Patents Assigned to Galapagos SAS
  • Recombinant cell lines for the stable and high-level production of biologically active Dkk1 protein
    Patent number: 8158417
    Abstract: This invention relates to the use of specific recombinant cell lines in order to produce biologically active DKK1 protein in a stable and high-level manner. The invention also relates to these recombinant cell lines, as well as a method for stable and high-level production of biologically active DKK1 protein, implementing such recombinant cell lines.
    Type: Grant
    Filed: October 20, 2006
    Date of Patent: April 17, 2012
    Assignee: Galapagos SAS
    Inventors: Patrick Mollat, Corinne Gillard
  • Methods for the use of pyrimidine derivatives which are antagonists of vitronectin receptor
    Patent number: 7846932
    Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: December 7, 2010
    Assignee: Galapagos SAS
    Inventors: Jean-Michel Lefrancois, Bertrand Heckmann
  • Pyrimidine derivatives which are antagonists of vitronectin receptor
    Patent number: 7825119
    Abstract: A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: November 2, 2010
    Assignee: Galapagos SAS
    Inventors: Jean-Michel Lefrancois, Bertrand Heckmann
  • Vitronectin receptor antagonist derivatives, method for preparing same, use thereof as medicines and pharmaceutical compositions containing same
    Patent number: 7763621
    Abstract: A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: July 27, 2010
    Assignee: Galapagos SAS
    Inventors: Jean-Marie Ruxer, Jean-Michel Lefrancois, Bertrand Heckmann
  • Vitronectin receptor antagonist derivatives, method for preparing same, use thereof as medicines and pharmaceutical compositions containing same
    Patent number: 7582640
    Abstract: A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: September 1, 2009
    Assignee: Galapagos SAS
    Inventors: Jean-Marie Ruxer, Jean-Michel Lefrancois, Bertrand Heckmann
  • Recombinant Cell Lines for the Stable and High-Level Production of Biologically Active Dkk1 Protein
    Publication number: 20080248526
    Abstract: This invention relates to the use of specific recombinant cell lines in order to produce biologically active DKK1 protein in a stable and high-level manner. The invention also relates to these recombinant cell lines, as well as a method for stable and high-level production of biologically active DKK1 protein, implementing such recombinant cell lines.
    Type: Application
    Filed: October 20, 2006
    Publication date: October 9, 2008
    Applicant: Galapagos SAS
    Inventors: Patrick Mollat, Corinne Gillard