Patents Assigned to Gen-Probe
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Patent number: 12071615Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.Type: GrantFiled: September 27, 2021Date of Patent: August 27, 2024Assignee: Gen-Probe IncorporatedInventors: Kui Gao, Jijumon Chelliserry, Jeffrey Linnen
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Patent number: 12072342Abstract: A laboratory automated system can include a host conveyor assembly configured to transport a plurality of carriers and receptacles coupled thereto between at least a sample processing instrument and at least one assay instrument. The system includes an intermediate conveyor assembly configured to transport a plurality of carriers and receptacles coupled thereto from within sample processing instrument to the host conveyor assembly. The system also includes an intermediate conveyor assembly for each assay instrument configured to transport a plurality of carriers from host conveyor assembly to a respective processing position within the assay instrument. The intermediate conveyor assembly coupled to the assay instrument can include a buffer conveyor subassembly configured to receive carriers from the host conveyor assembly, and a spur conveyor assembly configured to transport a carrier to the processing position of the assay instrument.Type: GrantFiled: December 1, 2017Date of Patent: August 27, 2024Assignee: GEN-PROBE INCORPORATEDInventor: Gary Lair
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Patent number: 12065694Abstract: Kits for detecting analyte polynucleotides and an internal control in a sample. Included in the kit are an internal control polynucleotide and amplification reagents to co-amplify a first analyte polynucleotide and the internal control. Also included are first and second hybridization probes, each having a label indistinguishable from the other. The probes are respectively capable of hybridizing with a first analyte amplicon and an internal control amplicon. The first and second labels are indistinguishable homogeneous labels.Type: GrantFiled: July 29, 2021Date of Patent: August 20, 2024Assignee: GEN-PROBE INCORPORATEDInventors: Sunghae A. Joo, Janel M. Dockter
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Patent number: 12065693Abstract: The present invention provides compositions, kits and methods for the selective hybridization and capture of a specific target nucleic acid. The specific target nucleic acid may be present in a heterogeneous mixture of nucleic acids. Selective hybridization and capture provides a target nucleic acid that is substantially free of non-target and/or contaminating nucleic acids. Target nucleic acids that have been selectively hybridized and captured using the current invention are then used in subsequent analysis, wherein the presence of non-target and/or contaminating nucleic acids that interfere with said subsequent analysis have been substantially reduced or eliminated, thereby providing improved analysis results.Type: GrantFiled: October 1, 2020Date of Patent: August 20, 2024Assignee: Gen-Probe IncorporatedInventors: Michael M. Becker, Kristin W. Livezey, Wai-Chung Lam
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Patent number: 12054793Abstract: Oligomer nucleotides, compositions, methods, kits, and uses are provided for detecting or quantifying a human polyomavirus BK virus (BKV) nucleic acid, e.g., using nucleic acid amplification and hybridization assays.Type: GrantFiled: October 22, 2019Date of Patent: August 6, 2024Assignee: GEN-PROBE INCORPORATEDInventors: Ankur Shah, Meghna Yadav
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Publication number: 20240254572Abstract: Disclosed are formulations and reaction mixtures comprising at least one polymerase, ?-cyclodextrin, and polysorbate 20. Also disclosed are related methods for preparing the disclosed formulations and reaction mixtures, as well as related kits and methods for nucleic acid amplification. The formulations and reaction mixtures are useful, for example, in mitigating the inhibitory effect of sample extraction detergents on nucleic acid amplification reactions.Type: ApplicationFiled: June 29, 2022Publication date: August 1, 2024Applicant: Gen-Probe IncorporatedInventors: Vincent J. CHABOT, Mark E. FILIPOWSKY
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Patent number: 12037638Abstract: Presented are methods, systems, and software products useful for determining the concentration of an analyte in a fluid specimen used to produce a dried sample, where the dried sample serves as a source of the analyte in a detection and quantification procedure. Particularly illustrated is the use of dried blood spots for quantifying a polynucleotide analyte.Type: GrantFiled: December 9, 2020Date of Patent: July 16, 2024Assignee: GEN-PROBE INCORPORATEDInventors: Sangeetha Vijaysri Nair, Xianqun Wang
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Patent number: 12031187Abstract: Disclosed are methods for diagnosing Bacterial Vaginosis in a subject comprising performing an assay for the detection of any one or more of Lactobacillus sp., Gardneralla vaginalis, and Eggerthella sp. in a subject sample. Also disclosed are methods and compositions for detecting Lactobacillus sp., Gardneralla vaginalis, and/or Eggerthella nucleic acid in a sample.Type: GrantFiled: May 24, 2021Date of Patent: July 9, 2024Assignee: GEN-PROBE INCORPORATEDInventors: Barbara Lynn Eaton, Damon Kittredge Getman, Traci Pawlowski
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Patent number: 12031003Abstract: The disclosure provides solid compositions such as lyophilisates adhered to surfaces such as plasma-treated surfaces and related methods, uses, kits, intermediates, starting materials, and downstream products.Type: GrantFiled: October 21, 2020Date of Patent: July 9, 2024Assignee: GEN-PROBE INCORPORATEDInventors: Byron J. Knight, David Opalsky
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Publication number: 20240219415Abstract: A jig assembly for connecting first and second consoles with predefined relative positioning includes first and second positioning pins attached or attachable to the first console and a positioning connection bracket attached or attachable to the second console and including a longitudinal span and first and second transverse legs including first and second pin recesses at respective free ends thereof. The first and second pin recesses receive the first and second positioning pins, respectively, when the first and second consoles are moved laterally toward each other. The first and second transverse legs may be attached to the first console with a first and second leg attachment brackets, respectively. The first and second positing pins and the first and second leg attachment brackets may be fixed with respect to the first console by attachment to a mounting rail that is fixed to the first console.Type: ApplicationFiled: January 18, 2023Publication date: July 4, 2024Applicant: Gen-Probe IncorporatedInventors: Rolf SILBERT, HongRan PENG
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Publication number: 20240201212Abstract: A receptacle delivery system for an instrument includes a carriage, a puck rotatably supported by the carriage, a first electric motor, and a second electric motor. The puck comprises a plurality of spring-loaded fingers arranged around a vertical axis and configured to removably support a receptacle therebetween. The first electric motor is configured to move the carriage between a first location and a second location of the instrument. The second electric motor is configured to rotate the puck about the vertical axis.Type: ApplicationFiled: February 29, 2024Publication date: June 20, 2024Applicant: Gen-Probe IncorporatedInventors: Rolf SILBERT, HongRan PENG, David Aaron BUSE, David H. COMBS
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Publication number: 20240201213Abstract: A receptacle delivery system for an instrument includes a carriage, a puck supported by the carriage, and a first shelf. The carriage is configured to move from a first location of the instrument to a second location of the instrument. The puck is configured to removably support a receptacle such that a longitudinal axis of the receptacle is substantially coincident with a vertical axis of the puck. The first shelf is positioned at the second location of the instrument and comprises (a) a base extending substantially transverse to the vertical axis of the puck and (b) a first opening defined by the base. When the carriage is positioned at the second location, the longitudinal axis of a receptacle seated in the puck extends through the first opening.Type: ApplicationFiled: March 1, 2024Publication date: June 20, 2024Applicant: Gen-Probe IncorporatedInventors: Rolf SILBERT, HongRan PENG, David Aaron BUSE, David H. COMBS
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Publication number: 20240201211Abstract: A method of delivering a receptacle to an instrument includes the steps of supporting a receptacle in a carriage, activating an electric motor to move the carriage between a first location and a second location of the instrument while the receptacle is supported by the carriage, applying a clamping force to the receptacle as the carriage moves from the first location to the second location, and releasing the clamping force from the receptacle as the carriage moves from the second location to the first location.Type: ApplicationFiled: February 29, 2024Publication date: June 20, 2024Applicant: Gen-Probe IncorporatedInventors: Rolf SILBERT, HongRan PENG, David Aaron BUSE, David H. COMBS
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Patent number: 12006930Abstract: A system for managing liquid waste includes a first liquid container that receives waste liquid, a liquid transfer pump fluidly connected to the first liquid container; and a second liquid container fluidly connectable to the liquid transfer pump. The liquid transfer pump is can be selectively activated to transfer liquid waste from the first liquid container to the second liquid container when the second liquid container is fluidly connected to the liquid transfer pump.Type: GrantFiled: April 22, 2020Date of Patent: June 11, 2024Assignee: GEN-PROBE INCORPORATEDInventors: David H. Combs, Ayra A. Baker, Norbert D. Hagen, David A. Buse
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SCISSORS ACTUATOR CONFIGURED TO TRANSLATE A SUPPORT PLATFORM IN EITHER OF OPPOSED LATERAL DIRECTIONS
Publication number: 20240173720Abstract: A scissors actuator is configured to translate a support platform in either of opposed lateral directions with respect to a base frame and includes a first arm, a second arm, wherein the first and second arms are rotatably connected at intermediate positions between their respective first and second ends, the first arm is pivotably attached at its first end to the base frame, and the second arm and is pivotably attached at its second end to the support platform. A first slide is disposed within a first linear track formed in the support platform and includes a bearing protruding from a side of the first slide for rolling contact with a side of the first linear track formed in the support platform. The first arm is pivotably and translatably attached at its second end to the support platform by the first slide.Type: ApplicationFiled: December 29, 2023Publication date: May 30, 2024Applicant: Gen-Probe IncorporatedInventors: Julian GROELI, Jin CHEN -
Patent number: 11994471Abstract: An apparatus for detecting an optical signal emission includes signal transmission fibers. Each fiber includes cores having the same spatial core arrangement at each end. The first ends are configured to be optically coupled to the signal emission sources. Each fiber is configured to transmit an optical signal between the first end and the second. The apparatus can also include a frame assembly securing the first ends of the fibers in a first spatial fiber arrangement corresponding to a spatial arrangement of the signal emission sources. The frame assembly can also secure the second ends of the fibers in a second spatial fiber arrangement different from the first spatial fiber arrangement. The apparatus can also include at least one signal detector configured to be optically coupled to the second ends of the fibers and configured to detect an optical signal emitted by each signal emission source.Type: GrantFiled: January 25, 2023Date of Patent: May 28, 2024Assignee: GEN-PROBE INCORPORATEDInventors: Norbert Hagen, George Walker, David Combs
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Publication number: 20240168044Abstract: A method of delivering a receptacle to an instrument includes the steps of supporting a receptacle containing a fluid on a carrier, transporting the carrier supporting the receptacle on a conveyor extending adjacent to each of a plurality of instruments, transferring the receptacle from the carrier to a puck supported on a carriage when the carriage is positioned at a first location, moving the carriage with the receptacle seated in the puck from the first location to a second location within an instrument of the plurality of instruments, and drawing at least a portion of the fluid from the receptacle seated in the puck into a tip associated with a fluid extraction device of the instrument when the carriage is positioned at the second location.Type: ApplicationFiled: January 31, 2024Publication date: May 23, 2024Applicant: Gen-Probe IncorporatedInventors: Rolf SILBERT, HongRan PENG, David Aaron BUSE, David H. COMBS
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Publication number: 20240168043Abstract: A receptacle delivery system for an instrument includes a carriage, a puck supported by the carriage, and a first shelf. The carriage is configured to move from a first location of the instrument to a second location of the instrument. The puck is configured to removably support a receptacle such that a longitudinal axis of the receptacle is substantially coincident with a vertical axis of the puck. The first shelf comprises (a) a base extending substantially transverse to the vertical axis of the puck and (b) a first opening defined by the base, and when the carriage is positioned at the second location, the longitudinal axis of a receptacle seated in the puck extends through the first opening.Type: ApplicationFiled: January 31, 2024Publication date: May 23, 2024Applicant: Gen-Probe IncorporatedInventors: Rolf SILBERT, HongRan PENG, David Aaron BUSE, David H. COMBS
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Publication number: 20240159972Abstract: An apparatus for incubating the contents of a plurality of receptacles and for detecting a signal emitted by the contents of each of the receptacle includes a plurality of receptacle holders configured to incubate the contents of each a plurality of receptacles held by each of the receptacle holders. A controller is coupled to each of the receptacle holders and is configured to independently control an incubation temperature of each of the receptacle holders to independently control a temperature at which the receptacles held by each of the receptacle holders is incubated. At least one signal detector is configured to detect a signal emitted by the contents of each of the receptacles held in each of the receptacle holders, and a signal detector indexer is configured to successively optically couple each signal detector with each of the receptacles held in each of the receptacle holders to detect optical emissions from each successively coupled receptacle.Type: ApplicationFiled: December 20, 2023Publication date: May 16, 2024Applicant: Gen-Probe IncorporatedInventors: David BUSE, David Howard COMBS, Norbert D. HAGEN, David OPALSKY, Bruce RICHARDSON, Anita PRASAD, Keith MORAVICK, Tyler MOORE
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Patent number: RE49975Abstract: Methods for selecting tag-oligonucleotide sequences for use in an in vitro nucleic acid assay. The selected tag sequences are useful for nucleic acid assay wherein interference between the nucleic acid sequences is the assay is to be controlled. Selected tag sequences are incorporated into nucleic acid assay to improve the performance of and/or minimize any interference between nucleic acids in the assay compared to untagged assays.Type: GrantFiled: September 13, 2021Date of Patent: May 21, 2024Assignee: GEN-PROBE INCORPORATEDInventors: Norman C. Nelson, Jijumon Chelliserry