Patents Assigned to GE Healthcare AS
  • Gel for isoelectric focusing
    Patent number: 8858771
    Abstract: The present invention relates to the field of electrophoresis and more specifically to a gel or strip for separating peptide components by isoelectric focusing by producing IPG (immobilized pH gradient) gels or strips in a novel way before focusing. More closely, the peptides are focused in a novel IPG gel including an uneven or non-linear pH gradient having at least three separate stepwise arranged pH-intervals. After focusing the peptide resolution is high and the peptides are evenly distributed along the gel.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: October 14, 2014
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Bengt Bjellqvist, Kristina Uhlen
  • PACKAGE
    Publication number: 20140299568
    Abstract: The present invention relates to a package, and more particularly to a package for sterile fluids, such as contrast media. More particularly the invention relates to a package comprising a container, a connecting plug and a cap. The package hence includes an integrated connection for easily transferring the content of the container of the package, e.g. to a syringe, a tube or a cartridge.
    Type: Application
    Filed: December 14, 2012
    Publication date: October 9, 2014
    Applicant: GE HEALTHCARE AS
    Inventor: Martin Monteagle Browne
  • SAMPLE PRESERVATION METHOD AND SAMPLE PRESERVATION SUBSTRATE
    Publication number: 20140302521
    Abstract: The invention discloses a cellulose or glass fibre paper for preservation of biological samples, which comprises 4-30 wt % of a hydrophilic branched carbohydrate polymer. It also discloses a method for preservation of biological samples by applying and drying them on the paper.
    Type: Application
    Filed: October 29, 2012
    Publication date: October 9, 2014
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Mattias Algotsson, Miles W. Burrows, Jimmy Hedin Dahlstrom, Ylva Laurin, Ronnie Palmgren, Jinyu Zou
  • BIOLOGICAL SAMPLE COLLECTION DEVICE
    Publication number: 20140303518
    Abstract: Biological samples, such as saliva, are commonly collected on a swab and subsequently transferred to an absorbent storage medium. Embodiments of the present invention provide a biological sample collection device 600 comprising a collection portion 620 and a body portion 610, the body portion including a holding portion 652 for holding a biological sample storage medium (618 FIG. 1), and a sample collection/transfer means. The collection portion 620 can be arranged in a first position shown in FIG. 4, separated from the body portion for collecting a sample. The device employs depressible latches (630, 640 FIG. 6) to control the movements of the collection portion.
    Type: Application
    Filed: October 31, 2012
    Publication date: October 9, 2014
    Applicant: GE HEALTHCARE UK LIMITED
    Inventors: Alan Stuart Pierce, Simon Laurence John Stubbs, David Gwyn Treharne, Cheryl Louise Potts
  • PARTITIONED REACTION VESSELS
    Publication number: 20140303381
    Abstract: In view of the needs of the art, the present invention provides a reaction vessel having two distinct compartments, for separating solid-supported reagents. The present invention also provides a method to perform two step radiochemistry procedures in one reactor in a clean and 10 efficient manner. An example of the chemistry that could benefit from this approach is ‘click’ radiochemistry. The present invention provides a method to form the synthon, and react it with an alkyne without the need to perform a purification step.
    Type: Application
    Filed: October 1, 2012
    Publication date: October 9, 2014
    Applicant: GE HEALTHCARE LIMITED
    Inventor: Alexander Jackson
  • BIOLOGICAL SAMPLE STORAGE APPARATUS AND METHOD
    Publication number: 20140298926
    Abstract: Disclosed is a biological sample holder, a container for storing multiple holders, and an automated holder retrieval system. The sample holder may comprise an elongate generally planar support including a handle end and an opposing biological sample storage end, wherein, a substrate for accepting a biological sample is mounted to the holder at said sample storage end. Optionally the substrate is so mounted within a recess in the surface of the support and the recess has a local surface providing a reaction surface for allowing a sub-sample to be removed from the medium by mechanical action, such as cutting or punching. The container may include an array of wells each well being generally square or rectangular in plan and the holders dimensioned so that they are held diagonally in a respective well.
    Type: Application
    Filed: November 30, 2012
    Publication date: October 9, 2014
    Applicant: GE HEALTHCARE UK LIMITED
    Inventors: Michael Kenneth Kenrick, Geraint Seymour
  • Chelator conjugates
    Patent number: 8852550
    Abstract: The present invention relates to improved chelator conjugates with biological targeting molecules, suitable for forming metal complexes with radiometals. The radiometal complexes, especially with the radiometal 99mTc, are useful as radiopharmaceuticals.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: October 7, 2014
    Assignee: GE Healthcare Limited
    Inventors: Colin Mill Archer, Harry John Wadsworth, Torgrim Engell
  • Labelled biotin conjugates
    Patent number: 8846001
    Abstract: The present invention provides radioactive gallium complexes which comprise DOTA-biotin conjugates, incorporating a linker group. Also described are radiopharmaceutical compositions, and methods and uses of the complexes for in vivo imaging involving pre-targeting with avidin.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: September 30, 2014
    Assignees: GE Healthcare Limited, Hammersmith Imanet Limited
    Inventors: Irina Velikyan, Elisabeth Blom, Bengt Langstrom
  • Device and method for separation of proteins and other biomolecules
    Patent number: 8844385
    Abstract: The present invention relates to a device and method for separation of proteins and other biomolecules. A preferred use is for sample preparation of crude as well as pre-fractionated samples. In a preferred embodiment, the device of the present invention is a pipette tip having dual channels, one for inlet of sample and one for outlet. The outlet, but not the inlet, channel is provided with sample separation media for separation of a desired biomolecule from a sample. The flow through the sample separation media is unidirectional.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: September 30, 2014
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Nils Norrman, Ronnie Palmgren
  • ARYLOXYANILIDE IMAGING AGENTS
    Publication number: 20140288317
    Abstract: The present invention provides a novel radiolabelled aryloxyalinine derivative suitable for in vivo imaging. In comparison to known aryloxyalinine derivative in vivo imaging agents, the in vivo imaging agent of the present invention has better properties for in vivo imaging. The in vivo imaging agent of the present invention demonstrates good selective binding to the peripheral benzodiazepine receptor (PBR), in combination with good brain uptake and in vivo kinetics following administration to a subject.
    Type: Application
    Filed: June 4, 2014
    Publication date: September 25, 2014
    Applicant: GE HEALTHCARE LIMITED
    Inventors: HARRY JOHN WADSWORTH, DENNIS O'SHEA
  • IMAGING AGENTS WITH IMPROVED PHARMACOKINETIC PROFILES
    Publication number: 20140286866
    Abstract: The invention relates to compounds suitable for use in an imaging agent said imaging agent showing an improved pharmacokinetic profile.
    Type: Application
    Filed: June 4, 2014
    Publication date: September 25, 2014
    Applicant: GE HEALTHCARE AS
    Inventors: ALAN CUTHBERTSON, MAGNE SOLBAKKEN
  • CHROMATOGRAPHY COLUMN
    Publication number: 20140284260
    Abstract: A chromatography column having a longitudinal axis and comprising a column wall with a first end and a second end, a first end plate assembly removably connectable to said first end of the column wall, a second end plate assembly removably connectable to said second end of the column wall, wherein said first end plate assembly, said column wall and said second end plate assembly are arranged along the longitudinal axis of the column wherein the column wall, and/or first end plate assembly and/or second end plate assembly is/are rotatable about an axis of rotation wherein said axis of rotation is parallel to the longitudinal axis of said column and positioned outside the column
    Type: Application
    Filed: June 4, 2014
    Publication date: September 25, 2014
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: PER LOFVING, MATS OLSSON, SVEN WOUNDER, JERKER PERSSON
  • Micro-RNA scaffolds, non-naturally occurring micro-RNAs, and methods for optimizing non-naturally occurring micro-RNAs
    Patent number: 8841267
    Abstract: The present disclosure provides non-naturally occurring miR-196a-2 miRNAs and non-naturally occurring miR-204 miRNAs. The non-naturally occurring miRNAs of the disclosure have mature strand sequences distinct from their endogenous counterparts. The disclosure also provides methods of selecting mature strand sequences that function optimally in non-naturally occurring miR-196a-2 miRNAs. The methods and compositions of the disclosure may be used to mediate gene silencing via the RNAi pathway.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: September 23, 2014
    Assignee: GE Healthcare Dharmacon, Inc.
    Inventors: Melissa Kelley, Amanda Birmingham, Jon Karpilow, Anastasia Khvorova, Kevin Sullivan
  • Apparatus for mixing the contents of a container
    Patent number: 8840299
    Abstract: An apparatus for mixing materials is disclosed. The apparatus includes a support. A mixing container is disposed in the support, where the mixing container is configured to retain materials. A driver assembly is configured to protrude through the support and into the mixing container. The mixing container includes a paddle, the driver assembly is configured to be attached to the paddle, where the driver assembly is configured to oscillate the paddle in a back and forth direction at a set angle in order to mix the materials in the mixing container.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: September 23, 2014
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Vijay Singh, Willy Papke
  • PARALLEL ASSEMBLY OF CHROMATOGRAPY COLUMN MODULES
    Publication number: 20140263012
    Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
    Type: Application
    Filed: May 29, 2014
    Publication date: September 18, 2014
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventor: KLAUS GEBAUER
  • PROBE ASSEMBLY
    Publication number: 20140260712
    Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid vessel or tubing having a distal aseptic connector for coupling to the vessel or tubing, the probe sheath comprising at least a portion that is rigid, the probe sheath extending longitudinally from the aseptic connector and having at least one inner longitudinal lumen configured to receive an elongate sensor or probe body and to permit longitudinal movement of the sensor/probe body within the probe sheath lumen, and an actuator for deploying a probe within the vessel or tubing by advancing the probe body through the aseptic connector to a position where the probe can measure at least one parameter within the vessel or tubing is disclosed herein.
    Type: Application
    Filed: October 28, 2012
    Publication date: September 18, 2014
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Richard L. Damren, Colin R. Tuohey, Thomas Erdenberger, Michael Fisher, Jonathan A. Kenney, Parrish M. Galliher, Joseph D. Crowell
  • PURIFICATION OF NUCLEIC ACID
    Publication number: 20140272999
    Abstract: The present invention relates to a simple and efficient method to isolate and purify nucleic acids, preferably genomic DNA, from complex samples compared with available methods, by using a ligand which relies on hydrogen bonding to purify the nucleic acids. Preferably the ligand is bound to magnetic beads/particles. More closely the method comprises adding a sample comprising nucleic acid to a polymer having neutral charge; reversibly binding said nucleic acid to said polymer by hydrogen bonding under pH conditions <5; washing said polymer; and eluting said nucleic acid from said polymer under conditions of pH >5. The method is very suitable for sample preparation of nucleic acids, for example for PCR applications.
    Type: Application
    Filed: October 25, 2012
    Publication date: September 18, 2014
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Camilla Estmer Nilsson, Johan Ohman
  • SOLID MATRIX FOR THE STORAGE OF BIOLOGICAL SAMPLES
    Publication number: 20140272983
    Abstract: The present invention relates to a method for storage and subsequent lysis of a sample in which the sample is immobilized on a solid support. The solid matrix is embedded with a low concentration of both a chaotropic salt and a surfactant which act synergistically to efficiently store and lyse a biological sample.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: GE HEALTHCARE UK LIMITED
    Inventors: HUGH O'MALLEY, BARRY JOHNSON
  • Imaging method
    Patent number: 8834843
    Abstract: The present invention relates to a method useful in facilitating the identification of fibrogenesis in a subject. The method of the invention is particularly useful when applied as part of a method to diagnose fibrogenesis of the liver. The invention also provides a compound for use in a method for identification of fibrogenesis in a subject A further aspect of the invention is a compound for use in the preparation of a medicament for use in a method for identification of fibrogenesis in a subject.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: September 16, 2014
    Assignee: GE Healthcare Limited
    Inventors: Ben Newton, Salah Chettibi, Magne Solbakken
  • Sample card magazine
    Patent number: D714957
    Type: Grant
    Filed: January 25, 2012
    Date of Patent: October 7, 2014
    Assignee: GE Healthcare UK Limited
    Inventor: Michael John Smith