Patents Assigned to Gambro BCT, Inc.
  • Publication number: 20110077140
    Abstract: An apparatus for separating a volume of composite liquid into at least a first component and a second component comprising a centrifuge having a rotor with a turntable for supporting a separation bag; a central compartment for containing satellite bags, and fitted with a support member for supporting at least one satellite bag so that a liquid contained in the supported satellite bag drains from the supported satellite bag into the separation bag under centrifugation forces when the rotor is set in rotation.
    Type: Application
    Filed: August 14, 2006
    Publication date: March 31, 2011
    Applicant: GAMBRO BCT, INC.
    Inventors: Brian M. Holmes, Johan-Petter Hagström
  • Publication number: 20080314822
    Abstract: A device for loading a set of bags into the rotor of a centrifuge including a loading container having an annular rim extending outwardly such that the annular rim rests on the turn table of the rotor.
    Type: Application
    Filed: July 3, 2008
    Publication date: December 25, 2008
    Applicant: GAMBRO BCT, INC.
    Inventors: Brian M. Holmes, Johan-Petter (J-P) Hagstrom, Per-Olov Lundberg, Geert Van Waeg, Peter Nordgren
  • Publication number: 20080318756
    Abstract: A cell separation set for separating blood components, having a cell separation chamber with a first entry section having a wall with an outwardly flared curve, the entry section having an axial length and an inmost maximum diameter perpendicular to the axial length, the axial length being greater than the inmost maximum diameter. The cell separation chamber further comprises a separation section having a wall comprising an inward curve. A transition section between the entry section and the separation section has a wall comprising a second inward curve, the second inward curve being different from said first inward curve. The first curve may be tangent to the second curve at a first junction between the first and second curves and the second curve may be tangent to the third curve at a second junction between the second and third curves.
    Type: Application
    Filed: June 19, 2007
    Publication date: December 25, 2008
    Applicant: GAMBRO BCT, INC.
    Inventors: Robert W. Langley, Linda A. Taylor, Timothy Michael Taga
  • Publication number: 20080283781
    Abstract: The invention relates to an optical cell for a separation chamber of a density centrifuge blood processing system for separating fluid components comprising an extraction chamber having a first external optical surface for transmitting at least a portion of an incident optical beam; and an extraction port having an axial bore for passing fluid components and a first external optical surface for transmitting at least a portion of the incident optical beam; wherein said first external optical surface of said extraction chamber and said first external optical surface of said extraction port are both positioned within the depth of field of a light collection element.
    Type: Application
    Filed: July 7, 2008
    Publication date: November 20, 2008
    Applicant: GAMBRO BCT, INC.
    Inventors: Lee F. CARTER, Jeremy P. KOLENBRANDER, James R. LADTKOW, Joseph A. SCIBONA, Jeffrey A. STEWARD, Chris FLETCHER
  • Publication number: 20080283473
    Abstract: A method and apparatus related to using a squeezing or transfer fluid to transfer fluid or components between bags in a centrifuge wherein the squeezing fluid can be reversed to reduce squeezing and such fluid an also be used to build up a over-pressure for rapid movement.
    Type: Application
    Filed: October 31, 2007
    Publication date: November 20, 2008
    Applicant: GAMBRO BCT, INC.
    Inventors: Brian M. HOLMES, Peter PIHLSTEDT
  • Publication number: 20080254533
    Abstract: Cell expansion systems are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second fluid flow paths associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. The hollow fibers have a hydrophilic interior surface and a hydrophobic exterior surface. Detachable flow circuits are also provided.
    Type: Application
    Filed: April 14, 2008
    Publication date: October 16, 2008
    Applicant: Gambro BCT, Inc.
    Inventor: Glen Delbert Antwiler
  • Publication number: 20080248572
    Abstract: The present invention relates to treatment of polymeric bioreactor surfaces, to promote the proliferation of adherent cells.
    Type: Application
    Filed: March 5, 2008
    Publication date: October 9, 2008
    Applicant: GAMBRO BCT, INC.
    Inventor: Glen Delbert ANTWILER
  • Publication number: 20080234622
    Abstract: The present invention is related to pre-connected disposable sets including a pre-connected bag containing a photosensitizer for use in a blood separation and pathogen inactivation procedure.
    Type: Application
    Filed: March 20, 2007
    Publication date: September 25, 2008
    Applicant: GAMBRO BCT INC.
    Inventor: Dennis J. Hlavinka
  • Publication number: 20080227190
    Abstract: A disposable apparatus for cell expansion, having at least one bioreactor. The bioreactor has a cellular growth area and a supply area, the cellular growth area being adjacent a plate and separated from said supply area by a membrane. The bioreactor comprises a plurality of plates. The plates have a roughened surface or a corrugated surface. At least a sheet of membrane separates adjacent plates. Two sheets between adjacent plates may be separated by a mesh.
    Type: Application
    Filed: March 13, 2008
    Publication date: September 18, 2008
    Applicant: GAMBRO BCT, INC.
    Inventor: Glen Delbert ANTWILER
  • Publication number: 20080220523
    Abstract: Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. Detachable flow circuits and methods of expanding cells are also provided.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 11, 2008
    Applicant: Gambro BCT, Inc.
    Inventor: Glen Delbert Antwiler
  • Publication number: 20080220959
    Abstract: A bag loader for loading and unloading at least one satellite bag into and from the central compartment of a rotor of an apparatus for separating a composite liquid into at least two components comprises an upper part for removably securing an upper portion of at least one satellite bag; a lower part comprising a receptacle; and an intermediate part connecting the upper part to the lower part and exposing an intermediate portion of a satellite bag.
    Type: Application
    Filed: August 14, 2006
    Publication date: September 11, 2008
    Applicant: GAMBRO BCT, INC.
    Inventors: Brian M. Holmes, Johan-Petter Hagstrom, Charles L. Hake
  • Publication number: 20080220522
    Abstract: This invention is directed toward methods of moving cells throughout a hollow fiber bioreactor using fluid flow.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 11, 2008
    Applicant: GAMBRO BCT, INC.
    Inventor: Glen Delbert Antwiler
  • Publication number: 20080213894
    Abstract: A disposable apparatus for cell expansion, having at least one bioreactor. The bioreactor has a cellular growth area and a supply area, the cellular growth area being separated from said supply area by a membrane. A fluid recirculation path in fluid communication with the cellular growth area allows for hermetically removing a sample containing cellular matter. This may comprise an elongated tube, or a plurality of parallel tube segments. The parallel tube segments have inflow ends and outflow ends, and the inflow ends are joined at a first common juncture and the outflow ends are joined at a second common juncture. The common junctures may comprise valves.
    Type: Application
    Filed: January 28, 2008
    Publication date: September 4, 2008
    Applicant: GAMBRO BCT, INC.
    Inventor: Glen Delbert Antwiler
  • Patent number: 7413665
    Abstract: A system for separating a composite fluid into component parts thereof, including: a centrifuge having a rotor with a separation space and at least two valve members disposed thereon and a container set having a separation container adapted to be disposed in the separation space of the rotor and first and second collection containers connected to the separation container by a first and a second tubes. The tubes are adapted to be disposed in operative relationship with the valve members so that flow through the tubes may be controlled thereby. Three components of the composite fluid may be separated therefrom by the present system and two components may be moved to the collection containers. The container set may further include a third collection container connected to the separation container by a tube, and a third component may thus be moved to this third container.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: August 19, 2008
    Assignee: Gambro BCT, Inc.
    Inventors: Brian M. Holmes, Johan-Petter Hagström, Per-Olov Lundberg, Geert Van Waeg, Peter Nordgren
  • Publication number: 20080149564
    Abstract: Method and apparatus for separating a volume of whole blood into at least a plasma component and a red blood cell component comprising centrifuging a separation bag containing a volume of whole blood so as to separate therein at least a first component comprising plasma and a second component comprising red blood cells; transferring the first component into a plasma component bag during centrifugation of the separation bag; transferring into the separation bag a volume of wash solution from a wash solution bag during centrifugation of the separation bag; mixing the volume of wash solution with the second component; centrifuging the separation bag so as to separate therein a washed red blood cell component and a supernatant component; and transferring the supernatant component into a waste bag during centrifugation of the separation bag.
    Type: Application
    Filed: December 5, 2007
    Publication date: June 26, 2008
    Applicant: GAMBRO BCT, INC.
    Inventor: Brian M. HOLMES
  • Publication number: 20080147240
    Abstract: An apparatus and a method for separating at least two discrete volumes of a composite liquid into at least two components. Independent microprocessors are provided on a rotor of a centrifugal separation apparatus, which respond to commands from a control computer, gather sensor data and independently control devices on the rotor to process one or more volumes of a composite liquid such as blood. Multiple microprocessors communicate with the control computer across a single communication channel, such as a pair of slip rings or an infrared communications link.
    Type: Application
    Filed: February 26, 2007
    Publication date: June 19, 2008
    Applicant: GAMBRO BCT INC.
    Inventors: Darryl Hudock, Peter FLETCHER-HAYNES, Wilfred Ivan TUCKER, Daniel A. JOSEPH, Steven INGEBRIGTSEN, John Sample
  • Publication number: 20080132876
    Abstract: This invention is directed toward a connector system for the fluid connection of sterile systems comprising a male luer connecting element and a female luer connecting element. Both the male and female luer connecting elements have openable ends aseptically sealed closed by piercable membranes.
    Type: Application
    Filed: August 8, 2007
    Publication date: June 5, 2008
    Applicant: GAMBRO BCT, INC.
    Inventor: Thomas J. FELT
  • Publication number: 20080093312
    Abstract: A method for separating a volume of a composite liquid into at least a first component and a second component is performed in a centrifuge cooperating with a separation bag containing the volume of composite liquid. The separation bag is connected to at least a first component bag and a second component bag. The separation bag is spun so as to centrifuge the volume of composite liquid and cause the sedimentation of the at least first and second components. When the at least first and second components have sedimented, the first component is transferred at least one first transfer flow rate into the first component bag. When the first component has been transferred into the first component bag, the second component is transferred into the intermediate component bag at least one second transfer flow rate that is different from the at least one first transfer flow rate.
    Type: Application
    Filed: December 14, 2007
    Publication date: April 24, 2008
    Applicant: GAMBRO BCT, INC.
    Inventors: Brian HOLMES, Peter PIHLSTEDT, Geert VAN WAEG
  • Publication number: 20080087613
    Abstract: A method for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising centrifuging at least two separation bags containing two discrete volumes of a composite liquid respectively, so as to separate therein the first and second components; transferring at least one fraction of a first separated component from the separation bags into satellite bags connected thereto respectively; detecting a characteristic of a component at determined location in each separation bag; and stopping transferring the at least one fraction of the first component from each separation bag into the first satellite bag connected thereto, upon detection of the characteristic of a component at the determined location.
    Type: Application
    Filed: December 12, 2007
    Publication date: April 17, 2008
    Applicant: GAMBRO BCT, INC.
    Inventors: Darryl HUDOCK, Daniel JOSEPH, Victor DOLECEK
  • Publication number: 20080090714
    Abstract: An apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component comprises a centrifuge, which comprising a rotor having a rotation axis, comprising at least two separation cells, each for containing a separation bag containing a volume of composite liquid; and a first balancing means for balancing the rotor when the respective weights of the at least two separation bags in the at least two separation cells are different.
    Type: Application
    Filed: December 12, 2007
    Publication date: April 17, 2008
    Applicant: Gambro BCT, Inc.
    Inventors: Darryl HUDOCK, Daniel JOSEPH, Victor DOLECEK