Abstract: An extracorporeal blood treatment apparatus comprises a blood treatment device (2), an extracorporeal blood circuit, a blood pump (8) configured to be coupled to a blood withdrawal line (6) of the extracorporeal blood circuit. A closed fluid line (10) is connected to an inlet port (4a) and to an outlet port (4b) of a fluid chamber (4) of the blood treatment device (2), wherein the closed fluid line (10) together with the fluid chamber (4) forms a recirculation loop. An evacuation line (15) departs from the closed fluid line (10). A warming device (13) and a recirculation pump (17) are coupled or configured to be coupled to the closed fluid line (10). At least one temperature sensor (22) is operative on the extracorporeal blood circuit and it is configured to sense a blood temperature (Tb).

Abstract: Non-invasive heartbeat sensor for determining a heart rate in a conduit of an extracorporeal blood treatment apparatus, comprising one source for directing an optical signal towards the blood flowing in the segment; one detector for receiving an optical informative signal comprising the signal emitted by said source after passing the blood, and emitting respective output signal; a controller receiving the respective output signal and retrieving a heartbeat frequency and a heart rate value, based on the output signal, wherein the informative signal is altered by flow perturbation of the blood partially generated by the flow impulses originated by the heart.

Abstract: An extracorporeal circulation blood or treatment device (100) comprising an arterial pressure sensor (112) and a blood pump (111) is set up to determine amplitude variation and frequency of the pressure signals received from said arterial pressure sensor (112), calculate a parameter value based on said amplitude variation and said frequency, and issue an alarm if the parameter value exceeds a pre-set threshold value. Such detection aims at monitoring the occurrence of oscillating pressure signals. Such signals indicate an increased risk for hemolysis.

Abstract: An apparatus (1a) for extracorporeal blood treatment, comprising an infusion control arrangement (8) arranged for infusing a pre-dilution flow rate upstream a blood treatment unit (4) and a post-dilution flow rate downstream the blood treatment unit (4), an ultrafiltration, UF, arrangement (40) arranged for ultrafiltration of a liquid through a semipermeable membrane (7) of the blood treatment unit (4) and a control unit (31). The control unit (31) is configured to configure the infusion control arrangement (8) to obtain a plurality of different configurations of the pre-dilution flow rate and/or post-dilution flow rate.

Abstract: The present disclosure relates to a diffusion device, such as a blood oxygenator or gas exchanger, having improved flow characteristics.

Abstract: An apparatus for extracorporeal treatment of blood comprising a filtration unit, a blood withdrawal line, a blood return line, an effluent fluid line, a pre and/or post-dilution fluid line connected to the blood withdrawal line, and a dialysis fluid line. Pumps act on the fluid lines for regulating the flow of fluid. A control unit is configured to set initial values to one or more fluid flow rates through the above lines and to periodically execute a flow rate update procedure in order to deliver a set dose (Dset) in a reference time interval.

Abstract: A container for warming fluids comprises an inlet port, an outlet port, a fluid conduit configured for fluidly communicating the inlet and outlet ports, and deflection sections. The fluid conduit has a non-constant maximum width in a direction of fluid flow through the fluid conduit. The deflection sections further comprise an entry section and an exit section, each respective exit section being arranged downstream, in the direction of fluid flow, from each respective entry section. The maximum width of the fluid conduit decreases along the direction of fluid flow through the entry section over a first distance and the maximum width of the fluid conduit increases along the direction of fluid flow through the exit section over a second, different distance. A blood treatment apparatus including the above-described container is also provided.

Abstract: A method and apparatus for evaluating a condition of a water purification system (40, 110) comprising a water purification apparatus (110) arranged to output purified water through an outlet (128) and through at least one sterilizing grade filter (70a, 70b) of a line set (40) fluidly connected to the outlet (128), the method comprises: monitoring a flow rate (S1) correlated with the flow rate of the purified water flowing through the at least one sterilizing grade filter (70a, 70b); monitoring a pressure (S2) correlated with the pressure of the purified water flowing to the at least one sterilizing grade filter (70a, 70b); and evaluating (S3) a condition of the water purification system based on a relationship between the monitored flow rate and the monitored pressure.

Abstract: The present disclosure relates to a process and an apparatus for potting hollow fiber membranes in a diffusion and/or filtration device, e.g., an ultrafilter or a capillary dialyzer.

Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit connected to a blood circuit and to a dialysate circuit, a preparation device for preparing and regulating the composition of the dialysis fluid; a control unit is configured for receiving a desired sodium mass transport at the end of the treatment session and for setting the sodium concentration value for the dialysis fluid in the dialysis supply line at a set point to achieve the desired sodium mass transport at the end of the treatment session.

Abstract: Systems and methods for renal insufficiency treatment that include identifying and associating a solution container with a container support in the systems and methods are described herein. The systems and methods may associate an identified solution with an identified container support and verify compatibility of that combination with a selected treatment to reduce the likelihood for errors during setup and use of the systems and methods.

Abstract: The present invention relates to a continuous process for preparing permselective hollow fiber membranes being suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood which comprises a two-stage drying and tempering treatment of the hollow fiber membranes. According to a further aspect, the invention relates to a continuous process for drying permselective hollow fiber membranes on-line. The invention also relates to devices for on-line drying of permselective hollow fiber membranes.

Abstract: A fluid warming device for an extracorporeal blood treatment apparatus, comprises: an outlet temperature sensor (31) operatively active at an outlet (22) of a fluid warming path (23) to detect a measured outlet temperature (To) of a fluid leaving the fluid warming device (18); an electronic control unit (29) operatively connected to the outlet temperature sensor (31). The electronic control unit (29) is configured to perform the following procedure: receiving, from the outlet temperature sensor (31) a signal correlated to a measured outlet temperature (To); correcting the measured outlet temperature (To) through a correction model to obtain an actual fluid outlet temperature (Tout); adjusting a heating power (Ph) of heating elements to keep the actual fluid outlet temperature (Tout) at a set reference temperature value (Tset).

Abstract: An apparatus for extracorporeal treatment of blood (1) comprising a filtration unit (2), a blood withdrawal line (6), a blood return line (7), an effluent fluid line (13), a pre and/or post-dilution fluid line (15, 25) connected to the blood withdrawal line, and a dialysis fluid line. Pumps (17, 18, 21, 22, 27) act on the fluid lines for regulating the flow of fluid. A control unit (10) is configured to periodically calculate a new value for the patient fluid removal rate to be imposed on an ultrafiltration actuator in order to keep a predefined patient fluid removal rate across a reference time interval irrespective of machine down times.

Abstract: The present disclosure relates to a process and a device for winding a strand of hollow fiber membranes.

Abstract: The present disclosure relates to methods for authorizing user access to medical equipment via an equipment user interface. In an example, the method comprises, storing an authority public key of an authority asymmetric key pair and providing, to a user via an equipment user interface, an authorization challenge indicative of an equipment public key of a temporary equipment asymmetric key pair generated in medical equipment. The method further comprises receiving from the equipment user interface, a response code comprising validity information encrypted using a shared key derivable from the authority private key of the authority asymmetric key pair and the provided equipment public key, and authorizing the user access to the medical equipment, upon the validity information decrypted using the same shared key but derived in the medical equipment using the stored authority public key and an equipment private key of the temporary equipment asymmetric key pair, being valid.

Abstract: A patient fluid removal compensation volume may be determined to make up for the patient fluid removal that does not occur during machine down times, and the patient fluid removal rate may be increased until the compensating volume is satisfied.

Abstract: The present invention relates to removal of protein bound deleterious substances from an extracorporeal biological fluid by changing the affinity of the substance to the protein. The invention relates to the use of displacer substances for removal of deleterious substances. The present invention also relate to a method of removal, a system, a cleaning fluid comprising the displacer substances for removal of deleterious substances.

Abstract: The invention relates to a blood treatment device configured to dephosphorylate extracellular adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and/or lipopolysaccharide (LPS) in the blood of a patient in need thereof in an extracorporeal blood circuit, wherein the device comprises a matrix having alkaline phosphatase (AP) immobilized thereon. The invention further relates to an extracorporeal blood circuit comprising a blood treatment device of the invention and to the blood treatment device for use as a medicament or to methods of treating an infection, preferably a blood or systemic infection, such as sepsis, and/or for the treatment of sepsis-associated acute kidney injury (AKI).

Abstract: A connector arrangement (10) for connecting to a fluid chamber (6) of a blood treatment unit (4) for extracorporeal blood treatments. The connector arrangement (10) includes a connector device (11) with a connector body (47) comprising a port opening (43) and an interior wall (50) defining a port space (39) designed to receive a first fluid port (8A) of the fluid chamber (6). The connector device (11) also incorporates a fluid path (35a) extending from the port space (39) to a first end opening (51) of the connector device (11), and an air path (36a) extending from the port space (39) to a second end opening (52) of the connector device (11), wherein the fluid path (35a) and the air path (36a) are separate paths. Also a system (1) for extracorporeal blood treatment including the connector arrangement (10) and a method for priming the fluid chamber (6).