood, Daniel Flynn, Daniel Becker, Brian Bax, Hui Li, Roger Nosal, Lori Schretzman, Clara Villamil
  • Pyrazole derivatives as p38 kinase inhibitors
    Patent number: 6852740
    Abstract: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula I wherein Q, R1, R2, R3 and R4 are as described in the specification.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: February 8, 2005
    Assignee: G. D. Searle & Co.
    Inventors: Gunnar J. Hanson, Shuyuan Liao
  • Method of preparing retroviral protease inhibitor intermediates
    Patent number: 6849760
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: February 1, 2005
    Assignee: G. D. Searle & Co.
    Inventors: John S Ng, Claire S Przybyla, Shu-Hong Zhang
  • ?- and ?-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: 6846954
    Abstract: ?- and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: January 25, 2005
    Assignee: G. D. Searle & Co.
    Inventors: Michael L Vazquez, Richard A. Mueller, John J. Talley, Daniel P Getman, Gary A. DeCrescenzo, John N. Freskos, Robert M. Heintz, Deborah E. Bertenshaw
  • Dihydrobenzopyrans, dihydrobenzothiopyrans, and tetrahydroquinolines for the treatment of COX-2-mediated disorders
    Publication number: 20050010050
    Abstract: A class of dihydrobenzopyrans, dihydrobenzothiopyrans, tetrahydroquinolines, tetrahydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula (I) wherein X, A1, A2, A3, A4, R, R?, R1 and R2 are as described in the specification.
    Type: Application
    Filed: August 2, 2004
    Publication date: January 13, 2005
    Applicant: G.D. Searle & Co.
    Inventors: Donald Rogier, Jeffery Carter, John Talley
  • Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Publication number: 20050004043
    Abstract: Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: February 24, 2004
    Publication date: January 6, 2005
    Applicant: G.D. Searle & Co.
    Inventors: Michael Vazquez, Richard Mueller, John Talley, Daniel Getman, Gary DeCrescenzo, John Freskos
  • Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Publication number: 20040267022
    Abstract: Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: January 2, 2004
    Publication date: December 30, 2004
    Applicant: G. D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • DNA clone of human tissue factor inhibitor
    Publication number: 20040265981
    Abstract: A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined.
    Type: Application
    Filed: July 9, 2004
    Publication date: December 30, 2004
    Applicant: G. D. SEARLE & CO.
    Inventors: Tze Chein Wun, Kuniko K. Kretzmer, George J. Broze
  • Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Publication number: 20040260095
    Abstract: Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Application
    Filed: January 20, 2004
    Publication date: December 23, 2004
    Applicant: G. D. Searle & Co.
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Michael L. Vazquez, James A. Sikorski, Balekudru Devadas, Srinivasan Nagarajan, David L. Brown, Joseph J. McDonald
  • Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
    Patent number: 6833373
    Abstract: The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of an integrin antagonist and an antineoplastic agent.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: December 21, 2004
    Assignee: G.D. Searle & Co.
    Inventors: John P. McKearn, Gary Gordon, James J. Cunningham, Stephen T. Gately, Alane T. Koki, Jaime L. Masferrer
  • Pyrimidine compounds and derivatives thereof
    Patent number: 6831199
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, wherein A is pharmaceutical compositions thereof and methods of using such compounds and compositions as &agr;v&bgr;3 antagonists.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: December 14, 2004
    Assignee: G. D. Searle & Co.
    Inventors: Peter Gerrard Ruminski, Michael Clare, Paul Waddell Collins, Bipinchandra Nanubhai Desai, Richard John Lindmark, Joseph Gerace Rico, Thomas Edward Rogers, Mark Andrew Russell