Abstract: A method is provided for reducing or alleviating inflammation or a pathological process associated therewith or secondary thereto in a subject having an inflammatory disease of the digestive tract. The method comprises administering to the subject an anti-inflammatorily effective amount of an ACE2 inhibitor.

Abstract: A method for selecting a female breast cancer patient for AT1 receptor antagonist therapy comprises (a) determining whether the cancer comprises a tumor that is ER+ and/or PR+; and (b) selecting the patient for AT1 receptor antagonist therapy only if the cancer is determined to comprise an ER+ and/or PR+ tumor. A method for treating breast cancer in a female patient further comprises (c) administering to the patient, if so selected, an AT1 receptor antagonist according to a regimen effective to reduce growth, invasiveness and/or metastasis of the tumor.

Abstract: A method for treating an inflammatory disease of the digestive tract, for example inflammatory bowel disease, in a subject comprises administering to the subject a therapeutically effective amount of a compound selected from the group consisting of (S,S)-2-[1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl]-ethylamino]-4-methylpentanoic acid, pharmaceutically acceptable salts thereof and prodrugs thereof.

Abstract: A platform is for managing, integrating, and analyzing gene expression data. The platform includes a Run Time Engine(RTE) which provides more direct, quicker, and more efficient access to gene expression data through the use of memory mapped files. The platform also includes a workspace that is implemented in directories with data objects comprising XML descriptors coupled with binary data objects for storing gene and sample identifiers and input parameters for saved analysis sessions. The platform provides various Application Programming Interfaces (APIs) to a data warehouse, including a low-level C++ API, a high-level C++ API, a Perl API, R API, and CORBA API to access gene expression data from RTE memory mapped files. These APIs offer quicker and more direct access to the memory, thus improving the speed of overall operations.

Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes and their encoded proteins may be used as toxicity markers in drug screening and toxicity assays. The invention also includes a database of genes and/or proteins characterized by toxin-induced differential expression.

Abstract: The invention described herein relates to computer and display methods and systems for acquiring, storing, manipulating, analyzing, linking, retrieving and displaying the data. The methods and systems are illustrated with reference to data on constituents of biological systems, particularly data on gene expression. In this regard, the invention especially relates to interactive systems for displaying gene expression-related data in three-dimensional molecular topographies. Expressed genes and their activity are represented as peaks in the topographies. Additionally, the invention relates to methods and systems for generating and displaying delta plots, which show differences in gene expression, and to methods and systems for generating molecular movies that show changes in gene expression. While illustrated by reference to gene expression, the methods and systems can be used to generate and manipulate displays of data on other complex populations.

Abstract: Methods for identifying functional allele profiles of a given gene are disclosed. Functional allele profiles comprise the commonly occurring alleles in a population, and the relative frequencies at which such alleles of a given gene occur. Functional allele profiles are useful in treatment and diagnosis of diseases, for genetic and pharmacogenetic applications and for evaluating the degree to which the gene(s) are under selective pressure.

Abstract: A multi-database query system which queries a plurality of databases and servers, including an input which receives queries in a structured form and a translation server which translates at least a part of a received query into commands recognized by a data manipulation server.

Abstract: isolated coding sequences and to the protein sequences they code for. This invention is directed to three coding sequence of the BRCA1 gene. The three coding sequences, BRCA1(omi1), BRCA1(omi2), and BRCA1(omi3) and their frequencies of occurrence are provided together with the protein sequences they code for. Another aspect of this invention is a method of determining the consensus sequence for any gene. Another aspect of the invention is a method of identifying an individual having an increased genetic susceptibility to breast or ovarian cancer because they have inherited a causative mutation in their BRCA1 gene. This invention is also related to a method of performing gene therapy with any of the isolated BRCA1 coding sequences.

Abstract: The invention is directed to isolated coding sequences and to the protein sequences they code for. The coding sequence for BRCA1(omi4) gene is provided together with the protein sequence it codes for. The BRCA1(omi4) sequence is used for identifying an individual having an increased genetic susceptibility to breast or ovarian cancer because the patient has an inherited causative mutation in their BRCA1 gene. This invention is also related to a method of performing gene therapy with the isolated BRCA1(omi4) coding sequence and protein replacement therapy with the BRCA1(omi4) protein.