Patents Assigned to GE Healthcare AS
  • Extraction separation using magnetic beads
    Patent number: 10040073
    Abstract: A method for purifying a substance in a solution in a simple streamlined process using a magnetic porous particle. For easy small scale purification of a substance, the magnetic porous particle is coated with either a hydrophilic or hydrophobic liquid and transferred into a second liquid containing the substance under conditions which allow said substance to partition into the first liquid within said magnetic porous particle. Finally the magnetic porous particle is removed from said second liquid, wherein the first and second liquid are substantially immiscible and the partition coefficient P of the substance between the first and second liquid is greater than 1.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: August 7, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Nils Norrman, Pierre Le Greves
  • Plastic Containers
    Publication number: 20180207297
    Abstract: The present invention provides a method for the commercial presentation of a solution of gadolinium-DOTA that provides certain advantages over the known methods.
    Type: Application
    Filed: January 22, 2018
    Publication date: July 26, 2018
    Applicant: GE HEALTHCARE AS
    Inventors: Karina Martha Langseth-Manrique, Arne Wang Aabye, Harald Laugen, Eva Krog Tamnes, Borge Mathisen
  • Method of operating an automated radiopharmaceutical synthesizer
    Patent number: 10029228
    Abstract: The present invention relates to calibration and normalization systems and methods for ensuring the quality of radiopharmaceuticals during the synthesis thereof, such as radiopharmaceuticals used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: July 24, 2018
    Assignee: GE Healthcare Limited
    Inventors: Torgrim Engell, Julian Grigg, Ingvil Gausemel, Knut Dyrstad, Jonathan R. Shales
  • Preparation of 18F-fluciclovine
    Patent number: 10023525
    Abstract: The present invention provides a method for the production of [18F]-FACBC which has advantages over know such methods. Also provided by the present invention is a system to carry out the method of the invention and a cassette suitable for carrying out the method of the invention on an automated radiosynthesis apparatus.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: July 17, 2018
    Assignee: GE Healthcare Limited
    Inventors: Anders Svadberg, Olav Ryan, Roger Smeets
  • System for synchronization in a line scanning imaging microscope
    Patent number: 10027855
    Abstract: A line confocal microscope system, comprising a scanning unit in the form of a mechanically driven scanning unit with a controllable a scanning trajectory and a two dimensional sensor unit operated in a rolling line shutter mode in synchronization with the scanning unit, wherein the scanning trajectory is set to have an acceleration part outside the field of view of the sensor unit.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: July 17, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCE CORP.
    Inventors: Witold Bula, Pavel A. Fomitchov, Steve Goodson, Erwen Mei, Yang Zhang
  • Temperature sensor means and a bioreactor system comprising a temperature sensor means
    Patent number: 10023833
    Abstract: A temperature sensor means comprising a thermally conducting layer arranged to face the surface to be measured, a thermally insulating layer attached to the thermally conducting layer on the opposite side to the surface to be measured, a temperature sensor provided between the thermally conducting layer and the thermally insulating layer and being completely surrounded on all its sides by either the thermally conducting or the thermally insulating layers.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: July 17, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Patrik Akerstrom, Hakan Wahlnas
  • Beta Amyloid Staging
    Publication number: 20180193490
    Abstract: The present invention relates to a method of in vivo imaging and in particular to a method for the evaluation of in vivo images of beta amyloid (A?) distribution in the brain of a subject suspected of having Alzheimer's disease (AD). The method of the present invention provides more detailed information to the clinician as compared with prior art methods, facilitating identification of those subjects who will benefit most from disease modifying therapies.
    Type: Application
    Filed: July 7, 2016
    Publication date: July 12, 2018
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Christopher John Buckley, Adrian Smith
  • Alternative process for the purification of an intermediate in the synthesis of non-ionic X-ray contrast agents
    Patent number: 10011560
    Abstract: Alternative continuous downstream processes for the production of 5-acetamido-N,N?-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”) are described. Compound A is a key intermediate in the production of iodixanol and iohexol, which are two of the biggest commercially available non-ionic x-ray contrast media agents.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: July 3, 2018
    Assignee: GE HEALTHCARE AS
    Inventors: Torfinn Haaland, Arne Askildsen, Rita Heskestad Kalleberg, Sumihar Silalahi, Alf Martin Farbrot, Inger Dagny Saanum
  • Method for cell culture
    Patent number: 10011816
    Abstract: A method for stem or progenitor cell culture. More precisely, the invention relates to a method for cell culture using one or more I?I (inter-alpha trypsin inhibitor or inter-alpha inhibitor) protein(s) or part(s) thereof as a component in a cell culture media or a coating on a cell culture surface material. Furthermore the invention relates to a cell culture media and a cell culture coating/matrix provided with one or more I?I proteins(s) or part(s) thereof.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: July 3, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Sara Pijuan Galito, Christoffer Tamm, Cecilia Anneren
  • Large volume disposable ultrafiltration systems and methods
    Patent number: 10010831
    Abstract: A disposable filtration system can include a disposable filter housing having an ultrafiltration filter contained therein. The disposable filtration system can further include a feed inlet and retentate outlet in fluid communication on one side of the filter and a permeate conduit on the other side of the filter for withdrawing permeate that passes through the filter. The system can include at least one disposable pressure control valve in fluid communication with either the retentate outlet or the permeate conduit and configured to regulate the pressure within the housing.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: July 3, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Scott A. Mangiacotti, Parrish M. Galliher, Joseph J. Arduino, Michael Fisher, John J. Vicalvi, Jr., Joseph Makowiecki
  • Radiolabelling Process
    Publication number: 20180177900
    Abstract: The present invention relates to a novel composition comprising 1-amino-3-[18F]-fluorocyclobutanecarboxylic acid ([18F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [18F]-FACBC. Also provided by the invention is a method to obtain said composition.
    Type: Application
    Filed: February 20, 2018
    Publication date: June 28, 2018
    Applicant: GE HEALTHCARE LIMITED
    Inventor: Torild Wickstrom
  • X-ray imaging contrast media with low iodine concentration and X-ray imaging process
    Patent number: 10004816
    Abstract: The present invention relates to X-ray examinations and to the improvement of patient safety during such. More specifically the invention relates to X-ray diagnostic compositions having low concentrations of iodine and an optimized amount of electrolytes. The invention further relates to methods of X-ray examinations wherein a body is administered with an X-ray diagnostic composition comprising a low concentration of iodine and irradiated with a radiation dose.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: June 26, 2018
    Assignee: GE HEALTHCARE AS
    Inventors: Ben Newton, Mikkel Thaning, Dirk-Jan in't Veld, Karina Langseth, Paul Michael Evans
  • Stabilisation of radiopharmaceutical precursors
    Patent number: 10000518
    Abstract: The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-ß-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: June 19, 2018
    Assignees: GE HEALTHCARE LIMITED, GE HEALTHCARE AS
    Inventors: Lill Torild Wickstrom, Dirk-Jan in't Veld, Nigel John Osborn, Julian Grigg, Anthony Wilson
  • Radiolabelling process
    Patent number: 9999692
    Abstract: The present invention relates to a novel composition comprising 1-amino-3-[18F]-fluorocyclobutanecarboxylic acid ([18F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [18F]-FACBC. Also provided by the invention is a method to obtain said composition.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: June 19, 2018
    Assignee: GE Healthcare Limited
    Inventor: Torild Wickstrom
  • Temperature sensor means and a bioreactor system comprising a temperature sensor means
    Patent number: 9994807
    Abstract: A temperature sensor means comprising a thermally conducting layer arranged to face the surface to be measured, a thermally insulating layer attached to the thermally conducting layer on the opposite side to the surface to be measured, a temperature sensor provided between the thermally conducting layer and the thermally insulating layer and being completely surrounded on all its sides by either the thermally conducting or the thermally insulating layers.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: June 12, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Patrik Akerstrom, Hakan Wahlnas
  • CHROMATOGRAPHY LIGAND
    Publication number: 20180154281
    Abstract: The present invention relates to a chromatography ligand defined by the following formula R1—R2—N(R3)—R4—R5 wherein R1 is a substituted or non-substituted phenyl group; R2 is a hydrocarbon chain comprising 0-4 carbon atoms; R3 is a hydrocarbon chain comprising 1-3 carbon atoms; R4 is a hydrocarbon chain comprising 1-5 carbon atoms; and R5 is OH or H. The invention also comprises a separation matrix, comprising the described ligands coupled to a porous support, such as particles or a membrane. The ligand and matrix according to the invention is useful for purification of biomolecules or organic compounds, such as proteins, polypeptides, DNA etc. An advantageous use according to the invention is the purification of antibodies.
    Type: Application
    Filed: January 29, 2018
    Publication date: June 7, 2018
    Applicant: GE Healthcare BioProcess R&D AB
    Inventors: CARINA ENGSTRAND, ANNIKA FORSS, GUNNAR GLAD, BO-LENNART JOHANSSON, HANS J JOHANSSON, JEAN-LUC MALOISEL
  • System and Method for User Intuitive Visual Management of Automation of Bioprocess
    Publication number: 20180157229
    Abstract: A system for providing an improved way of user intuitive visual management of bioprocess automation is disclosed. The system includes a processor and a memory. The processor is configured to present a graphical presentation of the bioprocess automation script and results associated with execution of the bioprocess automation script of a bioprocess, wherein the graphical presentation comprises an anticipated result and an anticipated flow path associated with the bioprocess; and modify the graphical presentation by varying at least one of the anticipated result and the anticipated flow path.
    Type: Application
    Filed: April 21, 2016
    Publication date: June 7, 2018
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Dalesh Dharamshi, Sudheer Mygapula
  • Radiotracer compositions
    Patent number: 9987382
    Abstract: The present invention relates to improved radiotracer imaging agent compositions, which comprises 18F-labelled biological targeting moieties, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions, together with radiofluorinated aldehyde compositions useful in preparing said radiotracer compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: June 5, 2018
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas
  • Display screen with a graphical user interface
    Patent number: D822708
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: July 10, 2018
    Assignee: GE Healthcare UK Limited
    Inventor: Pratik Ghosh
  • Biological sample collector device
    Patent number: D824531
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: July 31, 2018
    Assignee: GE Healthcare UK Limited
    Inventors: Cheryl Louise Potts, Neil Williams, Christopher Burrows