Patents Assigned to Genemedicine, Inc.
  • Chitosan related compositions and methods for delivery of nucleic acids and oligonucleotides into a cell
    Patent number: 6184037
    Abstract: Compositions of chitosan-based compounds and nucleic acid or oligonucleotide which are capable of delivery to a cell. Methods of preparation of the compositions. Methods of administering the compositions in vitro to cells in culture or in vivo to an organism.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: February 6, 2001
    Assignee: Genemedicine, Inc.
    Inventors: Alain Rolland, Russell J. Mumper
  • Plasmid for delivery of nucleic acids to cells and methods of use
    Patent number: 6103470
    Abstract: This invention relates to plasmid constructs useful for nonviral human gene therapy. The plasmid constructs incorporate plasmid elements for achieving high copy number, avoiding plasmid instability an providing a plasmid selection process. These constructs can be used to deliver nucleic acids to cells in vehicles which are compatible with human therapeutic use.
    Type: Grant
    Filed: December 31, 1997
    Date of Patent: August 15, 2000
    Assignee: Genemedicine, Inc.
    Inventors: Eric M. Eastman, Ross H. Durland
  • Formulated nucleic acid compositions and methods of administering the same for gene therapy
    Patent number: 6040295
    Abstract: Compositions and methods for administering nucleic acid compositions in vitro to cells in culture or in vivo to an organism whereby the uptake of nucleic acids is enhanced are provided. Various compositions, including thermo-reversible gels, are utilized to increase the viscosity of an administered nucleic acid formulation, thereby prolonging the localized bioavailability of the administered nucleic acid.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: March 21, 2000
    Assignee: Genemedicine, Inc.
    Inventors: Alain Rolland, Russell J. Mumper
  • IL-2 gene expression and delivery systems and uses
    Patent number: 6034072
    Abstract: Plasmid expression systems for delivery of DNA coding sequences to a mammal are described which provide expression of human IL-2. Also described are particular lipid/DNA delivery systems having advantageous characteristics of size, charge ratio, and proportion of supercoiled DNA, and methods of preparing and using such delivery systems for treatment.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: March 7, 2000
    Assignee: Genemedicine, Inc.
    Inventors: Robert Ralston, Susanne Muller, Russ Mumper, William Munger, Maria Bruno
  • Plasmid for delivery of nucleic acids to cells and methods of use
    Patent number: 5763270
    Abstract: This invention relates to plasmid constructs useful for nonviral human gene therapy. The plasmid constructs incorporate plasmid elements for achieving high copy number, avoiding plasmid instability an providing a plasmid selection process. These constructs can be used to deliver nucleic acids to cells in vehicles which are compatible with human therapeutic use.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 9, 1998
    Assignee: Genemedicine, Inc.
    Inventors: Eric M. Eastman, Ross H. Durland