Patents Assigned to Gattefosse, S.A.
  • Orally administrable composition capable of providing enhanced bioavailability when ingested
    Patent number: 6312704
    Abstract: Composition for pharmaceutical or cosmetic use, capable of providing enhanced bioavailability when ingested, comprising at least a pharmaceutical active ingredient, a lipophilic phase consisting of a mixture of fatty acid esters and glycerides, a surfactant (SA), and a cosurfactant (CoSA). The lipophilic phase consists of a mixture of C8 to C18 polyglycolized glycerides having hydrophilic-lipophilic balance (HLB) of less than 16, this lipophilic phase representing from 32 to 75% of the total weight of the composition. The surfactant (SA) is chosen from the group comprising saturated C8-C10 polyglycolized glycerides and oleic esters of polyglycerol, this surfactant having an HLB of less than 16. The cosurfactant (CoSA) is chosen from the group comprising lauric esters of propylene glycol, oleic esters of polyglycerol and ethyl diglycol. The SA/CoSA ratio is between 0.5 and 6 and the hydrophilic phase of the final microemulsion is supplied after ingestion by the physiological fluid of the digestive milieu.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: November 6, 2001
    Assignee: Gattefosse, S.A.
    Inventors: Nabil Farah, Joel Denis
  • Process for stabilizing vegetable plants
    Patent number: 6270773
    Abstract: A process for preserving desired characteristics of vegetable plants for cosmetic, condimental, aromatic or food use is described which includes rehydrating harvested vegetable to nearly the water content of freshly harvested plants and then exposing them to microwave radiation to rapidly heat them to the denaturation temperature of the specific enzyme contained in the harvested plants.
    Type: Grant
    Filed: July 7, 1994
    Date of Patent: August 7, 2001
    Assignee: Gattefosse, S.A.
    Inventors: Aimée Gaillard Pourrat, Henri Pourrat
  • Method for preparing a pharmaceutical composition with modified release of the active principle, comprising a matrix
    Patent number: 6194005
    Abstract: The invention concerns a method for preparing a modified release of active principle. The method comprises the steps of mixing a powder composed of active principle, adjuvant or combinations thereof while heating and fluidizing in order to obtain individual grains, liquefying a lipid matrix agent composed of partial esters of alcohol with at least one fatty acid, coating the powder by spraying from 1 to 15% by weight of the final composition liquid lipid matrix agent over the individual grains, the spraying air pressure, and optionally the spraying rate varying throughout the coating operation and lowering the temperature of the combined product to allow the lipid matrix agent to solidify around the grains.
    Type: Grant
    Filed: March 23, 1999
    Date of Patent: February 27, 2001
    Assignee: Gattefosse, S.A.
    Inventors: Nabil Farah, Philippe Barthelemy, Joseph Joachim