Abstract: A hemostatic putty for treatment of a variety of wounds topographies, including but not limited to highly three dimensional wounds, for example gunshot wounds and impalements, is disclosed. The putty is comprised of a matrix polymer weakly crosslinked or not crosslinked such that a viscoelastic matrix is formed. The viscoelastic nature of the putty is tunable by the composition and enables the putty to conform to a variety of wound topographies. Likewise, a hemostatic polymer, for example chitosan or hydrophobically modified chitosan, is included in this matrix to impart hemostatic properties and tissue adhesive on the putty. The hemostatic polymers disclosed prevent microbial infection and are suitable for oxygen transfer required during normal wound metabolism.
Type:
Grant
Filed:
February 27, 2017
Date of Patent:
December 3, 2019
Assignees:
GEL-E, Inc., University of Maryland, College Park, The General Hospital Corporation
Inventors:
Kevin Diehn, Matthew Dowling, Srinivasa R. Raghavan, David R. King
Abstract: A hemostatic putty for treatment of a variety of wounds topographies, including but not limited to highly three dimensional wounds, for example gunshot wounds and impalements, is disclosed. The putty is comprised of a matrix polymer weakly crosslinked or not crosslinked such that a viscoelastic matrix is formed. The viscoelastic nature of the putty is tunable by the composition and enables the putty to conform to a variety of wound topographies. Likewise, a hemostatic polymer, for example chitosan or hydrophobically modified chitosan, is included in this matrix to impart hemostatic properties and tissue adhesive on the putty. The hemostatic polymers disclosed prevent microbial infection and are suitable for oxygen transfer required during normal wound metabolism.
Type:
Grant
Filed:
March 13, 2014
Date of Patent:
April 11, 2017
Assignees:
Gel-E, Inc., University of Maryland, College Park, The General Hospital Corporation
Inventors:
Kevin Diehn, Matthew Dowling, Srinivasa R. Raghavan, David R. King