Patents Assigned to Galileo Pharmaceuticals, Inc.
-
Patent number: 7119117Abstract: The present invention provides non-alpha-tocopherol enriched tocopherol compositions and non-alpha-tocopherol metabolite enriched compositions for use in the reduction of inflammatory markers associated with inflammation such as C-reactive protein.Type: GrantFiled: August 21, 2002Date of Patent: October 10, 2006Assignee: Galileo Pharmaceuticals, Inc.Inventors: Peggy Beinlich, Sekhar Boddupalli, Lesley A. Brown, Darlene M. Dreon, Stephen Flaim, Guy Miller, Stephen D. Phinney
-
Patent number: 7081476Abstract: Non-alpha-tocopherol enriched tocopherol compositions and non-alpha metabolite enriched compositions are disclosed for use in the reduction of the inflammatory marker IL-6.Type: GrantFiled: January 18, 2005Date of Patent: July 25, 2006Assignee: Galileo Pharmaceuticals, Inc.Inventors: Peggy Beinlich, Sekhar Boddupalli, Lesley A. Brown, Darlene M. Dreon, Stephen Flaim, Guy Miller, Stephen D. Phinney
-
Patent number: 7078541Abstract: Certain benzofuran derivatives are useful in the treatment of certain ischemic or inflammatory conditions, as well as neuroinflammation, neurodegeneration or degenerative diseases in which mitochondrial dysfunction leads to tissue degeneration. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.Type: GrantFiled: September 17, 2003Date of Patent: July 18, 2006Assignee: Galileo Pharmaceuticals, Inc.Inventors: Sekhar Boddupalli, Gail Walkinshaw, Bing Wang
-
Patent number: 7034054Abstract: The present invention provides method for the treatment of a symptom of neuronal damage associated with cerebral ischemia comprising administering gamma-, beta-, or delta-tocopherol enriched tocopherol compositions.Type: GrantFiled: December 14, 2001Date of Patent: April 25, 2006Assignee: Galileo Pharmaceuticals, Inc.Inventors: Guy Miller, Lesley A. Brown, Ughetta Del Balzo, Stephen Flaim, Sekhar Boddupalli, Bing Wang
-
Patent number: 6916850Abstract: Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes, amides, pyruvate analogues, modified pyruvate analogues, esters of pyruvate (e.g., polyol-pyruvate esters, pyruvate thioesters, glycerol-pyruvate esters and dihydroxyacetone-pyruvate esters). Such pyruvate derivatives (including single tautomers, single stereoisomers and mixtures of tautomers and/or stereoisomers, and the pharmaceutically acceptable salts thereof) are useful in the manufacture of pharmaceutical compositions for treating a number of conditions characterized by oxidative stress.Type: GrantFiled: May 3, 2002Date of Patent: July 12, 2005Assignee: Galileo Pharmaceuticals, Inc.Inventors: Bing Wang, Guy Miller, Wei Zhang
-
Patent number: 6900218Abstract: Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes, amides, pyruvate analogues, modified pyruvate analogues, esters of pyruvate (e.g., polyol-pyruvate esters, pyruvate thioesters, glycerol-pyruvate esters and dihydroxyacetone-pyruvate esters). Such pyruvate derivatives (including single tautomers, single stereoisomers and mixtures of tautomers and/or stereoisomers, and the pharmaceutically acceptable salts thereof) are useful in the manufacture of pharmaceutical compositions for treating a number of conditions characterized by oxidative stress.Type: GrantFiled: May 3, 2002Date of Patent: May 31, 2005Assignee: Galileo Pharmaceuticals, Inc.Inventors: Bing Wang, Guy Miller, Satyanarayana Janagani
-
Patent number: 6667330Abstract: Furanone derivatives and the pharmaceutically acceptable salts thereof have cytoprotective activity and protective activity for neuroinflammation, and neurodegenerative disorders; they are useful in the treatment of stroke, cerebral ischemia, myocardial infarction, myocardial ischemia, chronic heart failure, inflammation and other oxidative stress-related conditions, as well as Alzheimer's disease and senile dementia; they are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.Type: GrantFiled: January 28, 2003Date of Patent: December 23, 2003Assignee: Galileo Pharmaceuticals, Inc.Inventors: Bing Wang, Wei Zhang, Jiangao Song, Ughetta del Balzo, Lesley Brown, Gail Walkinshaw
-
Patent number: 6653346Abstract: Cytoprotective compounds, many of which are benzofuran derivatives are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.Type: GrantFiled: February 6, 2003Date of Patent: November 25, 2003Assignee: Galileo Pharmaceuticals, Inc.Inventors: Bing Wang, Jian Chen
-
Patent number: 6608196Abstract: Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.Type: GrantFiled: May 3, 2002Date of Patent: August 19, 2003Assignee: Galileo Pharmaceuticals, Inc.Inventors: Bing Wang, Satyanarayana Janagani, Wyeth B. Callaway, Jonathan L. Sessler