Patents Assigned to Gene Bridges GmbH
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Patent number: 11866724Abstract: The invention relates to adenoviral vectors, cells for use in generating adenoviral vectors, methods for generating adenoviral vectors, and therapeutic uses of adenoviral vectors in gene therapy, tumour therapy and as vaccines.Type: GrantFiled: April 6, 2017Date of Patent: January 9, 2024Assignee: Gene Bridges GMBHInventors: Adrian Francis Stewart, Jun Fu, Anja Ehrhardt, Eric Ehrke-Schulz, Wenli Zhang
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Publication number: 20190382793Abstract: The invention relates to adenoviral vectors, cells for use in generating adenoviral vectors, methods for generating adenoviral vectors, and therapeutic uses of adenoviral vectors in gene therapy, tumour therapy and as vaccines.Type: ApplicationFiled: April 6, 2017Publication date: December 19, 2019Applicant: Gene Bridges GMBHInventors: Adrian Francis Stewart, Jun Fu, Anja Ehrhardt, Eric Ehrke-Schulz, Wenli Zhang
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Patent number: 10443051Abstract: A method for performing homologous recombination between at least a first nucleic acid molecule and a second nucleic acid molecule which share at least one region of sequence homology. A method for improving the efficiency of homologous recombination.Type: GrantFiled: June 10, 2011Date of Patent: October 15, 2019Assignee: GENE BRIDGES GMBHInventors: Youming Zhang, Jun Fu, Adrian Francis Stewart
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Patent number: 9580717Abstract: This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of polyketide or non-ribosomal peptide synthesis. Methods of treating cancer are also disclosed.Type: GrantFiled: December 17, 2010Date of Patent: February 28, 2017Assignee: Gene Bridges GmbHInventors: Youming Zhang, Jun Fu, Xiaoying Bian, Adrian Francis Stewart, Rolf Müller
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Patent number: 8728820Abstract: The invention provides a method for inserting a single stranded replacement nucleic acid into a target nucleic acid, the method comprising the steps of: a) generating a single stranded replacement nucleic acid from a double stranded nucleic acid, wherein the double stranded nucleic acid is adapted at one or both of its 5? ends such that preferential degradation of one strand and/or strand separation generates the single stranded replacement nucleic acid, wherein the single stranded replacement nucleic acid comprises a 5? region that is identical to sequence on the target nucleic acid, a 3? region that is identical to sequence on the target nucleic acid and optionally a replacement region between the 5? and 3? regions that is not identical to sequence on the target nucleic acid, b) exposing the target nucleic acid to the single stranded replacement nucleic acid under conditions suitable for recombination to occur between the single stranded replacement nucleic acid and the target nucleic acid, and c) selectingType: GrantFiled: February 20, 2009Date of Patent: May 20, 2014Assignee: Gene Bridges GmbHInventors: Marcello Maresca, Axel Steffen Erler, Jun Fu, Philipp Martin Seibert, Adrian Francis Stewart, Youming Zhang
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Publication number: 20130089522Abstract: This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of polyketide or non-ribosomal peptide synthesis. Methods of treating cancer are also disclosed.Type: ApplicationFiled: December 17, 2010Publication date: April 11, 2013Applicant: GENE BRIDGES GMBHInventors: Youming Zhang, Jun Fu, Xiaoying Bian, Francis Stewart, Rolf Muller
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Publication number: 20110165630Abstract: The invention provides a method for inserting a single stranded replacement nucleic acid into a target nucleic acid, said method comprising the steps of: a) generating a single stranded replacement nucleic acid from a double stranded nucleic acid, wherein the double stranded nucleic acid is adapted at one or both of its 5? ends such that preferential degradation of one strand and/or strand separation generates the single stranded replacement nucleic acid, wherein the single stranded replacement nucleic acid comprises a 5? region that is identical to sequence on the target nucleic acid, a 3? region that is identical to sequence on the target nucleic acid and optionally a replacement region between the 5? and 3? regions that is not identical to sequence on the target N nucleic acid, b) exposing the target nucleic acid to the single stranded replacement nucleic acid under conditions suitable for recombination to occur between the single stranded replacement nucleic acid and the target nucleic acid, and c) selectType: ApplicationFiled: February 20, 2009Publication date: July 7, 2011Applicant: Gene Bridges GmbHInventors: Marcello Maresca, Axel Steffen Erler, Jun Fu, Philipp Martin Seibert, Adrian Francis Stewart, Youming Ahang