Patents Assigned to G. Gaslini Children's Hospital
  • Tumor-targeted drug delivery systems and uses thereof
    Publication number: 20090092663
    Abstract: The present invention relates to targeted delivery systems for delivering therapeutic agents to tumor. The invention further relates to methods of delivering a therapeutic agent to a tumor for the prevention and treatment of cancer by killing tumor cells and tumor-associated endothelial cells. In particular, the present invention provides a tumor-targeted drug delivery system comprising a NGR-containing molecule linked to a delivery vehicle encapsulating a therapeutic agent, preferably a drug, such as a cytotoxic agent or a chemotherapeutic agent. Specifically, the delivery systems of the present invention are capable of delivering an increased amount of therapeutic agent to a tumor as compared to other delivery systems.
    Type: Application
    Filed: August 29, 2008
    Publication date: April 9, 2009
    Applicants: G. Gaslini Children's Hospital, Fondazione Centro San Raffaele Del Monte Tabor, The Governors of the University of Alberta
    Inventors: Mirco Ponzoni, Angelo Corti, Theresa M. Allen
  • Tumor-targeted drug delivery systems and uses thereof
    Patent number: 7479483
    Abstract: The present invention relates to targeted delivery systems for delivering therapeutic agents to tumor. The invention further relates to methods of delivering a therapeutic agent to a tumor for the prevention and treatment of cancer by killing tumor cells and tumor-associated endothelial cells. In particular, the present invention provides a tumor-targeted drug delivery system comprising a NGR-containing molecule linked to a delivery vehicle encapsulating a therapeutic agent, preferably a drug, such as a cytotoxic agent or a chemotherapeutic agent. Specifically, the delivery systems of the present invention are capable of delivering an increased amount of therapeutic agent to a tumor as compared to other delivery systems.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: January 20, 2009
    Assignees: G. Gaslini Children's Hospital, Fondazione Centro San Raffaele del Monte, University of Alberta
    Inventors: Mirco Ponzoni, Angelo Corti, Theresa M. Allen