Abstract: Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise nucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.
Type:
Grant
Filed:
February 8, 1994
Date of Patent:
August 6, 1996
Assignee:
Gene Shears Pty. Limited
Inventors:
James P. Haseloff, Wayne L. Gerlach, Philip A. Jennings, Fiona H. Cameron
Abstract: Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise ribonucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.
Type:
Grant
Filed:
October 27, 1992
Date of Patent:
February 27, 1996
Assignee:
Gene Shears Pty. Limited
Inventors:
James P. Haseloff, Wayne L. Gerlach, Philip A. Jennings, Fiona H. Cameron
Abstract: Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise ribonucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.
Type:
Grant
Filed:
August 5, 1992
Date of Patent:
October 19, 1993
Assignee:
Gene Shears Pty. Limited
Inventors:
James P. Haseloff, Wayne L. Gerlach, Philip A. Jennings, Fiona H. Cameron
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