Abstract: The specification discloses an improved multiple suture stapler in which two rows of staples are pushed by a comb-like ram out of a magazine of a frame and are clinched by an anvil releasably latched to the frame. The frame is of one-piece plastic construction and includes a pair of handles hinged to the magazine and having forwardly projecting, hinged arms welded to a push rod connected to the ram. One of the handles has a thumb grip used when the anvil is closed on the magazine. A stapler forming an alternate embodiment of the invention includes a latching rod splined to a frame with a thumb grip serving to push the latching rod into a latch mechanism of an anvil, and also adapted to be manually turned to turn the rod to a latch releasing position.