Patents Assigned to GALVANI BIOELECTRONICS LIMITED
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Patent number: 11944812Abstract: An extravascular neural interface includes a device containing electrodes for neurostimulation of a vessel. The devices are housed in flexible substrates forming two flaps, an inner flap having a spinal portion for routing leads/conductors into the device for connection to the electrodes and an outer flap that overlaps the inner flap. The inner flap supports and positions the electrodes to be inward facing, i.e., extravascular designs. The electrodes may be circular or elliptical and include a plurality of wings for securing the electrodes within a flap.Type: GrantFiled: May 9, 2022Date of Patent: April 2, 2024Assignee: GALVANI BIOELECTRONICS LIMITEDInventors: Faisal Zaidi, Sebastien Ouchouche
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Patent number: 11878160Abstract: The present invention provides devices and methods that can prevent or ameliorate bronchoconstriction by stimulating neural activity, in contrast to those techniques based on denervation, ablation or blocking of neural activity. Methods and devices according to the invention may act responsively or on demand, can preserve neuronal structure and function and will be associated with minimal collateral side-effects. In particular, the invention provides devices and methods in which a signal is delivered to the vagus nerve, for example the cervical vagus nerve or the pulmonary branch of the vagus nerve, in order to stimulate neural activity in the vagal nerve.Type: GrantFiled: August 18, 2016Date of Patent: January 23, 2024Assignee: Galvani Bioelectronics LimitedInventors: Michael John Carr, Kevin K. Kwong, Gerald E. Hunsberger
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Patent number: 11844952Abstract: Implantable systems are described that include a stimulation device positionable in vivo and configured to communicatively couple to electrodes configured to stimulate or block body tissue and an auxiliary device positionable in vivo and including one or more coils configured to wirelessly couple, in vivo, to the stimulation device and to wirelessly couple to an ex vivo device. The auxiliary device may include a coil driver and a power source controlled by a processor and memory for storing data instructions for the coil driver and for storing data received from the stimulation device. The auxiliary device may also include a radio transceiver and an antenna. The stimulation device may include a housing, a coil, a power source and an integrated circuit for controlling the electrodes. The stimulation device may be coupled to a cuff via a lead and physically coupled to the auxiliary device.Type: GrantFiled: February 1, 2021Date of Patent: December 19, 2023Assignee: Galvani Bioelectronics LimitedInventor: Rizwan Bashirullah
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Patent number: 11833356Abstract: An electrode system for neuromodulation and for recording of signals indicative of nerve activity is provided. The system can include a plurality of electrodes provided on a flexible, non-conductive substrate. The substrate can be rolled into a cuff for encircling a nerve bundle of a patient. The plurality of electrodes on the cuff can be interconnected using flexible conductors provided on the substrate. In one implementation, the electrodes can be interconnected using conductors that have spring-like configuration. Flexibility of the conductors allows the cuff to expand and contract with the nerve without causing excessive stress/strain at the nerve-cuff interface.Type: GrantFiled: February 17, 2017Date of Patent: December 5, 2023Assignee: GALVANI BIOELECTRONICS LIMITEDInventors: Bo Lu, Brian Marc Pepin
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Publication number: 20230381519Abstract: Modulation of neural activity of a subject's aortic depressor nerve (ADN) and/or carotid sinus nerve (CSN) can modulate baroreceptor reflex function, thereby providing ways of treating or preventing disorders associated with malfunction or loss of the baroreceptor reflex.Type: ApplicationFiled: January 24, 2023Publication date: November 30, 2023Applicants: CASE WESTERN RESERVE UNIVERSITY, Galvani Bioelectronics LimitedInventors: Arun SRIDHAR, Stephen J. LEWIS, Ibrahim SALMAN
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Patent number: 11752328Abstract: A neuromodulation apparatus for stimulating neural activity in a renal nerve of a patient is provided, the apparatus comprising a transducer Patient for applying a signal to the renal nerve so as to produce a physiological response. Methods of treating sleep apnoea are also provided, including methods using the neuromodulation apparatus.Type: GrantFiled: December 20, 2017Date of Patent: September 12, 2023Assignees: Galvani Bioelectronics Limited, Case Western Reserve UniversityInventors: Arun Sridhar, Alessandra Giarola, Stephen J. Lewis
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Patent number: 11745010Abstract: A nerve stimulation system including at least one nerve interface device is disclosed. The device includes a cuff portion having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first and second rings of electrodes mounted on the cuff portion, each ring of electrodes including a plurality of electrodes, and wherein each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The system includes a stimulation device in communication with the pairs of electrodes to generate different electrical signals for the pairs of electrodes and a control system that causes the different signals to causes different physiological responses.Type: GrantFiled: December 11, 2018Date of Patent: September 5, 2023Assignees: GALVANI BIOELECTRONICS LIMITED, UCL BUSINESS LTD.Inventors: Matteo Donega, Daniel Chew, David Holder, Kirill Aristovich
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Patent number: 11738196Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.Type: GrantFiled: July 25, 2022Date of Patent: August 29, 2023Assignee: Galvani Bioelectronics LimitedInventors: Margarita J. Vervoordeldonk, Eric Irwin, Daniel John Chew, Matteo Donega, Cindy Cleypool, Isha Gupta
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Patent number: 11724108Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.Type: GrantFiled: July 25, 2022Date of Patent: August 15, 2023Assignee: Galvani Bioelectronics LimitedInventors: Daniel John Chew, Matteo Donega, Isha Gupta
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Patent number: 11724102Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.Type: GrantFiled: July 25, 2022Date of Patent: August 15, 2023Assignee: Galvani Bioelectronics LimitedInventors: Matteo Donega, Daniel John Chew, Margarita J. Vervoordeldonk, Isha Gupta
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Publication number: 20230241396Abstract: The present invention provides an implantable neuromodulation system for delivering an electrical signal to a nerve to stimulate, inhibit or block conduction of action potentials in the nerve. The system comprises a neural interface device comprising first and second electrodes; a signal generator and a first closed-loop controller configured to generate a control signal based a property of the signal based on a measured voltage across the first and second electrodes, and cause the signal generator to adjust the electrical signal to modify the property of the signal.Type: ApplicationFiled: June 18, 2021Publication date: August 3, 2023Applicant: GALVANI BIOELECTRONICS LIMITEDInventors: Michael John CARR, Rizwan BASHIRULLAH
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Patent number: 11697026Abstract: An implant insertion system and methods of use of the implant insertion system are disclosed. The implant insertion system includes an implant and an instrument configured to deliver the implant to a biological structure and assist in deploying the implant to the biological structure. The instrument includes a retention member the secures the implant to the instrument and retains the implant in a first configuration. The retention member is movable to decouple the implant from the instrument. The implant is configured to transition from the first configuration to a second configuration, such that in the second configuration the implant is secured to the biological structure.Type: GrantFiled: December 14, 2018Date of Patent: July 11, 2023Assignee: GALVANI BIOELECTRONICS LIMITEDInventors: Benjamin Yaffe, Kenneth Douglas Rys
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Patent number: D994595Type: GrantFiled: February 16, 2022Date of Patent: August 8, 2023Assignee: Galvani Bioelectronics LimitedInventors: Jay Canham, David Lari, Cindy Au, Melissa Lara, Daniel Nobre, Ryan Jongwoo Choi
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Patent number: D994596Type: GrantFiled: February 16, 2022Date of Patent: August 8, 2023Assignee: Galvani Bioelectronics LimitedInventors: Jay Canham, David Lari, Cindy Au, Melissa Lara, Daniel Nobre, Ryan Jongwoo Choi
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Patent number: D994597Type: GrantFiled: February 16, 2022Date of Patent: August 8, 2023Assignee: Galvani Bioelectronics LimitedInventors: Jay Canham, David Lari, Cindy Au, Melissa Lara, Daniel Nobre, Ryan Jongwoo Choi
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Patent number: D998933Type: GrantFiled: October 25, 2019Date of Patent: September 19, 2023Assignee: GALVANI BIOELECTRONICS LIMITEDInventors: Morten Hansen, Jay Canham
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Patent number: D1001417Type: GrantFiled: October 25, 2019Date of Patent: October 17, 2023Assignee: GALVANI BIOELECTRONICS LIMITEDInventors: Morten Hansen, Jay Canham
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Patent number: D1009265Type: GrantFiled: June 24, 2021Date of Patent: December 26, 2023Assignee: GALVANI BIOELECTRONICS LIMITEDInventors: Peng Cong, Benjamin Yaffe, Morten Hansen
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Patent number: D1010973Type: GrantFiled: October 25, 2019Date of Patent: January 16, 2024Assignee: GALVANI BIOELECTRONICS LIMITEDInventors: Morten Hansen, Jay Canham
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Patent number: D1013324Type: GrantFiled: October 25, 2019Date of Patent: February 6, 2024Assignee: GALVANI BIOELECTRONICS LIMITEDInventors: Morten Hansen, Jay Canham