Abstract: The invention relates to a process for the production of compounds of general formula (I), wherein R1 is a —NH-tert-butyl group or a 4-methyl-piperidino group, by bioconversion of compounds of general formula (II), wherein R1 is as described above, using a biocatalyst having steroid-&Dgr;1-dehydrogenase enzyme activity, wherein the activity of the enzyme needed for the bioconversion is produced by induction.
Type:
Grant
Filed:
May 6, 2003
Date of Patent:
July 13, 2004
Assignee:
Gedeon Richter, Ltd.
Inventors:
Katalin Olasz, Ágnes Pécsne Rázsó, István Barthó, Mónika Berta Hériné, Tamás Dávényi, Gábor Hantos