Patents Assigned to Genentech
  • COMBINATION THERAPIES
    Publication number: 20140093568
    Abstract: The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention relates to therapies for the treatment of pathological conditions, such as cancer.
    Type: Application
    Filed: August 15, 2013
    Publication date: April 3, 2014
    Applicant: Genentech, Inc.
    Inventors: Gordon Bray, Iris Chan
  • Phage display
    Patent number: 8685893
    Abstract: The transformation yield of electroporation is increased by using higher DNA concentrations and DNA affinity purification. Fusion proteins of a viral coat protein variant and a heterologous polypeptide are useful in phage display systems.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: April 1, 2014
    Assignee: Genentech, Inc.
    Inventors: Sachdev S. Sidhu, Gregory A. Weiss, James A. Wells
  • HERCEPTIN® ADJUVANT THERAPY
    Publication number: 20140086940
    Abstract: The present application describes adjuvant therapy of nonmetastatic breast cancer using HERCEPTIN®.
    Type: Application
    Filed: October 25, 2013
    Publication date: March 27, 2014
    Applicant: Genentech, Inc.
    Inventor: John L. Bryant
  • SUBSTITUTED 6,6-FUSED NITROGENOUS HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20140088076
    Abstract: The invention provides novel compounds having the general formula: wherein X1 is N or N+O?, and one of X2, X3 and X4 is N or N+—O? and the remainder of X2, X3 and X4 is C. R2, R3, R4, R5, R6. A, B and Y are as described herein. Additionally compositions compounds of Formula I and methods of use are further described herein.
    Type: Application
    Filed: October 31, 2013
    Publication date: March 27, 2014
    Applicant: Genentech, Inc.
    Inventors: Joseph P. Lyssikatos, Lewis J. Gazzard, Emily Hanan, Samuel S. Kintz, Hans Edward Purkey
  • METHODS AND COMPOSITIONS FOR PRODUCING INDUCED HEPATOCYTES
    Publication number: 20140087416
    Abstract: The present invention relates to methods and compositions for use in generating induced hepatocytes by reprogramming non-hepatocyte cells.
    Type: Application
    Filed: September 6, 2013
    Publication date: March 27, 2014
    Applicant: Genentech, Inc.
    Inventors: Kamen P. Simeonov, Hirdesh Uppal
  • CYCLIC ETHER PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE
    Publication number: 20140088117
    Abstract: Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R2 is a cyclic ether and X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
    Type: Application
    Filed: September 25, 2013
    Publication date: March 27, 2014
    Applicant: Genentech, Inc.
    Inventors: Jason Burch, Minghua Sun, Xiaojing Wang, Wesley Blackaby, Alastair James Hodges, Andrew Sharpe
  • METHOD FOR TREATING INTRAOCULAR NEOVASCULAR DISEASES
    Publication number: 20140086934
    Abstract: A method is provided for administering to a mammal suffering from, or at risk for, an intraocular neovascular disorder with regular dosing of a therapeutically effective amount of VEGF antagonist, followed by less frequent dosing of a therapeutically effective amount of VEGF antagonist.
    Type: Application
    Filed: February 28, 2013
    Publication date: March 27, 2014
    Applicant: GENENTECH, INC.
    Inventor: Genentech, Inc.
  • AKT protein kinase inhibitors
    Patent number: 8680114
    Abstract: The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: March 25, 2014
    Assignees: Array Biopharma, Inc., Genentech, Inc.
    Inventors: Ian S. Mitchell, Keith L. Spencer, Peter Stengel, Yongxin Han, Nicholas C. Kallan, Mark Munson, Guy P. A. Vigers, James Blake, Anthony Piscopio, John Josey, Scott Miller, Dengming Xiao, Rui Xu, Chang Rao, Bing Wang, April L. Bernacki
  • Genetic variations associated with tumors
    Patent number: 8680041
    Abstract: Nucleotide and amino acid variations associated with tumors are provided. Methods for detecting variations and for diagnosing and treating tumors are provided.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: March 25, 2014
    Assignee: Genentech, Inc.
    Inventors: Zhengyan Kan, Denise M. Kenski, Brock Peters, Somasekar Seshagiri
  • Binding polypeptides with diversified and consensus VH/VL hypervariable sequences
    Patent number: 8679490
    Abstract: The invention provides variant hypervariable regions comprising selected amino acid sequence diversity. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.
    Type: Grant
    Filed: November 7, 2006
    Date of Patent: March 25, 2014
    Assignee: Genentech, Inc.
    Inventors: Mark S. Dennis, Wei-Ching Liang, Yan Wu
  • Multiple reaction monitoring LC-MS/MS method to detect therapeutic antibodies in animal samples using framework signature peptides
    Patent number: 8679767
    Abstract: Methods are disclosed to detect, characterize, measure, and quantitate human and humanized antibodies, and their conjugates, present in pre-clinical animal biological samples, including plasma/serum and tissue samples.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: March 25, 2014
    Assignee: Genentech, Inc.
    Inventors: Surinder Kaur, Ola Saad, Keyang Xu
  • Knobs and holes heteromeric polypeptides
    Patent number: 8679785
    Abstract: The invention relates to a method of preparing heteromultimeric polypeptides such as bispecific antibodies, bispecific immunoadhesins, heteromultimers and antibody-immunoadhesin chimeras. Generally, the method involves introducing a protuberance at the interface of a first polypeptide and a corresponding cavity in the interface of a second polypeptide, such that the protuberance can be positioned in the cavity so as to promote heteromultimer formation and hinder homomultimer formation. The protuberance and cavity can be made by synthetic means such as altering the nucleic acid encoding the polypeptides or by peptide synthesis.
    Type: Grant
    Filed: June 12, 2012
    Date of Patent: March 25, 2014
    Assignee: Genentech, Inc.
    Inventors: Paul J. Carter, Leonard G. Presta, John B. Ridgway
  • HARVEST OPERATIONS FOR RECOMBINANT PROTEINS
    Publication number: 20140080180
    Abstract: The present invention contemplates methods of producing a recombinant protein comprising fermenting a prokaryotic host cell wherein said prokaryotic host cell has been transformed with a nucleic acid encoding said recombinant protein, harvesting said recombinant protein under conditions where dO2 levels are greater than 0%, purifying said recombinant protein to a filtered bulk, wherein said filtered bulk does not contain detectable DHNA-recombinant protein adduct, as measured by an IEC assay at 310 nm.
    Type: Application
    Filed: March 14, 2013
    Publication date: March 20, 2014
    Applicant: GENENTECH, INC.
    Inventor: Genentech, Inc.
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
    Publication number: 20140080152
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: August 9, 2013
    Publication date: March 20, 2014
    Applicant: Genentech, Inc.
    Inventors: Mark Dennis, Bonnee Rubinfeld, Paul Polakis
  • METHODS AND COMPOSITIONS FOR PREVENTING NORLEUCINE MISINCORPORATION INTO PROTEINS
    Publication number: 20140081003
    Abstract: The present invention relates to methods and compositions for preventing incorporation of norleucine into proteins during recombinant protein production in bacteria. The present invention also provides microorganism host cells and nucleic acid molecules for use with the methods and compositions provided herein.
    Type: Application
    Filed: September 19, 2013
    Publication date: March 20, 2014
    Applicant: Genentech, Inc.
    Inventors: Michael W. Laird, Karthik Veeravalli
  • PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE
    Publication number: 20140080801
    Abstract: Pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
    Type: Application
    Filed: November 18, 2013
    Publication date: March 20, 2014
    Applicant: Genentech, Inc.
    Inventors: Alastair James Hodges, Mizio Matteucci, Andrew Sharpe, Minghua Sun, Xiaojing Wang, Vickie H. Tsui
  • PYRROLIDINE INHIBITORS OF IAP
    Publication number: 20140080805
    Abstract: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, Q, X1, X2, Y, R1, R2, R3, R4, R4?, R5, R6 and R6? are as described herein.
    Type: Application
    Filed: November 22, 2013
    Publication date: March 20, 2014
    Applicant: Genentech, Inc.
    Inventors: Frederick COHEN, Vickie Hsiao-Wei TSUI, Cuong LY, John A. FLYGARE
  • DOSAGES FOR TREATMENT WITH ANTI-EGFR ANTIBODIES
    Publication number: 20140079692
    Abstract: The present invention concerns dosages for treatment of human cancer patients with an anti-Epidermal Growth Factor Receptor (EGFR) antibody.
    Type: Application
    Filed: November 6, 2013
    Publication date: March 20, 2014
    Applicant: Genentech, Inc.
    Inventors: Sharon A. Baughman, Steven Shak
  • PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
    Publication number: 20140080829
    Abstract: The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
    Type: Application
    Filed: November 21, 2013
    Publication date: March 20, 2014
    Applicants: Genentech, Inc., Array BioPharma Inc.
    Inventors: Josef Bencsik, James F. Blake, James M. Graham, Martin F. Hentemann, Nicholas C. Kallan, Ian S. Mitchell, Stephen T. Schlachter, Keith L. Spencer, Dengming Xiao, Rui Xu, Mike Welch, Jun Liang, Brian S. Safina
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
    Publication number: 20140079721
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: August 9, 2013
    Publication date: March 20, 2014
    Applicant: Genentech, Inc.
    Inventors: Mark Dennis, Bonnee Rubinfeld, Paul Polakis