Patents Assigned to GAIN THERAPEUTICS SA
  • COMBINATION THERAPY FOR TREATING MPS1
    Publication number: 20230140216
    Abstract: The application is directed to compounds of formula (I) and their salts and solvates, wherein B, R1, R2, R3, R3’, R4, R4’ and R5 are as set forth in the specification, as well as to methods for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of, e.g., MPS1, optionally in combination with ?-L-iduronidase or an analog or variant thereof, e.g., laronidase.
    Type: Application
    Filed: February 3, 2021
    Publication date: May 4, 2023
    Applicant: GAIN THERAPEUTICS SA
    Inventors: Ana Maria GARCÍA COLLAZO, Elena CUBERO JORDÀ, Xavier BARRIL ALONSO, Roberto MAJ, Natalia PEREZ CARMONA
  • HETEROARYL COMPOUNDS AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF BETA-GLUCOCEREBROSIDASE
    Publication number: 20230107499
    Abstract: The application is directed to compounds of formulae (IA) and (IB) and their salts and solvates, wherein R1a, R2a, R3a, A1, A2, A3, R1b, R2b, R3b, B1, and B2 are as set forth in the specification, as well as to methods for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of, e.g., lysosomal storage diseases, such as Gaucher's disease, and ?-synucleinopathies, such as Parkinson's disease.
    Type: Application
    Filed: November 25, 2020
    Publication date: April 6, 2023
    Applicant: GAIN THERAPEUTICS SA
    Inventors: Ana Maria GARCÍA COLLAZO, Elena CUBERO JORDÀ, Manolo BELLOTTO, Enrique FERNÁNDEZ IGLESIAS
  • ARYL AND HETEROARYL COMPOUNDS, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF GALACTOCEREBROSIDASE
    Publication number: 20230058312
    Abstract: The application is directed to compounds of formulae (IA) and (IB): (IA) and (IB), and their salts and solvates, wherein R1a, R2a, A1, A2, A3, A4, R1b, R2b, B1, B2, B3, and G are as set forth in the specification, as well as to methods for their preparation, N pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of, e.g., lysosomal storage diseases, such as Krabbe's disease, and ?-synucleinopathies, such as Parkinson's disease.
    Type: Application
    Filed: November 25, 2020
    Publication date: February 23, 2023
    Applicant: GAIN THERAPEUTICS SA
    Inventors: Ana Maria GARCÍA COLLAZO, Elena CUBERO JORDÀ, Xavier BARRIL ALONSO, Manolo BELLOTTO