Abstract: The invention relates to a novel stable form of cephradine, processes for its production and intermediates used therein.

Abstract: The invention relates to activated aminothiazolyl-oximinoacetic acid derivatives, their production and their use in the production of e.g. amides, in particular cephalosporin antibiotics.

Abstract: A new compound called N,N'-carbonyl-bis-(4-ethyl-2,3-dioxo)-piperazine of Formula I ##STR1## A process for the preparation thereof based on the reaction of 4-ethyl-2,3-dioxo-piperazine or a trimethylsilyl derivative thereof with carbonyl chloride or a derivative thereof.The use of the compound of Formula I as an intermediate in the preparation of compounds of Formula II ##STR2## where R is a radical, substituted in alpha position, of a molecule of an acid selected from the group formed by phenylacetic acid, p-hydroxy phenylacetic acid, a 6-(phenylacetamido)-penicillanic acid and a 7-(phenylacetamido)-cephalosporanic acid.

Abstract: An improved process is disclosed for the preparation of 7-amino and 7-substituted amino-desacetoxycephalosporins in which the corresponding 6-substituted amino penicillin sulphoxide is heated in the presence of an acidic substance which causes expansion of the penam ring in the reactant to the .DELTA..sup.3 cephem ring in the product in the presence of a silicon containing compound. The process comprises adding sulphamide or a silylsulphamide or a silylsulphamoyl to the reaction or utilizing a silylsulphamide or silylsulphamoyl as the silicon containing compound.

Abstract: Amino-beta-lactamic acid salts, having the formula: ##STR1## wherein: (X-Y) may form a system having from 1 to 3 carbon atoms, with or without double bond, (a) closed, in which: X is an atom selected from among carbon, oxygen, nitrogen and sulphur; Y is methylene; Z is a carboxy, sulphonic or phosphonic group (b) open, which may comprise a double bond, in which: X is an atom of hydrogen or a methyl, hydroxymethyl or thiol group, Y is an acid radical chosen from the group formed by sulphonic, phosphonic and sulphoamidic acid; Z is missing. R is an atom or hydrogen, or a methoxyl or ethoxyl group. R.sub.1 is, when present, methyl, acetoxymethyl, acylthiomethyl, such as acetyl and benzoyl derivatives, methoxy, chlorine, carbamoyloxymethyl, azido, azidomethyl (alpha, beta)-thioethylamine or a thiomethyl-heterocyclic derivative of the thiazole, thiadiazole, triazole, tetrazole, oxazole, oxadiazole, pyrimidine and imidazole nuclei. R.sub.2 is an atom of hydrogen or a methyl, ethyl, benzyl or phenyl group.

Abstract: A 3-substituted 7-aminocephalosporanic acid of formula: ##STR1## where R.sub.1 is hydrogen, methyl of methoxy, Y is nitrogen, oxygen sulphur or a sulphoxide group, R.sub.2 is a group selected from among azide or from a radical having the formula R.sub.3 --S-- where R.sub.3 may be, among others, alkyl, aliphatic acyl, methyl and chlorine or methoxy substituted aromatic acyl, is prepared. A compound of formula ##STR2## (X being chlorine, carbamoyloxy or acetoxy) is added to a medium constituted by water, a compound which may be nitric acid or a compound of formula R.sub.3 --SH and a tertiary organic base. With a reaction isoelectric pH regulator, the mixture takes on a specific process pH analytical profile, the compounds of said mixture being reacted together at particular temperatures and with a specific process time.

Abstract: A process for the preparation of solutions of 7-aminocephalosporanic acids wherein there is obtained a salt of the general formula III: ##STR1## where R.sub.1 may be a group selected from among hydrogen, methyl, or a low molecular weight alkoxy, R.sub.2 is a group selected from among methyl, methoxy, azido, chlorine, carbamoylmethyl, acetoxy, thiomethyl, phenylthiomethyl and others, x means from 3 to 5 carbon atoms and y means from 2 to 4 carbon atoms is disclosed. The process is based on the reaction of a compound of formula I ##STR2## with a bicyclic amidine.

Abstract: There is described a process for the preparation of 7-(D(-)-alpha-amino-p-hydroxyphenylacetamido)desacetoxycephalosporanic acid in which a D(-)-p-hydroxy-N-(1-alcoxycarbonyl-2-propenyl)-alpha-aminophenylacetic acid salt is reacted with trimethylsilyl-2-oxazolidinone. The resulting reaction product is reacted in turn with an acyl chloride or an alkyl chloroformate to give a mixed anhydride which is reacted with a solution of 7-aminodesacetoxycephalosporanic acid prepared by silylation, in an anhydrous organic solvent, with trimethylsilyl-2-oxazolidinone.