Patents Assigned to Ganmab A/S
  • Antibodies capable of binding to OX40, variants thereof and uses thereof
    Patent number: 12410258
    Abstract: The present invention relates to antibodies capable of binding to human OX40 and to variants thereof comprising a modified Fc region comprising at least one mutation that enhances the Fc-Fc interaction of the antibody and at least one mutation that reduces the Fc effector functions of the antibody. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
    Type: Grant
    Filed: May 10, 2024
    Date of Patent: September 9, 2025
    Assignees: Ganmab A/S, BioNTech SE
    Inventors: Kristel Kemper, Maarten van der Kroef, Dennis Verzijl, Andrea Gorlani, Pauline Linda de Goeje, Lars Guelen, David Satijn, Esther C. W. Breij, Ugur Sahin, Sina Fellermeier-Kopf, Maren Köhne