Abstract: Disclosed are a method for computer-assisted evaluation of biomarkers in a tissue sample as well as a corresponding system and computer program. The method includes the following steps: providing an image of the tissue sample in which cell nuclei of the tissue as well as biomarkers are represented, automatically determining for a plurality of locations or regions within the image a blood vessel probability that represents a probability that the image at the corresponding location or region represents a blood vessel, automatically determining an assumed blood vessel location within the image based on a distribution of blood vessel probability with respect to the locations or regions within the image, automatically selecting biomarkers represented in the image at locations outside the assumed blood vessel location but within a threshold distance from the assumed blood vessel location, and automatically evaluating the selected biomarkers.
Type:
Grant
Filed:
September 19, 2018
Date of Patent:
February 1, 2022
Assignees:
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts, Brandenburgische Technische Universität Cottbus-Senftenberg, GA Generic Assays GmbH
Inventors:
Cläre Von Neubeck, Rico Hiemann, Alexey Elimport
Abstract: The invention relates to a method for the detection of antibodies from body fluids via immune reaction with GP2 from pancreatic zymogenic granules, immunoreactive sequences or analogs thereof, excluding tissue sections.