Patents Assigned to Genapsys, Inc.
  • Patent number: 10266892
    Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: April 23, 2019
    Assignee: GENAPSYS, INC.
    Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
  • Patent number: 10260095
    Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: April 16, 2019
    Assignee: GENAPSYS, INC.
    Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
  • Patent number: 10125393
    Abstract: Provided herein are devices and methods suitable for sequencing, detecting, amplifying, analyzing, and performing sample preparation procedures for nucleic acids and other molecules. In some cases, the devices and methods provided herein are used for computation.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: November 13, 2018
    Assignee: GENAPSYS, INC.
    Inventors: Hesaam Esfandyarpour, Meysam R. Barmi, Kosar B. Parizi, Saurabh Paliwal, Amirhossein Samakar, Seth Stern
  • Patent number: 10100356
    Abstract: A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: October 16, 2018
    Assignee: GENAPSYS, INC.
    Inventors: Hesaam Esfandyarpour, Mark F. Oldham, Kosar Baghbani Parizi, Eric S. Nordman
  • Patent number: 10093975
    Abstract: The present disclosure relates to systems and methods for high efficiency electronic sequencing of nucleic acids and molecular detection. In an example embodiment of the instant disclosure, the NanoNeedle may be utilized to detect a change in impedance resulting from the modulation of the counter ion concentration or Debye length associated with a biomolecule of interest, such as DNA or protein, for an application of interest, such as DNA sequencing, DNA hybridization, or protein detection.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: October 9, 2018
    Assignee: GENAPSYS, INC.
    Inventor: Hesaam Esfandyarpour
  • Patent number: 9926596
    Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: March 27, 2018
    Assignee: GENAPSYS, INC.
    Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
  • Publication number: 20180051332
    Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.
    Type: Application
    Filed: May 29, 2012
    Publication date: February 22, 2018
    Applicant: GENAPSYS, INC.
    Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
  • Patent number: 9822401
    Abstract: The disclosure provides methods and systems for nucleic acid amplification including isothermal nucleic acid amplification.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: November 21, 2017
    Assignee: GENAPSYS, INC.
    Inventor: Florian Oberstrass
  • Patent number: 9809852
    Abstract: Provided herein are devices and methods suitable for sequencing, amplifying, analyzing, and performing sample preparation procedures for nucleic acids and other biomolecules.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 7, 2017
    Assignee: GENAPSYS, INC.
    Inventors: Hesaam Esfandyarpour, Hamid Rategh, Meysam R. Barmi, Kosar B. Parizi, Kambiz Kaviani
  • Patent number: 9630177
    Abstract: The present disclosure provides microfluidic devices, systems and methods for sample preparation and/or analysis. A microfluidic device can include a first channel having a sequence of (n) chambers each having a first volume (v). The first channel can include one or more valves at opposing ends of the first channel that fluidically isolate the first channel. The microfluidic device can further include a second channel in fluid communication with the first channel. The second channel can include at least one second chamber having a total second volume that is at least equal to the total volume of the first channel (n*v). The second channel can include one or more valves at opposing ends of the second channel that fluidically isolate the second channel from the first channel.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: April 25, 2017
    Assignee: GenapSys, Inc.
    Inventors: Seth Stern, Hesaam Esfandyarpour, David Eberhart
  • Patent number: 9533305
    Abstract: A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead is isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: January 3, 2017
    Assignee: GENAPSYS, INC.
    Inventors: Hesaam Esfandyarpour, Mark Oldham
  • Publication number: 20160273032
    Abstract: Provided herein are devices and methods suitable for sequencing, detecting, amplifying, analyzing, and performing sample preparation procedures for nucleic acids and other molecules. In some cases, the devices and methods provided herein are used for computation.
    Type: Application
    Filed: December 10, 2014
    Publication date: September 22, 2016
    Applicant: GENAPSYS, INC.
    Inventors: Hesaam ESFANDYARPOUR, Meysam R. BARMI, Kosar B. PARIZI, Saurabh PALIWAL, Amirhossein SAMAKAR, Seth STERN
  • Patent number: 9399217
    Abstract: Aspects of the invention include methods for improving the accuracy and read length of sequencing reactions by utilizing unlabeled unincorporable nucleotides, or by rephasing colony based sequencing reactions. Other aspects include systems and devices for improved measurement of biological reactions associated with bead which may be removed, utilizing current measurement methods through the counter ions associated with said beads due to the presence of reactants bound or associated with said bead, wherein electrodes for generating and measuring said current may be within the Debye length of said bead. Other aspects of the invention include methods for determining concentrations of input samples, means for reuse of an array, methods and apparatus for separating beads with different charge levels from each other.
    Type: Grant
    Filed: May 27, 2012
    Date of Patent: July 26, 2016
    Assignee: GENAPSYS, INC.
    Inventors: Hesaam Esfandyarpour, Kosar B. Parizi, Mark F. Oldham
  • Patent number: 9274077
    Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 1, 2016
    Assignee: GENAPSYS, INC.
    Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
  • Patent number: 9187783
    Abstract: A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead is isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: November 17, 2015
    Assignee: GENAPSYS, INC.
    Inventors: Hesaam Esfandyarpour, Mark F. Oldham, Eric S. Nordman, Kosar Baghbani Parizi
  • Patent number: 9150915
    Abstract: A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead is isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: October 6, 2015
    Assignee: GENAPSYS, INC.
    Inventors: Hesaam Esfandyarpour, Mark Oldham
  • Patent number: 8969002
    Abstract: The present invention provides for methods and systems for Electronic DNA sequencing, single molecule DNA sequencing, and combinations of the above, providing low cost and convenient sequencing.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: March 3, 2015
    Assignee: Genapsys, Inc.
    Inventors: Hesaam Esfandyarpour, Mark Oldham
  • Publication number: 20140235457
    Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.
    Type: Application
    Filed: May 29, 2012
    Publication date: August 21, 2014
    Applicant: GENAPSYS, INC.
    Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parazi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
  • Publication number: 20140057339
    Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.
    Type: Application
    Filed: March 15, 2013
    Publication date: February 27, 2014
    Applicant: GENAPSYS INC.
    Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parazi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
  • Publication number: 20140045701
    Abstract: A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead is isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat.
    Type: Application
    Filed: October 4, 2011
    Publication date: February 13, 2014
    Applicant: GENAPSYS INC.
    Inventors: Hesaam Esfandyarpour, Mark F. Oldham, Kosar Parazi, Eric Nordman