Patents Assigned to GE Healthcare Bio-Sciences Corp.
  • Patent number: 10731118
    Abstract: Provided is a bioreactor assembly that includes a plurality of cultivation bags at least one flexible temperature control bag having a thermostating fluid, and a tray adapted to rock back and forth around at least one axis. The flexible temperature control bag is mounted on the tray and the cultivation bags are located on the flexible temperature control bag.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: August 4, 2020
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Ralph Stankowski, Asa Lundstrom, Andreas Castan, Michael Miller, Yvette Klingberg
  • Publication number: 20200238282
    Abstract: A fluid handling apparatus for a bioprocessing system includes a first plate having a first surface and a second surface, at least one fluid flow channel formed in the first surface, at least one valve recess formed in the first surface along the at least one fluid flow channel, and at least one fluid passageway extending through the first plate from the at least one fluid flow channel to the second surface, and a sealing layer disposed over the first surface and enclosing the at least one fluid flow channel. The at least one valve recess is configured to cooperate with an actuator and the sealing layer to prevent a flow of fluid through the at least one fluid flow channel.
    Type: Application
    Filed: January 24, 2019
    Publication date: July 30, 2020
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Andrew Arthur Paul Burns, Dennis Cherok, Mark Timmins, Pei-Hsin Kuo, Weston Blaine Griffin
  • Patent number: 10704042
    Abstract: Methods of amplification, purification and detection of nucleic acid sequences especially RNA are described. One aspect of the method involves the hybridisation and subsequent ligation of a nucleic acid structure to the nucleic acid sequence desired to be manipulated. The methods require that the nucleic acid structure comprises a double stranded region and a single stranded region. The single stranded region is complementary to the RNA sequence of interest. The double stranded region may also contain additional functionalities which are then used subsequently in the method.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: July 7, 2020
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: John R. Nelson, R. Scott Duthie, Rohini Dhulipala, Gregory A. Grossman, Anuradha Sekher
  • Publication number: 20200199504
    Abstract: A bioreactor vessel includes a first compartment configured to receive a suspension comprising cells and a cell culture medium, for use in a cell processing operation, a second compartment for receiving an overflow of the cell culture medium from the first compartment, and an overflow separating the first compartment from the second compartment, the overflow being configured to maintain a level of the cell culture medium in the first compartment
    Type: Application
    Filed: December 21, 2018
    Publication date: June 25, 2020
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventor: MARK ROBERT TIMMINS
  • Patent number: 10677802
    Abstract: Methods comprising the use of photoactivated chemical bleaching for detecting multiple targets in a biological sample are provided. The methods include the steps of binding at least one probe to one or more target present in a biological sample including multiple targets, and detecting a signal from the probe. The method further includes the steps of contacting the sample comprising the bound probe with a photoinitiator and irradiating the sample, thereby initiating a photoactivated chemical bleaching process that substantially inactivates the probe. The method further includes the steps of binding at least one probe to one or more target present in the sample, and detecting a signal from the probe. The process of binding, detecting and bleaching may be iteratively repeated.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: June 9, 2020
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Anup Sood, Arunkumar Natarajan, Lakshmi Sireesha Kaanumalle, Christina Lowes
  • Patent number: 10670490
    Abstract: The present invention relates to a method for a measurement system configured to test a flexible bio-process bag, the method comprising providing at least one flexible bio-process bag having a volume, wherein the at least one flexible bio-process bag is initially filled with a gas and inflated to a reference pressure (Pu), obtaining a leak model, obtaining baseline information, wherein the baseline information comprises at least a weighed first mass value (mbaseline) and a first time value (t1), obtaining evaluation information, wherein the evaluation information comprises at least a weighed second mass value (mevaluation) and a second time value (t2), testing the flexible bio-process bag based on the leak model, the baseline information and the evaluation information.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: June 2, 2020
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Robert Douglas Burchesky, James Molloy
  • Publication number: 20200148987
    Abstract: A bioreactor vessel includes a body having upper and lowerends and a hollow interior cavity formed in the body, the interior cavity located between the upper and lower ends, the interior cavity being configured to receive biomaterials for processing. The interior cavity includes a lower boundary that is angled toward the lower end of the body such that the vessel may be tilted to allow biomaterials within the interior cavity to be extracted and. concentrated and/or washed without the need for a separate bioprocessing device.
    Type: Application
    Filed: November 13, 2018
    Publication date: May 14, 2020
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: REGINALD DONOVAN SMITH, Chengkun Zhang, Jason Castle, Kenneth Conway
  • Publication number: 20200140805
    Abstract: Methods, apparatus, systems and articles of manufacture are disclosed herein to implement flexible bioreactor control systems. An example apparatus disclosed herein includes a processor coupled to a memory, the processor programmed to determine whether the map value included in the process task object is a valid map value, the process task object to correspond to a task executed by a bioreactor, a control device or a measurement device of the bioreactor control system configuration, in response to determining the map value is a valid map value, decode the map value to identify the source location of a first input of the process task object, pull a value from the source location to update the input value of the process task object, and facilitate execution of the process task with the input value.
    Type: Application
    Filed: November 6, 2019
    Publication date: May 7, 2020
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventor: SCOTT A. MANGIACOTTI
  • Patent number: 10639237
    Abstract: The present disclosure relates to aseptic connectors with integrated wireless connectivity. For example, an example system may include a removable clamp configured to secure a first portion of an aseptic connector to a second portion of the aseptic connector. The removable clamp may include a housing, a controller disposed within the housing, a rechargeable battery disposed within the housing, a wireless radio disposed within the housing, and a sensor plug receptacle configured to receive a sensor plug coupled to a sensor of the aseptic connector. The controller may be configured to determine a sensor output of the sensor and to transmit the output using the wireless radio.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: May 5, 2020
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Vincent Francis Pizzi, Christopher Dakin McCoy
  • Publication number: 20200102204
    Abstract: An apparatus for minimizing dead leg spaces in a container or tubing includes a first member having a flange for attaching the first member to a wall of the container or tubing, the flange having at least one aperture, and a second member rotatably coupled to the first member, the second member having an upper end having at least one aperture, and an open distal end. The second member is rotatable relative to the first member between a closed position where the at least one aperture of the second member is misaligned with the at least one aperture in the flange to prevent the passage of fluid, and an open position where the at least one aperture of the second member is aligned with the at least one aperture in the flange to allow for the passage of fluid.
    Type: Application
    Filed: September 27, 2018
    Publication date: April 2, 2020
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Hanna-Leena Saukkonen, Benjamin Brown, Matthew Ouellette, Shanice Jones, Ralph Stankowski, Eric Faldt, Lauren Lisle
  • Patent number: 10597697
    Abstract: The invention discloses a method for determining a nucleotide sequence of a nucleic acid segment present in a biological sample, comprising the steps of: a) generating a fluorescent image of the sample by a protocol comprising immunofluorescence detection of at least five different target proteins in the sample; b) selecting a region of interest of the sample by comparing the image to a predetermined criterion; c) removing a subsample from the region of interest, and; d) determining a nucleotide sequence of a nucleic acid segment present in the subsample.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: March 24, 2020
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: John Richard Nelson, Qingyan Au, Wei Gao, Ryan Charles Heller, Nicholas Hoe, Nam Tran, Nichole Lea Wood
  • Publication number: 20200030719
    Abstract: Methods and systems for chromatography are disclosed that employ a flexible container configured to fit within a support structure and adapted to receive a filtration or absorptive medium. The flexible container can include at least one inlet, at least one outlet, and a separation barrier peripherally sealed within the container to separate the container into a resin containing portion and a drainage portion. The barrier can be configured to exclude the resin material from the drainage portion while allowing fluids to pass therethrough. The disposable chromatography system can further include one or more agitators disposed within the flexible container and adjustably configured to be raised or lowered in the flexible container. When the agitator is in the raised position, the resin packing material can operate in a settled, packed-bed configuration. Alternatively, the agitator in the lowered position permits the chromatography resin packing material to operate in a mixed, slurry configuration.
    Type: Application
    Filed: October 1, 2019
    Publication date: January 30, 2020
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: JOHN J. VICALVI, JOSEPH MAKOWIECKI, JOSEPH D. CROWELL, PARRISH M. GALLIHER
  • Patent number: 10519409
    Abstract: A fluid transfer assembly for single use bioreactors includes a fluid transfer housing that can be mounted to the impeller shaft using a bearing that places the fluid transfer assembly directly below the lowest impeller but allows the impeller shaft to spin inside independently of the fluid transfer assembly. A fluid conduit connects the fluid transfer housing to a port in the single use bag wall which allows fluids to be introduced into the sparger and which also helps prevent the fluid transfer assembly from rotating with the impeller shaft.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: December 31, 2019
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Richard Lee Damren, Colin R. Tuohey
  • Patent number: 10501719
    Abstract: Methods, apparatus, systems and articles of manufacture are disclosed herein to implement flexible bioreactor control systems. An example apparatus disclosed herein includes a processor coupled to a memory, the processor programmed to determine whether the map value included in the process task object is a valid map value, the process task object to correspond to a task executed by a bioreactor, a control device or a measurement device of the bioreactor control system configuration, in response to determining the map value is a valid map value, decode the map value to identify the source location of a first input of the process task object, pull a value from the source location to update the input value of the process task object, and facilitate execution of the process task with the input value.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: December 10, 2019
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventor: Scott A. Mangiacotti
  • Publication number: 20190367856
    Abstract: A bioreactor system includes a vessel having a bottom floor, a flexible bioprocessing bag disposed within the vessel, and a flexible bladder positioned intermediate the bottom floor of the vessel and the bioprocessing bag. The flexible bladder is selectively inflatable to vary at least one of a geometry or configuration of the bioprocessing bag to provide for improved drainability or an increased turndown ratio for the bioreactor system.
    Type: Application
    Filed: May 30, 2018
    Publication date: December 5, 2019
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventor: ALEXANDER MARK KILAR
  • Patent number: 10481375
    Abstract: Disclosed is an optical arrangement providing selective plane illumination, including an inverted illumination objective mounted below a sample support in use providing a line or plane of light at the sample support, and at least one image collection objective mounted above the support, said inverted illumination objective having an illumination objective optic axis, and said image collection objective having an image collection objective optical axis, wherein illumination light is arranged to propagate toward the illumination objective lateral offset to the illumination objective optical axis such that the illumination light leaving the illumination objective propagates toward the sample support at an oblique angle relative to the illumination objective optical axis, and wherein the image objective optical axis has an angle ? which is obtuse to the illumination objective optical axis and generally perpendicular to light propagating at the sample support.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: November 19, 2019
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventor: Jeremy R. Cooper
  • Patent number: 10463988
    Abstract: Methods and systems for chromatography are disclosed that employ a flexible container configured to fit within a support structure and adapted to receive a filtration or absorptive medium, such as a chromatography resin. The flexible container can include at least one inlet, at least one outlet, and a separation barrier peripherally sealed within the container to separate the container into a resin containing portion and a drainage portion. The barrier can be configured to exclude the resin material from the drainage portion during use while allowing fluids to pass therethrough. The disposable chromatography system can further include one or more agitators disposed within the flexible container and adjustably configured to be raised or lowered in the flexible container. When the agitator is in the raised position, the resin packing material can operate in a settled, packed-bed configuration.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: November 5, 2019
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: John J. Vicalvi, Joseph Makowiecki, Joseph D. Crowell, Parrish M. Galliher
  • Patent number: D867119
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: November 19, 2019
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Eric Tenander, Ethan Michael Barrieau, Ralph Stankowski
  • Patent number: D867867
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: November 26, 2019
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Eric Tenander, Ethan Michael Barrieau, Ralph Stankowski
  • Patent number: D877897
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: March 10, 2020
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventor: Matthew David Ouellette