Abstract: The drum coater comprises a substantially cylindrical drum (11) with a peripheral wall and a substantially horizontal axis of rotation. The method comprises providing a coating zone within the drum, feeding tablets into the drum, spinning the drum containing the tablets at a rotational speed such that a substantially annular bed of tablets is created, providing means for creating a cascade (19) of tablets at least in a part of the coating zone and spraying the tablets in the coating zone.
Abstract: A method for continuous production of tablets, including providing a contained module comprising at least two inlets, at least one mixing unit, at least one analytical sensor, a tablet press, and at least one outlet for tablets, feeding an active pharmaceutical ingredient (API) to one of the at least two inlets, feeding an excipient to the other of the at least two inlets, mixing the material stream comprising the API and the excipient in the at least one mixing unit, measuring parameters of the contents of the material stream with the at least one analytical sensor upstream of the tablet press, controlling the two inlets and/or the mixing unit in response to the parameters measured, continuously supplying the tablet press with the material stream, controlling the speed of the tablet press in response to the parameters measured upstream of the tablet press, and discharging tablets at the at least one outlet.
Type:
Application
Filed:
July 7, 2016
Publication date:
October 27, 2016
Applicant:
GEA Pharma Systems Limited
Inventors:
Jurgen BOECKX, Trevor Gordon PAGE, Michel Simon WALDRON
Abstract: The contained module (1) comprises inlets for an active pharmaceutical ingredient (API) and for an excipient. The inlets are in fluid communication with at least one mixing unit (41,46), and the outlet of the tablet press (6) is in fluid communication with the releasable outlet port for tablets. The material stream comprising the API and the excipient is mixed in the mixing units. During operation parameters of the contents of the material stream are measured with one or more analytical sensors upstream of the tablet press. The speed of the tablet press is controlled in response to the parameters measured upstream of the tablet press. The finished tablets are discharged at an outlet of the tablet press (6).
Type:
Application
Filed:
May 7, 2009
Publication date:
March 15, 2012
Applicant:
GEA Pharma Systems Limited
Inventors:
Jurgen Boeckx, Trevor Gordon Page, Michel Simon Waldron