Abstract: A closure for a container including a base having a passageway extending therethrough. At least a portion of the base is configured to attach to at least a portion of an opening of a container such that the passageway is in registry with at least a portion of the opening. A cap is movably attached to the base. The cap is movable between a first position in which at least a portion of the cap blocks at least a portion of the passageway and a second position in which the cap is spaced-apart from at least a portion of the passageway to allow contents from within the container to pass therethrough. A seal is positioned on one of the cap and the base.

Abstract: A closure for a container including a base having a passageway extending therethrough. At least a portion of the base is configured to attach to at least a portion of an opening of a container such that the passageway is in registry with at least a portion of the opening. A cap is movably attached to the base. The cap is movable between a first position in which at least a portion of the cap blocks at least a portion of the passageway and a second position in which the cap is spaced-apart from at least a portion of the passageway to allow contents from within the container to pass therethrough. A seal is positioned on one of the cap and the base.

Abstract: A combination includes a child-resistant package and a collapsible tube removably positionable therein. A sidewall of a body of the package has an interior surface and an opposing exterior surface. A cavity is defined by the body. An opening is positioned proximate an open first end of the body. A bottom wall is positioned proximate an open second end of the body. A cap is removably mounted onto at least a portion of the first end of the body. The collapsible tube is surrounded by the body, the bottom wall and the cap when the cap is mounted onto at least a portion of the first end of the body. The collapsible tube includes a generally flexible housing defining a cavity for holding a substance to be dispensed from the housing. A closure is removably mounted onto the housing.

Abstract: A combination includes a container having a body with a first end and a second end. The body defines a cavity for holding contents to be dispensed from the container. An actuator is positioned proximate to the first end of the body. The actuator is operatively connected to the cavity to allow the contents to be dispensed therefrom. At least two diametrically opposed first fastening members are positioned on or in the body. A device has a generally open first end, a generally open second end, and a sidewall extending therebetween. The device is removably mountable onto the body of the container. At least two diametrically opposed second fastening members are positioned on or in an interior surface of the sidewall. Each second fastening member engages at least a portion of one of the first fastening members of the container when the device is mounted onto the container.

Abstract: Improved topical gel compositions for the treatment of skin disorders are described. The gel compositions contain carbomer and methylparaben, and are substantially free of methylparaben crystalline particles after an extended period of storage.

Abstract: Improved topical gel compositions for the treatment of skin disorders are described. The gel compositions contain carbomer and methylparaben, and are substantially free of methylparaben crystalline particles after an extended period of storage.

Abstract: Improved methods and compositions for safe and effective treatment of erythema or a symptom associated with erythema in a subject are described. The methods involve topically applying to an affected skin area a topical composition comprising about 0.4% to about 0.6% by weight of brimonidine and a pharmaceutically acceptable carrier.

Abstract: Improved topical gel compositions, such as those containing brimonidine, for the treatment of skin disorders are described. The gel compositions contain carbomer and methylparaben, and are substantially free of methylparaben crystalline particles after an extended period of storage.

Abstract: Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin.