Abstract: A drop-in nozzle system for use with a multi-well or multi-column synthesizer or other element distribution system. The drop-in nozzle system includes one or more insertable/removable and/or disposable nozzle inserts, a nozzle housing, an input tube and a fitting. The one or more nozzle inserts are able to vary in length and have ferrule assembly positioned at the top of the insert. As a result, the system enables a user to disconnect a fitting from a nozzle housing cavity thereby releasing the system's liquid-tight seal, replace the current nozzle insert with another insert, and then reconnect the fitting recreating the liquid-tight seal and enabling the system for operation with the new nozzle insert.

Abstract: A well drain system for use with a synthesizer. The well drain system comprises a well plate, a well adapter plate and a drain plate detachably coupled together. The well plate comprises a matrix of wells for receiving one or more vials, wherein the matrix has a plurality of rows. The well adapter plate comprises an arched plate body and a plurality of apertures in communication with one or more of the wells. The drain plate comprises a plurality of channels in communication with one or more of the apertures. As a result, a user is able to selectively drain the vials found within individual rows of the well plate instead of all the vials at once.