Patents Assigned to GE Healthcare AS
  • System for preparing an image for segmentation
    Patent number: 9275465
    Abstract: A system for cleaning up and preparing an image for segmentation is disclosed. An image transmitting device is configured to transmit a first image to an image receiving device. The image receiving device is configured to: receive the first image; apply a Dual Tree Complex Wavelet transform to the first image to form a plurality of sub-images; generate a high pass image based on the plurality of sub-images; generate a rotational invariant resultant image based on the high pass image; generate a low pass image based on the plurality of sub-images; and combine the rotational invariant resultant image and the low pass image to form a pseudo-fluorescent image.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: March 1, 2016
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventor: Joseph J. O Ruanaidh
  • METHOD FOR CELL CULTURE
    Publication number: 20160053225
    Abstract: A method for stem or progenitor cell culture. More precisely, the invention relates to a method for cell culture using one or more I?I (inter-alpha trypsin inhibitor or Inter-alpha inhibitor) protein(s) or part(s) thereof as a component in a cell culture media or a coating on a cell culture surface material. Furthermore the invention relates to a cell culture media and a cell culture coating/matrix provided with one or more I?I proteins(s) or part(s) thereof.
    Type: Application
    Filed: March 27, 2014
    Publication date: February 25, 2016
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Sara Pijuan Galito, Christoffer Tamm, Cecilia Anneren
  • Radiolabelling Process
    Publication number: 20160051710
    Abstract: The present invention relates to a novel composition comprising 1-amino-3[18F]-fluorocyclobutanecarboxylic acid ([18F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [18F]-FACBC. Also provided by the invention is a method to obtain said composition.
    Type: Application
    Filed: March 28, 2014
    Publication date: February 25, 2016
    Applicant: GE Healthcare Limited
    Inventor: Torild Wickstrom
  • Chromatography ligand
    Patent number: 9266041
    Abstract: The present invention relates to a chromatography ligand defined by the following formula R1—R2—N(R3)—R4—R5 wherein R1 is a substituted or non-substituted phenyl group; R2 is a hydrocarbon chain comprising 0-4 carbon atoms; R3 is a hydrocarbon chain comprising 1-3 carbon atoms; R4 is a hydrocarbon chain comprising 1-5 carbon atoms; and R5 is OH or H. The invention also comprises a separation matrix, comprising the described ligands coupled to a porous support, such as particles or a membrane. The ligand and matrix according to the invention is useful for purification of biomolecules or organic compounds, such as proteins, polypeptides, DNA etc. An advantageous use according to the invention is the purification of antibodies.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: February 23, 2016
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Bo-Lennart Johansson, Jean-Luc Maloisel, Hans J. Johansson, Asa Ek, Maria Holm, Jafar Saidzadeh
  • Technetium labelled peptides
    Patent number: 9259496
    Abstract: The present invention relates to technetium imaging agents comprising radiolabeled c-Met binding peptides suitable for SPECT or PET imaging in vivo. The c-Met binding peptides are labelled via chelator conjugates. Also disclosed are pharmaceutical compositions, methods of preparation of the agents and compositions, plus methods of in vivo imaging using the compositions, especially for use in the diagnosis of cancer.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: February 16, 2016
    Assignee: GE Healthcare Limited
    Inventors: Peter Brian Iveson, Bard Indrevoll, Ben Newton, Rajiv Bhalla, Edvin Wilhelm Johannesen
  • Solid matrix for one step nucleic acid amplification
    Patent number: 9260711
    Abstract: The present invention to relates to methods and kits which can be used to amplify nucleic acids with the advantage of decreasing user time and possible contamination. The PCR reagents are bound to a solid matrix for easy processing and amplification of DNA samples.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: February 16, 2016
    Assignee: GE HEALTHCARE UK LIMITED
    Inventors: Kathryn L. Lamerton, Cheryl L. Potts, Simon L. Stubbs, Michael K. Kenrick
  • Method for production of chromatography media
    Patent number: 9259729
    Abstract: The present invention relates to a method and means to produce chromatography media having improved pressure-flow properties. More closely, the invention relates to bimodal particle size distribution and the use of layer functionalization as means to change pressure-flow properties of chromatography media. The invention relates to a method for production of chromatography media having improved pressure-flow properties, comprising mixing large beads/particles, comprising an inner core and an outer functionalized shell/lid, with smaller beads/particles, wherein the ratio of the particle size of large and small beads: [D50V for large particles/D50V for small particles]>1.2, and wherein the volume ratio of large and small beads in the column: [Total volume of large beads/Total volume beads] is in the range 0.05-0.9.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: February 16, 2016
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Jan Bergstrom, Bo-Lennart Johansson
  • Hyperpolarized lactate contrast agent for determination of LDH activity
    Patent number: 9259490
    Abstract: A hyperpolarized MR imaging medium and a method of 13C-MR detection using a hyperpolarized MR imaging medium for the determination of lactate dehydrogenase (LDH) activity. The contrast media comprises hyperpolarized [13C, 2H]lactate.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: February 16, 2016
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Kevin Brindle, Mikko Iivari Kettunen, Brett W.C. Kennedy
  • Laser beam irradiance control systems
    Patent number: 9256066
    Abstract: Irradiance control systems (“ICSs”) that control the irradiance of a beam of light are disclosed. ICSs include in a beam translator and a beam launch. The beam translator translates the beam substantially perpendicular to the propagating direction of the beam with a desired displacement so that the beam launch can remove a portion of the translated beam and the beam can be output with a desired irradiance. The beam launch attenuates the irradiance of the beam based on the amount by which the beam is translated. ISCs can be incorporated into fluorescent microscopy instruments to provide high-speed, fine-tune control over the irradiance of excitation beams.
    Type: Grant
    Filed: January 16, 2012
    Date of Patent: February 9, 2016
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Jeremy R. Cooper, Steven A. Reese, William M. Dougherty
  • Vaccine stabilizer
    Patent number: 9248107
    Abstract: Disclosed herein is a formulation capable of enhancing thermostability and shelf-life of a biological product, the formulation comprising: a tertiary amine N-oxide or a derivative thereof represented by the formulae: wherein R1, R2, and R3 may be identical or different and each is a straight or branched lower alkyl group having from 1 to 4 carbon atoms; an inorganic salt; glutamic acid or a salt thereof; a polyol; a physiologically acceptable buffer, and a pharmaceutically acceptable carrier. The tertiary amine N-oxide may be trimethylamine-N-oxide, (CH3)3NO. The formulation is useful for vaccine stabilization.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: February 2, 2016
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Tianxiao Sun, Philip M. Levesque, Alicja T. Brown, Cynthia K. Lee
  • Radiotracer Compositions
    Publication number: 20160022847
    Abstract: The present invention relates to improved radiotracer imaging agent compositions, which comprises 18F-labelled biological targeting moieties, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions, together with radiofluorinated aldehyde compositions useful in preparing said radiotracer compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.
    Type: Application
    Filed: October 7, 2015
    Publication date: January 28, 2016
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas
  • SYNTHON COMPOSITION
    Publication number: 20160022845
    Abstract: The present invention relates to an improved [18F]labelled synthon composition, wherein the non-radioactive impurities in said composition have been found to be more straightforward to remove than with known compositions comprising said [18F]labelled synthon. The resultant purified [18F]label led synthon therefore can be used in the production of a positron emission tomography (PET) tracer having improved properties for in vivo imaging. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.
    Type: Application
    Filed: March 28, 2013
    Publication date: January 28, 2016
    Applicant: GE HEALTHCARE LIMITED
    Inventors: RAJIV BHALLA, ALEXANDER JACKSON, GARETH SMITH
  • Preparation of a 1-amino-3-hydroxy-cyclobutane-1-carboxylic acid derivative
    Patent number: 9242924
    Abstract: The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor of the [18F]-1-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET agent, ensuring that the reaction efficiently goes to completion.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: January 26, 2016
    Assignee: GE Healthcare Limited
    Inventors: Steven Michael Fairway, Marit Rolandsgard
  • Process simplification for precursor compound
    Patent number: 9238596
    Abstract: The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor useful in the preparation of the [18F]-1-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET tracer.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: January 19, 2016
    Assignee: GE Healthcare Limited
    Inventor: Tom Christian Berg
  • ULTRASOUND IMAGE DISPLAYING APPARATUS AND METHOD FOR DISPLAYING ULTRASOUND IMAGE
    Publication number: 20150379700
    Abstract: An ultrasound image displaying apparatus includes: a composite data generating unit which generates composite data in which data based on echo signals obtained by transmitting ultrasound to a subject are multiple-frame combined; a display unit on which an ultrasound image based on the composite data is displayed; and an index calculating unit which calculates an index related to the amount of motion artifacts in the ultrasound image for each frame, based on the data. The composite data generating unit generates composite data combined using data of some or all frames in each of which the index satisfies a prescribed reference.
    Type: Application
    Filed: February 12, 2014
    Publication date: December 31, 2015
    Applicant: GE Healthcare Japan Corporation
    Inventors: Naohisa KAMIYAMA, Hiroshi HASHIMOTO
  • Indole derivatives
    Patent number: 9220795
    Abstract: An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: December 29, 2015
    Assignee: GE Healthcare Limited
    Inventors: Harry John Wadsworth, Dennis O'Shea, Joanna Passmore, William Trigg, Amanda Eewan, Bo Shan
  • Simulator device
    Patent number: 9216388
    Abstract: A simulator device configured to replace a filtration unit in a crossflow filtration system comprises a feed inlet (41), a first flow path (43) connected to the feed inlet (41) for simulating a retentate flow in the filtration unit, and a second flow path (44) connected to the feed inlet (for simulating a permeate flow in the filtration unit. Adjustable valve means (45, 46) are provided for controlling at least one of the simulated retentate flow and the simulated permeate flow.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: December 22, 2015
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Robert Hogstedt, Jan-Erik Lynga, Perhenric Lonnberg, Mikael Sjogren, Johan Soderstrom
  • EXTRACTION SEPARATION USING MAGNETIC BEADS
    Publication number: 20150360232
    Abstract: A method for purifying a substance in a solution in a simple streamlined process using a magnetic porous particle. For easy small scale purification of a substance, the magnetic porous particle is coated with either a hydrophilic or hydrophobic liquid and transferred into a second liquid containing the substance under conditions which allow said substance to partition into the first liquid within said magnetic porous particle. Finally the magnetic porous particle is removed from said second liquid, wherein the first and second liquid are substantially immiscible and the partition coefficient P of the substance between the first and second liquid is greater than 1.
    Type: Application
    Filed: January 29, 2014
    Publication date: December 17, 2015
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Nils NORRMAN, Pierre LE GREVES
  • CHROMATOGRAPHY COLUMN AND METHOD OF CONDUCTING MAINTENANCE ON A CHROMATOGRAPHY COLUMN
    Publication number: 20150336027
    Abstract: A chromatography column including: a tubular housing; a first end unit removably connected to a first end of the tubular housing; a second end unit removably connected to a second end of the tubular housing; an adaptor assembly movable within said tubular housing; an adaptor rod connected to said adaptor assembly, which adaptor rod is arranged to extend through an opening in the first end unit; a filter removably connected to the adaptor assembly; and a frame connected to said tubular housing for supporting the column on a floor. At least an actuating means is arranged on the frame, so that the column can be lifted and lowered in a substantially vertical direction.
    Type: Application
    Filed: June 18, 2013
    Publication date: November 26, 2015
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Stefan Kjell ERIKSSON, Andreas BERGSTROM
  • Zinc Halide Mediated Cyclization Process Leading to Tricyclic Indoles
    Publication number: 20150336891
    Abstract: The present invention relates to a method for the production of tricyclic indole compounds comprising a cyclization step wherein this step is improved over known methods.
    Type: Application
    Filed: November 29, 2013
    Publication date: November 26, 2015
    Applicant: GE Healthcare Limited
    Inventors: Sondre Nilsen, Umamaheshwar P. Mokkapati