Patents Assigned to GenDerm Corporation
  • Patent number: 5840762
    Abstract: The invention relates to the use of zucapsaicin (cis-8-methly-N-vanillly-6-nonenamide), the cis-isomer of capsaicin, to treat myocardial disorders, including the prevention, suppression or reversal of an abnormal cardiac rhythm, such as ventricular tachycardia. In vitro, zucapsaicin exhibits electrophysiologic properties distinct from capsaicin. In contrast to capsaicin, zucapsaicin significantly shortens the action potential duration at a dose of 10.sup.-5 M and has no effect on the amplitude of Phase 1 of the action potential in normal Purkinje cells. Zucapsaicin also prevents the induction of ventricular tachycardia of focal Purkinje origin when given intravenously after coronary occlusion in a dog model of acute myocardial infarction.
    Type: Grant
    Filed: January 12, 1996
    Date of Patent: November 24, 1998
    Assignee: GenDerm Corporation
    Inventors: Joel E. Bernstein, Kenneth M. Verburg
  • Patent number: 5508034
    Abstract: A method and composition for treating and preventing dry skin includes a lipid concentrate blended from a combination of the three naturally-occurring lipid groups found in the stratum corneum. The concentrate may be applied topically as prepared, or may be blended with a therapeutically acceptable vehicle suitable for topical application.
    Type: Grant
    Filed: October 19, 1994
    Date of Patent: April 16, 1996
    Assignee: GenDerm Corporation
    Inventor: Joel E. Bernstein
  • Patent number: 5134166
    Abstract: Compositions and methods for treating the symptoms of certain allergy-related conditions using capsaicin in solution or suspension combined with a selected local anesthetic, topical steroid or antihistamine. The same methods and compositions may be used to treat headaches.
    Type: Grant
    Filed: October 9, 1990
    Date of Patent: July 28, 1992
    Assignee: GenDerm Corporation
    Inventor: Joel E. Bernstein