Abstract: Replication defective adenoviral vectors serve as vehicles for genes encoding products that kill cells in which the genes are transferred and activated. The novel vectors include tissue specific promoters, and are successful in targeting mammalian cancer cells, in particular human breast cancer cells, and causing tumors to regress.
Type:
Grant
Filed:
June 5, 1997
Date of Patent:
August 1, 2000
Assignee:
Gene Targeting Corp.
Inventors:
Sigmund Weitzman, Bayar Thimmapaya, Leonard Anderson