Patents Assigned to Gene Logic Inc.
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Publication number: 20080234345Abstract: A method is provided for reducing or alleviating inflammation or a pathological process associated therewith or secondary thereto in a subject having an inflammatory disease of the digestive tract. The method comprises administering to the subject an anti-inflammatorily effective amount of an ACE2 inhibitor.Type: ApplicationFiled: September 7, 2007Publication date: September 25, 2008Applicant: Gene Logic Inc.Inventors: Louis Anthony Tartaglia, Thomas Michael Barnes, Robert Mark Coopersmith, Scott Edward Malstrom, David William White, Dominic Picarella
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Publication number: 20080132474Abstract: A method for selecting a female breast cancer patient for AT1 receptor antagonist therapy comprises (a) determining whether the cancer comprises a tumor that is ER+ and/or PR+; and (b) selecting the patient for AT1 receptor antagonist therapy only if the cancer is determined to comprise an ER+ and/or PR+ tumor. A method for treating breast cancer in a female patient further comprises (c) administering to the patient, if so selected, an AT1 receptor antagonist according to a regimen effective to reduce growth, invasiveness and/or metastasis of the tumor.Type: ApplicationFiled: November 6, 2007Publication date: June 5, 2008Applicant: Gene Logic Inc.Inventors: Robert Mark Coopersmith, David William White, Shengfang Jin, Denzyl Fernandes, Xuena Lin
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Publication number: 20080107650Abstract: A method for treating an inflammatory disease of the digestive tract, for example inflammatory bowel disease, in a subject comprises administering to the subject a therapeutically effective amount of a compound selected from the group consisting of (S,S)-2-[1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl]-ethylamino]-4-methylpentanoic acid, pharmaceutically acceptable salts thereof and prodrugs thereof.Type: ApplicationFiled: September 7, 2007Publication date: May 8, 2008Applicant: Gene Logic Inc.Inventors: Louis Tartaglia, Thomas Barnes, Robert Coopersmith, Scott Malstrom, David White, Dominic Picarella
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Patent number: 7321830Abstract: The present invention relates to a computer system comprising a database for elucidating changes in gene expression in prostate tissue isolated from patients exhibiting different clinical states of prostate hyperplasia as compared to normal prostate tissue, as well as the identification of individual genes that are differentially expressed in diseased prostate tissue.Type: GrantFiled: September 24, 2001Date of Patent: January 22, 2008Assignees: Gene Logic, Inc., University of PittsburghInventors: William E. Munger, Prakash Kulkarni, Robert H. Getzenberg, Iwao Waga, Jun Yamamoto
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Publication number: 20070293498Abstract: This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic illnesses. The compounds are represented by formula I: wherein X is oxygen or sulfur; G is G1 or G2: L1, L2, L3 and Q are linker groups, and Rings A, B and C, and R1-R14 are described in the specification. The compounds are antagonists of melanocortin receptors.Type: ApplicationFiled: July 26, 2007Publication date: December 20, 2007Applicant: Gene Logic, Inc.Inventors: Tricia Vos, Michael Patane, Michael Solomon, Christopher Blackburn, Mihaela Danca
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Patent number: 7251642Abstract: A platform is for managing, integrating, and analyzing gene expression data. The platform includes a Run Time Engine(RTE) which provides more direct, quicker, and more efficient access to gene expression data through the use of memory mapped files. The platform also includes a workspace that is implemented in directories with data objects comprising XML descriptors coupled with binary data objects for storing gene and sample identifiers and input parameters for saved analysis sessions. The platform provides various Application Programming Interfaces (APIs) to a data warehouse, including a low-level C++ API, a high-level C++ API, a Perl API, R API, and CORBA API to access gene expression data from RTE memory mapped files. These APIs offer quicker and more direct access to the memory, thus improving the speed of overall operations.Type: GrantFiled: August 6, 2002Date of Patent: July 31, 2007Assignee: Gene Logic Inc.Inventor: Ernest Szeto
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Publication number: 20070055448Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes and their encoded proteins may be used as toxicity markers in drug screening and toxicity assays. The invention also includes a database of genes and/or proteins characterized by toxin-induced differential expression.Type: ApplicationFiled: August 9, 2004Publication date: March 8, 2007Applicant: Gene Logic Inc.Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Orr, Michael Elashoff
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Patent number: 7031843Abstract: The invention described herein relates to computer and display methods and systems for acquiring, storing, manipulating, analyzing, linking, retrieving and displaying the data. The methods and systems are illustrated with reference to data on constituents of biological systems, particularly data on gene expression. In this regard, the invention especially relates to interactive systems for displaying gene expression-related data in three-dimensional molecular topographies. Expressed genes and their activity are represented as peaks in the topographies. Additionally, the invention relates to methods and systems for generating and displaying delta plots, which show differences in gene expression, and to methods and systems for generating molecular movies that show changes in gene expression. While illustrated by reference to gene expression, the methods and systems can be used to generate and manipulate displays of data on other complex populations.Type: GrantFiled: September 23, 1998Date of Patent: April 18, 2006Assignee: Gene Logic Inc.Inventors: Brian R. Bullard, Sean Mullins
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Patent number: 7020561Abstract: The present invention provides systems and methods for analyzing gene expression, gene annotation, and sample information in a relational format supporting efficient exploration and analysis, including comparative differential expression analysis, expression pattern matching, and mapping of external attributes or identifiers to internal representations of gene fragments or samples.Type: GrantFiled: August 5, 2002Date of Patent: March 28, 2006Assignee: Gene Logic, Inc.Inventors: Kevin McLoughlin, Francois Collin, Victor M. Markowitz, Thodoros Topaloglou, Alexandros Athanasopoulos
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Patent number: 6974667Abstract: The present invention identifies the global changes in gene expression associated with liver cancer by examining gene expression in tissue from normal liver, metastatic malignant liver and hepatocellular carcinoma. The present invention also identifies expression profiles which serve as useful diagnostic markers as well as markers that can be used to monitor disease states, disease progression, drug toxicity, drug efficacy and drug metabolism.Type: GrantFiled: June 14, 2001Date of Patent: December 13, 2005Assignee: Gene Logic, Inc.Inventors: Darci T. Horne, Uwe Scherf, Joseph Vockley
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Patent number: 6951721Abstract: Methods for identifying functional allele profiles of a given gene are disclosed. Functional allele profiles comprise the commonly occurring alleles in a population, and the relative frequencies at which such alleles of a given gene occur. Functional allele profiles are useful in treatment and diagnosis of diseases, for genetic and pharmacogenetic applications and for evaluating the degree to which the gene(s) are under selective pressure.Type: GrantFiled: August 8, 2001Date of Patent: October 4, 2005Assignee: Gene Logic Inc.Inventor: Patricia D. Murphy
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Patent number: 6931396Abstract: A multi-database query system which queries a plurality of databases and servers, including an input which receives queries in a structured form and a translation server which translates at least a part of a received query into commands recognized by a data manipulation server.Type: GrantFiled: June 28, 2000Date of Patent: August 16, 2005Assignee: Gene Logic Inc.Inventors: Thodoros Topaloglou, Anthony Kosky
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Publication number: 20050170375Abstract: This application concerns improved methods of analyzing gene expression data where mRNA transcripts or representatives thereof that skew the gene expression profile of a cell or tissue sample are identified and removed from the population of mRNA transcripts prior to, during or subsequent to a reverse transcription reaction.Type: ApplicationFiled: September 24, 2004Publication date: August 4, 2005Applicant: Gene Logic, Inc.Inventors: Uwe Scherf, Glenn Hoke, Daniel Wilson, Debra Barnes
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Patent number: 6838256Abstract: isolated coding sequences and to the protein sequences they code for. This invention is directed to three coding sequence of the BRCA1 gene. The three coding sequences, BRCA1(omi1), BRCA1(omi2), and BRCA1(omi3) and their frequencies of occurrence are provided together with the protein sequences they code for. Another aspect of this invention is a method of determining the consensus sequence for any gene. Another aspect of the invention is a method of identifying an individual having an increased genetic susceptibility to breast or ovarian cancer because they have inherited a causative mutation in their BRCA1 gene. This invention is also related to a method of performing gene therapy with any of the isolated BRCA1 coding sequences.Type: GrantFiled: December 13, 2000Date of Patent: January 4, 2005Assignee: Gene Logic Inc.Inventors: Patricia D. Murphy, Antonette C. Allen, Christopher P. Alvares, Brenda S. Critz, Sheri J. Olson, Denise B. Schelter, Bin Zeng
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Publication number: 20040110193Abstract: Methods for classification of biological data including the use of mathematically based classification models are disclosed. In preferred embodiments, gene expression data derived from biological studies is used to classify events. The methods use a version of a linear discriminate model for deriving markers according to a technique whereby the model is limited to scoring the predictive ability of genes without making assumptions about inter-gene relationships, relative magnitudes or redundant information. In an associated method for building a fully informative database of biological information, biological studies are performed on a continual basis and linear discriminate models are used to provide rapid and efficient updates to gene markers.Type: ApplicationFiled: August 4, 2003Publication date: June 10, 2004Applicant: Gene Logic, Inc.Inventors: Arthur L. Castle, Michael R. Elashoff, Kory R. Johnson, Mark W. Porter
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Publication number: 20040048297Abstract: The present invention includes methods of normalizing quantitative and non-quantitative nucleic acid detection assays by identifying genes whose expression level is invariant among cell or tissue types. The methods of the invention can be used in the diagnosis of disease, in quality control in evaluating external data or databases, and in normalization of external data for comparative purposes. The genes of the invention can be used to produce microarrays that generate data with improved reliability.Type: ApplicationFiled: July 30, 2003Publication date: March 11, 2004Applicant: Gene Logic, Inc.Inventor: Uwe Scherf
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Publication number: 20040043405Abstract: The present invention includes methods of identifying genes whose expression level is invariant among cell or tissue types. The methods of the invention can be used in the diagnosis of disease, in quality control in evaluating external data or databases, and in normalization of external data for comparative purposes. The genes of the invention can be used to produce microarrays that generate data with improved reliability.Type: ApplicationFiled: July 17, 2003Publication date: March 4, 2004Applicant: Gene Logic, Inc.Inventors: Arthur Castle, Brandon Higgs, Michael Elashoff, Mark Porter
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Patent number: 6686163Abstract: The invention is directed to isolated coding sequences and to the protein sequences they code for. The coding sequence for BRCA1(omi4) gene is provided together with the protein sequence it codes for. The BRCA1(omi4) sequence is used for identifying an individual having an increased genetic susceptibility to breast or ovarian cancer because the patient has an inherited causative mutation in their BRCA1 gene. This invention is also related to a method of performing gene therapy with the isolated BRCA1(omi4) coding sequence and protein replacement therapy with the BRCA1(omi4) protein.Type: GrantFiled: December 20, 2001Date of Patent: February 3, 2004Assignee: Gene Logic Inc.Inventors: Antonette C. P. Allen, Tracy S. Angelly, Tammy Lawrence, Sheri J. Olson, Mark B. Rabin
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Publication number: 20030129624Abstract: New and improved methods are provided for generating amplified nucleic acid molecules from cellular mRNA. The methods are robust and reliable, and can be used to provide gene fragments for use in methods of analyzing gene expression patterns.Type: ApplicationFiled: September 17, 2002Publication date: July 10, 2003Applicant: GENE LOGIC, INC.Inventors: Eric Eastman, Glenn Hoke, John Hartwell, Larry Millstein, Michael Kuziora, Richard Guilfoyle
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Publication number: 20030082512Abstract: The present invention comprises methods of identifying an agent that modulates sterile inflammatory disease by preparing a gene expression profile of a granulocytic cell population isolated from a subject having a sterile inflammatory disease; treating it with an agent; and comparing that profile to a profile prepared from untreated granulocytic cells isolated from a subject known to have sterile inflammatory disease. The invention also includes methods to identify such agents by treating an isolated polymorphonuclear white blood cell population from a patient with a sterile inflammatory disease with an agent and comparing it to a gene expression profile of an untreated polymorponuclear white blood cell population isolated from a patient with a sterile inflammatory disease. Agents that modulate glomerulonephritis are of particular importance.Type: ApplicationFiled: December 6, 2001Publication date: May 1, 2003Applicant: GENE LOGIC, INC.Inventors: Subrahmanyam V. Yerramilli, Yatindra Prashar, Peter Newburger, Jon Goguen, Sherman M. Weissman