Patents Assigned to GeneGrafts Ltd.
  • Polynucleotides and polypeptide of human KV1.3, compositions comprising same and methods of using same
    Patent number: 8101736
    Abstract: An isolated polypeptide comprising, contiguously, a first amino acid sequence being at least 90% homologous to amino acid coordinates 1-398 of SEQ ID NO: 2, a tryptophan residue and a second amino acid sequence being at least 90% homologous to amino acid coordinates 400-523 of SEQ ID NO:2. Also provided are polynucleotide sequences encoding this polypeptide and uses of same in the treatment of medical conditions associated with ion channel insufficiency.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: January 24, 2012
    Assignee: GeneGrafts Ltd.
    Inventors: Tal Bresler, Yair Feld, Reem Miari, Lior Gepstein, Shimon Marom
  • Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues
    Patent number: 8007779
    Abstract: Polynucleotide expression constructs, populations of cells and methods of treating diseases caused by dysfunction in, or damage to, excitable tissues are provided.
    Type: Grant
    Filed: January 21, 2009
    Date of Patent: August 30, 2011
    Assignee: GeneGrafts Ltd.
    Inventors: Yair Feld, Lior Gepstein, Shimon Marom
  • Polynucleotides and Polypeptide of Human KV1.3, Compositions Comprising Same and Methods of Using Same
    Publication number: 20100297083
    Abstract: An isolated polypeptide comprising, contiguously, a first amino acid sequence being at least 90% homologous to amino acid coordinates 1-398 of SEQ ID NO: 2, a tryptophan residue and a second amino acid sequence being at least 90% homologous to amino acid coordinates 400-523 of SEQ ID NO: 2. Also provided are polynucleotide sequences encoding this polypeptide and uses of same in the treatment of medical conditions associated with ion channel insufficiency.
    Type: Application
    Filed: December 12, 2006
    Publication date: November 25, 2010
    Applicant: GeneGrafts Ltd.
    Inventors: Tal Bresler, Yair Feld, Reem Miari, Lior Gepstein, Shimon Marom
  • Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues
    Publication number: 20090257990
    Abstract: Polynucleotide expression constructs, populations of cells and methods of treating diseases caused by dysfunction in, or damage to, excitable tissues are provided.
    Type: Application
    Filed: January 21, 2009
    Publication date: October 15, 2009
    Applicant: GeneGrafts Ltd.
    Inventors: Yair Feld, Lior Gepstein, Shimon Marom
  • Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues
    Patent number: 7491385
    Abstract: Polynucleotide expression constructs, populations of cells and methods of treating diseases caused by dysfunction in, or damage to, excitable tissues are provided.
    Type: Grant
    Filed: August 17, 2004
    Date of Patent: February 17, 2009
    Assignee: GeneGrafts Ltd.
    Inventors: Yair Feld, Lior Gepstein, Shimon Marom
  • Cells and methods utilizing same for modifying the electrophysiological function of excitable tissues
    Publication number: 20080112927
    Abstract: A method of treating a movement disorder in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of cells capable of modifying a neuronal discharge of the subject, thereby treating the movement disorder in the subject, wherein said administering is effected at a site selected from the group consisting of internal globus pallidus, subthalamic nucleus and substantia nigra pars reticulate.
    Type: Application
    Filed: October 22, 2007
    Publication date: May 15, 2008
    Applicant: GeneGrafts Ltd.
    Inventors: Yair Feld, Shimon Marom
  • Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues
    Patent number: 7294333
    Abstract: A method of modifying the electrophysiological function of an excitable tissue region of an individual is provided. The method includes the step of implanting cells into the excitable tissue region. Each implanted cell is (a) capable of forming gap junctions with at least one cell of the excitable tissue region; and (b) capable of forming a functional ion channel or transporter, wherein the functional ion channel or transporter is capable of modifying the electrophysiological function of the excitable tissue region.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: November 13, 2007
    Assignee: GeneGrafts Ltd.
    Inventors: Yair Feld, Lior Gepstein, Shimon Marom, Meira Frank