Patents Assigned to Genentech, Inc.
  • PRO4405 polypeptides
    Patent number: 7125959
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 26, 2001
    Date of Patent: October 24, 2006
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Anti-Pro268 antibodies
    Patent number: 7125962
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: October 24, 2006
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Assay method
    Publication number: 20060234306
    Abstract: A new method for assaying the ability of a compound to block the binding of an ?4 integrin to a binding partner thereof provides a useful screening tool.
    Type: Application
    Filed: June 16, 2006
    Publication date: October 19, 2006
    Applicant: Genentech, Inc.
    Inventors: Dean Artis, David Jackson, Susan Keating, Maureen Beresini
  • Antibody fragment-polymer conjugates and uses of same
    Patent number: 7122636
    Abstract: Described are conjugates formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugates exhibit substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment. Also described are conjugates directed against human vascular endothelial growth factor (VEGF), human p185 receptor-like tyrosine kinase (HER2), human CD20, human CD18, human CD11a, human IgE, human apoptosis receptor-2 (Apo-2), human tumor necrosis factor-? (TNF-?), human tissue factor (TF), human ?4?7 integrin, human GPIIb-IIIa integrin, human epidermal growth factor receptor (EGFR), human CD3, and human interleukin-2 receptor ?-chain (TAC) for diagnostic and therapeutic applications.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: October 17, 2006
    Assignee: Genentech, Inc.
    Inventors: Vanessa Hsei, Iphigenia Koumenis, Steven Leong, Zahra Shahrokh, Gerardo Zapata
  • PRO274 nucleic acids
    Patent number: 7122375
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: October 17, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Margaret Ann Roy, William I. Wood
  • Polypeptide variants with altered effector function
    Patent number: 7122637
    Abstract: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: October 17, 2006
    Assignee: Genentech, Inc.
    Inventor: Leonard Presta
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7122631
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: February 2, 2005
    Date of Patent: October 17, 2006
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Lymphocyte homing receptors
    Publication number: 20060229435
    Abstract: DNA isolates coding for the lymphocyte homing receptor and methods of obtaining such DNA are provided, together with expression systems for recombinant production of the lymphocyte homing receptor useful in therapeutic or diagnostic compositions.
    Type: Application
    Filed: January 5, 2006
    Publication date: October 12, 2006
    Applicant: Genentech, Inc.
    Inventors: Laurence Lasky, Scott Stachel, Steven Rosen, Mark Singer, Ted Yednock
  • Nucleic acid overexpressed in esophageal tumor, normal stomach and melanoma
    Patent number: 7118887
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: October 10, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7119173
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: October 10, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7119177
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: October 10, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Colin K. Watanabe, William I. Wood
  • Compounds, compositions and methods for the treatment of diseases characterized by A-33 related antigens
    Patent number: 7115713
    Abstract: The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer, and nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing such antigens PRO301, PRO362 or PRO245.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: October 3, 2006
    Assignee: Genentech, Inc.
    Inventors: Avi Ashkenazi, Sherman Fong, Audrey Goddard, Austin L. Gurney, Mary A. Napier, Daniel Tumas, William I. Wood
  • PRO9821 nucleic acids
    Patent number: 7115415
    Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 16, 2002
    Date of Patent: October 3, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Jean-Philippe F. Stephan, Colin K. Watanabe, William I. Wood
  • DNA 19355 polypeptide, a tumor necrosis factor homolog
    Publication number: 20060216270
    Abstract: A tumor necrosis factor homolog, identified as DNA19355, is provided. DNA19355 polypeptide has apoptotic activity in mammalian cancer cells and may be involved in proinflammatory responses. Nucleic acid molecules encoding DNA19355, chimeric molecules and antibodies to DNA19355 are also provided.
    Type: Application
    Filed: February 14, 2006
    Publication date: September 28, 2006
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Kevin Baker, Paul Godowski, Austin Gurney, Melanie Mark, Scot Marsters, Robert Pitti
  • Transgenic mice expressing human cd20 and/or cd16
    Publication number: 20060218655
    Abstract: The present invention generally relates to non-human transgenic animals expressing human cellular markers, including CD20 and/or preferably CD16.
    Type: Application
    Filed: December 11, 2003
    Publication date: September 28, 2006
    Applicant: Genentech, Inc.
    Inventors: Andrew Chan, Qian Gong, Flavius Martin
  • Compositions with hematopoietic and immune activity
    Publication number: 20060217301
    Abstract: The present invention provides methods of using Bv8 and EG-VEGF polypeptides and nucleic acids to promote hemtopoiesis. Also provided herein are methods of screening for modulators of Bv8 and EG-VEGF activity. Furthermore, methods of treatment using Bv8 and EG-VEGF polypeptides or Bv8 and EG-VEGF antagonists are provided.
    Type: Application
    Filed: March 12, 2004
    Publication date: September 28, 2006
    Applicant: GENENTECH, INC.
    Inventors: Napoleone Ferrara, Jennifer Lecouter
  • PRO1312 polypeptides
    Patent number: 7112656
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: September 26, 2006
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • PRO697 polypeptides
    Patent number: 7112657
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: September 26, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, William I. Wood
  • Novel composition and methods for the treatment of immune disorders
    Publication number: 20060210556
    Abstract: The present invention relates to compositions of matter and methods for the treatment and diagnosis of immune related diseases, including those mediated by cytokines released primarily either Th1 or Th2 cells in response to antigenic stimulation. The present invention further relates to methods for biasing the differentiation of T-cells in either the Th1 subtype or the Th2 subtype based on the relative expression levels of the gene PRO92726, and its agonists or antagonists. The present invention further relates to a method of diagnosing Th1- and Th2-mediated diseases.
    Type: Application
    Filed: April 8, 2004
    Publication date: September 21, 2006
    Applicant: Genentech, Inc.
    Inventors: Daryl Baldwin, Hilary Clark, Henry Chiu, Grazyna Fedorowicz, Sherman Fong, J. Grimaldi, Wenjun Quyang, P. Williams
  • Halo-alkoxycarbonyl prodrugs
    Patent number: 7109326
    Abstract: Halo-alkoxycarbonyl derivatives are provided as prodrug moieties for pharmaceutical agents containing a basic or polar nitrogen containing functionality. The prodrugs are provided as pharmaceutical compositions as well as in methods of treatment.
    Type: Grant
    Filed: May 25, 2004
    Date of Patent: September 19, 2006
    Assignee: Genentech, Inc.
    Inventors: Brent Blackburn, Alan G. Olivero, Kirk Robarge