Abstract: The invention concerns substituted pyrrole compounds and their pharmaceutical applications. The compounds of the invention are potent inhibitors of lipoxygenase and cyclo-oxygenase and therefore are suitable to treat the set of rheumatic illnesses and to prevent allergically induced ailments. The compounds have the general formula: ##STR1## where R.sup.1 denotes a C.sub.1 -C.sub.12 alkyl group, R.sup.2 denotes a hydrogen atom or a C.sub.1 -C.sub.12 alkyl group, or R.sup.1 and R.sup.2 together with the carbon atom and the nitrogen atom to which they are bound form a ring of 5 to 8 links which may contain a sulfur heteroatom or a carbonyl group and may be substituted with one or two C.sub.1 -C.sub.4 alkyl groups,each time two of the residues R.sup.3, R.sup.4 and R.sup.5 independently from one another represent a hydrogen atom, a C.sub.5 -C.sub.8 cycloalkyl group, a C.sub.1 -C.sub.12 alkyl group or an aryl group which may be substituted by one or two residues selected from a halogen atom, a nitro-, a C.sub.1 -C.