Abstract: Liquid or frozen compositions containing adenoviral-particles, comprising a buffer solution capable of maintaining the pH of the medium at slightly alkaline values, supplemented with glycerol and without addition of divalent metal cations or of alkali metal cations.
Abstract: The invention concerns recombinant viruses comprising a heterologous DNA sequence under the control of expression signals specifically active in tumor cells, and their preparation and use in the treatment and prevention of cancers.
Type:
Grant
Filed:
November 7, 1994
Date of Patent:
April 25, 2006
Assignee:
Gencell SA
Inventors:
Jean-Francois Dedieu, Aude Le Roux, Michel Perricaudet