Abstract: The present invention relates to a photochromic material comprising a proteorhodopsin apoprotein and a retinal analog. In one embodiment, the retinal analog is an azulenic retinoid compound. In another embodiment, the retinal analog is a compound that is structurally similarly to all-trans-retinal. The proteorhodopsin apoprotein and the retinal analog form a photochromic material having different spectral properties from those of a corresponding photochromic material formed by the same proteorhodopsin apoprotein and all-trans-retinal. In one embodiment of the application, the retinal analog-containing proteorhodopsin has an absorbance spectrum that does not overlap significantly with that of all-trans-retinal-containing proteorhodopsin. In another embodiment of the application, the retinal analog-containing proteorhodopsin yields a red-shifted visual chromophore compared with the all-trans-retinal-containing proteorhodopsin chromophore.
Type:
Grant
Filed:
June 9, 2005
Date of Patent:
December 29, 2009
Assignee:
Genencor International, Inc.
Inventors:
Rasmus B. Jensen, Bradley R. Kelemen, Donald E. Ward, II, Alfred E. Asato
Abstract: The invention is directed to methods of producing ethanol and decreasing residual starch production in a no cook fermentation comprising contacting granular starch containing substrates with a granular starch hydrolyzing enzyme, a protease, and a fermenting microorganism under suitable fermentation conditions at a temperature below the starch gelatinization temperature of the starch substrate to produce ethanol, wherein the ethanol production is increased and the amount of residual starch is decreased compared to a substantially similar method conducted without the protease.
Type:
Application
Filed:
June 16, 2009
Publication date:
December 24, 2009
Applicant:
GENENCOR INTERNATIONAL, INC.
Inventors:
Gang DUAN, Nigel DUNN-COLEMAN, Oreste LANTERO, Craig E. PILGRIM, Jayarama K. SHETTY
Abstract: The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and host cells including nucleic acid sequences coding for the proteases, methods for producing the proteases, enzyme compositions and methods employing said proteases.
Type:
Grant
Filed:
July 2, 2008
Date of Patent:
December 8, 2009
Assignee:
Genencor International, Inc.
Inventors:
Kathleen A. Clarkson, Nigel Dunn-Coleman, Suzanne E. Lantz, Craig E. Pilgrim, Piet Van Solingen, Michael Ward
Abstract: A composite of one or more repeat sequence protein polymers and either one or more metal oxides or one or more plasticizers alters material properties of the repeat sequence protein polymers, including the morphology of the polymers as well as the elastic modulus and tensile strength. The morphology of the composite is aligned, generally parallel nanofibers.
Abstract: The present invention relates to a method of purifying a protein of interest from its fusion analog, comprising obtaining a protein solution comprising a protein of interest and its fusion analog; adjusting the pH and/or ionic strength of the protein solution with an appropriate buffer for use with a Hydrophobic Charge Induction Chromatography (HCIC) resin, contacting the protein solution and HCIC resin column to allow binding of the protein of interest and its fusion analog, washing the resin and eluting the protein of interest from the resin by a pH gradient; wherein the protein of interest is substantially free of its fusion analog.
Abstract: The present invention provides a novel cellulase nucleic acid sequence, designated 029cel, and the corresponding 029cel amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding 029cel, recombinant 029cel proteins and methods for producing the same.
Type:
Grant
Filed:
April 28, 2004
Date of Patent:
October 20, 2009
Assignee:
Genencor International, Inc.
Inventors:
Brian E. Jones, William D. Grant, Shaun Heaphy, Susan Grant
Abstract: A novel DNA is provided which encodes an enzyme having phytase activity isolated from Trichoderma. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism, expression of the transformed DNA and the use of the expressed phytase protein in feed as a supplement.
Type:
Application
Filed:
February 17, 2009
Publication date:
October 1, 2009
Applicant:
GENENCOR INTERNATIONAL, INC.
Inventors:
Nigel Dunn-Coleman, Frits Goedegebuur, Michael Ward
Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
Type:
Application
Filed:
July 6, 2007
Publication date:
September 17, 2009
Applicant:
Genencor International, Inc.
Inventors:
Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Edmund Larenas
Abstract: Recombinant organisms are provided comprising genes encoding cob(II)alamin reductase, cob(I)alamin adenosyltransferase, glycerol dehydratase and 1,3-propanediol oxidoreductase activities useful for the production of 1,3-propanediol from a variety of carbon substrates.
Type:
Grant
Filed:
June 29, 2006
Date of Patent:
September 1, 2009
Assignees:
E.I. du Pont de Nemours and Company, Genencor International
Inventors:
Nigel S. Dunn-Coleman, Anthony Gatenby, Fernando Valle
Abstract: The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an Aspergillus strain and enzyme compositions including the same.
Type:
Application
Filed:
January 21, 2009
Publication date:
August 13, 2009
Applicant:
Genencor International, Inc.
Inventors:
Toby M. Baldwin, Kathleen A. Clarkson, Nigel Dunn-Coleman, Suzanne E. Lantz
Abstract: The present invention relates to compositions comprising high molecular weight polymers, particularly polyethylene oxide polymers, wherein the high molecular weight polymer serves as an anti-misting agent to reduce the potential of aerosol generation from a composition when used in a desired environment. The invention further relates to methods of decreasing enzyme exposure from a personal care or cleaning product comprising a high molecular weight polymer.
Type:
Grant
Filed:
July 23, 2003
Date of Patent:
July 28, 2009
Assignee:
Genencor International, Inc.
Inventors:
Nathaniel T. Becker, Herbert B. Scher, Deborah S. Winetzky
Abstract: Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated from the environment using PCR methods are described.
Type:
Grant
Filed:
March 18, 2008
Date of Patent:
July 21, 2009
Assignee:
Genencor International, Inc.
Inventors:
Mark Donnelly, William H. Eschenfeldt, Jonathan Trent
Abstract: The invention is directed to methods of producing ethanol and decreasing residual starch production in a no cook fermentation comprising contacting granular starch containing substrates with a granular starch hydrolyzing enzyme, a protease, and a fermenting microorganism under suitable fermentation conditions at a temperature below the starch gelatinization temperature of the starch substrate to produce ethanol, wherein the ethanol production is increased and the amount of residual starch is decreased compared to a substantially similar method conducted without the protease.
Type:
Grant
Filed:
December 21, 2005
Date of Patent:
July 21, 2009
Assignee:
Genencor International, Inc.
Inventors:
Gang Duan, Nigel Dunn-Coleman, Oreste Lantero, Craig E. Pilgrim, Jayarama K. Shetty
Abstract: The present invention provides means for the production of desired end-products of in vitro and/or in vivo bioconversion of biomass-based feed stock substrates, including but not limited to such materials as starch and cellulose. In particularly preferred embodiments, the methods of the present invention do not require gelatinization and/or liquefaction of the substrate.
Type:
Application
Filed:
October 2, 2008
Publication date:
July 16, 2009
Applicant:
GENENCOR INTERNATIONAL, INC.
Inventors:
Gopal K. Chotani, Manoj Kumar, Jeffrey P. Pucci, Karl J. Sanford, Jayarama K. Shetty
Abstract: The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms having exogenous nucleic acid sequences introduced therein and methods for producing proteins in such host cells, such as members of the genus Bacillus. More specifically, the present invention relates to the expression, production and secretion of a polypeptide of interest and to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention provides for the enhanced expression of a selected polypeptide by a microorganism.
Abstract: The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms having exogenous nucleic acid sequences introduced therein and methods for producing proteins in such host cells, such as members of the genus Bacillus. More specifically, the present invention relates to the expression, production and secretion of a polypeptide of interest and to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention provides for the enhanced expression of a selected polypeptide by a microorganism.
Abstract: The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms having exogenous nucleic acid sequences introduced therein and methods for producing proteins in such host cells, such as members of the genus Bacillus. More specifically, the present invention relates to the expression, production and secretion of a polypeptide of interest and to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention provides for the enhanced expression of a selected polypeptide by a microorganism.
Abstract: The present invention provides peptides and supported peptides for treating proliferative diseases. In particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold proteins is BBI.
Type:
Grant
Filed:
November 8, 2004
Date of Patent:
April 28, 2009
Assignee:
Genencor International, Inc.
Inventors:
Anthony G. Day, David A. Estell, Christopher J. Murray, Scott D. Power