Abstract: Disclosed is an abuse-deterrent pharmaceutical composition comprising a drug with an enzyme-reactive functional group, wherein the drug has an abuse potential, and an enzyme capable of reacting with the enzyme-reactive functional group (a drug-processing enzyme), wherein the drug with the enzyme-reactive functional group is contained in the pharmaceutical composition in a storage stable, enzyme-reactive state and under conditions wherein no enzymatic activity acts on the drug.
Type:
Grant
Filed:
February 28, 2017
Date of Patent:
August 3, 2021
Assignee:
G.L. PHARMA GMBH
Inventors:
Georg Guebitz, Katrin Greimel, Martin Brandauer, Daniela Huber, Klaus Bleymaier, Wolfgang Kroutil, Doris Lechner, Christof Wachter, Harald Wagner, Heimo Winkler
Abstract: Disclosed are pharmaceutical compositions comprising oxycodone and an oxycodone-processing enzyme, wherein oxycodone is contained in the pharmaceutical composition in a storage stable, enzyme-reactive state and under conditions wherein no enzymatic activity acts on oxycodone.
Type:
Application
Filed:
April 9, 2020
Publication date:
August 20, 2020
Applicant:
G.L. PHARMA GMBH
Inventors:
Georg GUEBITZ, Katrin Greimel, Martin Brandauer, Daniela Huber, Klaus Bleymaier, Wolfgang Kroutil, Doris Lechner, Christof Wachter, Harald Wagner, Heimo Winkler
Abstract: Disclosed are pharmaceutical compositions comprising oxycodone and an oxycodone-processing enzyme, wherein oxycodone is contained in the pharmaceutical composition in a storage stable, enzyme-reactive state and under conditions wherein no enzymatic activity acts on oxycodone.
Type:
Grant
Filed:
February 28, 2017
Date of Patent:
July 7, 2020
Assignee:
G.L. PHARMA GMBH
Inventors:
Georg Guebitz, Katrin Greimel, Martin Brandauer, Daniela Huber, Klaus Bleymaier, Wolfgang Kroutil, Doris Lechner, Christof Wachter, Harald Wagner, Heimo Winkler
Abstract: Disclosed are pharmaceutical compositions comprising a drug with a laccase-reactive functional group and a laccase (EC.10.3.2) and methods for manufacturing such compositions.
Type:
Application
Filed:
February 28, 2017
Publication date:
March 7, 2019
Applicant:
G. L. PHARMA GMBH
Inventors:
Georg GUEBITZ, Katrin GREIMEL, Martin BRANDAUER, Daniela HUBER, Klaus BLEYMAIER, Wolfgang KROUTIL, Doris LECHNER, Christof WACHTER, Harald WAGNER, Heimo WINKLER
Abstract: Disclosed is an abuse-deterrent pharmaceutical composition comprising a drug with an enzyme-reactive functional group, wherein the drug has an abuse potential, and an enzyme capable of reacting with the enzyme-reactive functional group (a drug-processing enzyme), wherein the drug with the enzyme-reactive functional group is contained in the pharmaceutical composition in a storage stable, enzyme-reactive state and under conditions wherein no enzymatic activity acts on the drug.
Type:
Application
Filed:
February 28, 2017
Publication date:
February 28, 2019
Applicant:
G.L. PHARMA GMBH
Inventors:
Georg GUEBITZ, Katrin GREIMEL, Martin BRANDAUER, Daniela HUBER, Klaus BLEYMAIER, Wolfgang KROUTIL, Doris LECHNER, Christof WACHTER, Harald WAGNER, Heimo WINKLER
Abstract: Disclosed are pharmaceutical compositions comprising oxycodone and an oxycodone-processing enzyme, wherein oxycodone is contained in the pharmaceutical composition in a storage stable, enzyme-reactive state and under conditions wherein no enzymatic activity acts on oxycodone.
Type:
Application
Filed:
February 28, 2017
Publication date:
February 28, 2019
Applicant:
G.L. PHARMA GMBH
Inventors:
Georg GUBITZ, Katrin GREIMEL, Martin BRANDAUER, Daniela HUBER, Klaus BLEYMAIER, Wolfgang KROUTIL, Doris LECHNER, Christof WACHTER, Harald WAGNER, Heimo WINKLER
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