Abstract: A metabolite monitoring system comprising a microdialysis probe including a semi-permeable membrane and a probe flow path passing from an inlet through a sensing volume adjacent to said semi-permeable membrane to an outlet, a fluid delivery device for delivering dialysate to said inlet; and a metabolite monitoring system associated with said outlet for monitoring a concentration of at least one metabolite in said dialysate from said microdialysis probe, wherein said fluid delivery device is configured to deliver a pulsed flow of said dialysate to said inlet.

Abstract: A pressurized reservoir system for storing and dispensing a plurality of liquids in very small quantities in which the liquids are dispensed independently from each other and also together in fixed volumetric proportions.

Abstract: A device for monitoring a constituent of body fluid continuously or repeatedly over a time period includes a body fluid sampling system and an optical sensor arrangement. The sampling system has a pumping arrangement which pumps body fluid from a cannula to a fluid sink. The optical sensor determines a concentration of at least one constituent of the body fluid. The pumping arrangement preferably ejects drops of body fluid from a fine nozzle. According to certain embodiments, optical sensor arrangements ensure that the optical paths do not pass through surfaces wetted by the fluid to be examined.

Abstract: Systems and methods for monitoring the concentration of glucose or other metabolites by way of a low-volume microdialysis-probe (10) operative in accordance with a pulsed mode of flow through a flow path (12) defined by a layered structure. Also described are a system and a method for deployment of the microdialysis probe (10) within the body and a technique for deriving a metabolite concentration of the basis of a rate of change of an optical parameter.

Abstract: A metabolite monitoring system comprising a microdialysis probe including a semi-permeable membrane and a probe flow path passing from an inlet through a sensing volume adjacent to said semi-permeable membrane to an outlet, a fluid delivery device for delivering dialysate to said inlet; and a metabolite monitoring system associated with said outlet for monitoring a concentration of at least one metabolite in said dialysate from said microdialysis probe, wherein said fluid delivery device is configured to deliver a pulsed flow of said dialysate to said inlet.

Abstract: A device for monitoring a constituent of body fluid continuously or repeatedly over a time period includes a body fluid sampling system and an optical sensor arrangement. The sampling system has a pumping arrangement which pumps body fluid from a cannula to a fluid sink. The optical sensor determines a concentration of at least one constituent of the body fluid. The pumping arrangement preferably ejects drops of body fluid from a fine nozzle. According to certain embodiments, optical sensor arrangements ensure that the optical paths do not pass through surfaces wetted by the fluid to be examined.