Patents Assigned to Genentech
  • AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS
    Publication number: 20130157999
    Abstract: Specific Compounds of formula I: or pharmaceutically acceptable salts thereof, wherein m, X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
    Type: Application
    Filed: November 28, 2012
    Publication date: June 20, 2013
    Applicant: GENENTECH, INC.
    Inventor: Genentech, Inc.
  • IMMUNO-PET IMAGING OF ANTIBODIES AND IMMUNOCONJUGATES AND USES THEREFOR
    Publication number: 20130157289
    Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
    Type: Application
    Filed: December 3, 2012
    Publication date: June 20, 2013
    Applicant: GENENTECH, INC.
    Inventor: Genentech, Inc.
  • AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS
    Publication number: 20130158032
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
    Type: Application
    Filed: November 28, 2012
    Publication date: June 20, 2013
    Applicant: Genentech, Inc.
    Inventor: Genentech, Inc.
  • AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS
    Publication number: 20130158057
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
    Type: Application
    Filed: November 28, 2012
    Publication date: June 20, 2013
    Applicant: GENENTECH, INC.
    Inventor: Genentech, Inc.
  • FLUORINE-18 AND CARBON-11 LABELED RADIOLIGANDS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR LRRK2
    Publication number: 20130156700
    Abstract: A method for positron emission tomography (PET) imaging of LRRK2 in tissue of a subject, the method comprising: administering a compound of formula I, formula II or formula III, or a pharmaceutically acceptable salt thereof to the subject, wherein the compound includes at least one C11 or F18 label thereon; allowing the compound to penetrate into the tissue of the subject; and collecting a PET image of the CNS or brain tissue of the subject
    Type: Application
    Filed: November 28, 2012
    Publication date: June 20, 2013
    Applicant: GENENTECH, INC.
    Inventor: Genentech, Inc.
  • AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS
    Publication number: 20130158006
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein A, X, R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
    Type: Application
    Filed: November 28, 2012
    Publication date: June 20, 2013
    Applicant: GENENTECH, INC.
    Inventor: Genentech, Inc.
  • Anti-FcRH5 antibodies and immunoconjugates and methods of use
    Patent number: 8466260
    Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: June 18, 2013
    Assignee: Genentech, Inc.
    Inventors: Kristi Elkins, Andrew Polson, Allen Ebens, Camelia Adams, Bing Zheng, Jagath R. Junutula, Jo-Anne Hongo, Yan Wu
  • Crystal structures of neuropilin fragments and neuropilin-antibody complexes
    Patent number: 8466264
    Abstract: The invention provides crystal structures of neuropilin 1 (Nrp1) and neuropilin 2 (Nrp2) fragments alone and in complex with anti-neuropilin antibodies, and method for their use. The invention further provides anti-Nrp antibodies and methods for their therapeutic applications.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: June 18, 2013
    Assignee: Genentech, Inc.
    Inventors: Brent A. Appleton, Christian Wiesmann, Yan Wu
  • DELIVERY SYSTEM FOR DIAGNOSTIC AND THERAPEUTIC AGENTS
    Publication number: 20130149237
    Abstract: The invention provides shuttle agents and methods of using the same to facilitate the translocation of therapeutic or diagnostic molecules into the CNS.
    Type: Application
    Filed: January 21, 2011
    Publication date: June 13, 2013
    Applicants: GENENTECH, INC., F. HOFFMANN-LA ROCHE AG
    Inventors: Mark Dennis, Per-Ola Freskgard, Stephen Tam, Ryan Watts, Joy Yu
  • ANTIBODIES TO IL-1BETA AND IL-18, FOR TREATMENT OF DISEASE
    Publication number: 20130149308
    Abstract: The present invention relates to compositions and methods for treatment of disease. More particularly, the present invention relates to anti-IL-1? and anti-IL-18 antibodies, including anti-IL-1? and anti-IL-18 bispecific antibodies, and methods of treating disease using such antibodies.
    Type: Application
    Filed: February 11, 2013
    Publication date: June 13, 2013
    Applicant: GENENTECH, INC.
    Inventor: Genentech, Inc.
  • 5-ANILINOIMIDAZOPYRIDINES AND METHODS OF USE
    Publication number: 20130150584
    Abstract: The invention relates to a method of inhibiting abnormal cell growth or treating a hyperproliferative disorder in a mammal comprising administering to said mammal a therapeutically effective amount of an imidazopyridine of formula I with anti-hyperproliferative activity.
    Type: Application
    Filed: February 5, 2013
    Publication date: June 13, 2013
    Applicant: GENENTECH, INC.
    Inventor: Genentech, Inc.
  • HUMANIZED ANTI-EGFL7 ANTIBODIES AND METHODS USING SAME
    Publication number: 20130149307
    Abstract: The present invention concerns antibodies to EGFL7 and the uses of same.
    Type: Application
    Filed: November 2, 2012
    Publication date: June 13, 2013
    Applicant: Genentech, Inc.
    Inventor: Genentech, Inc.
  • Tricyclic heterocyclic compounds, compositions and methods of use thereof
    Patent number: 8461328
    Abstract: The invention provides novel compounds of formula I having the general formula: wherein R1, R2, R3, X and Y are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: June 11, 2013
    Assignee: Genentech, Inc.
    Inventors: Srinivasan Babu, Phillippe Bergeron, Peter Dragovich, Hazel Joan Dyke, Paul Gibbons, Stefan Gradl, Emily Hanan, Christopher Hurley, Tony Johnson, Michael Koehler, Janusz Kulagowski, Sharada Labadie, Joseph Lyssikatos, Rohan Mendonca, Rebecca Pulk, Stuart Ward, Bohdan Waszkowycz, Mark Zak
  • ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES
    Publication number: 20130144040
    Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
    Type: Application
    Filed: November 5, 2012
    Publication date: June 6, 2013
    Applicant: GENENTECH, INC.
    Inventor: Genentech, Inc.
  • PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
    Publication number: 20130143865
    Abstract: The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
    Type: Application
    Filed: January 29, 2013
    Publication date: June 6, 2013
    Applicants: GENENTECH, INC., ARRAY BIOPHARMA INC.
    Inventors: Array BioPharma Inc., GENENTECH, INC.
  • COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS
    Publication number: 20130143824
    Abstract: The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: October 17, 2012
    Publication date: June 6, 2013
    Applicant: Genentech, Inc.
    Inventor: Genentech, Inc.
  • COMPOSITIONS AND METHODS FOR PROSTATE CANCER ANALYSIS
    Publication number: 20130143237
    Abstract: The invention provides methods for diagnosing prostate cancer. The invention also provides novel anti-STEAP-1 antibodies and uses thereof.
    Type: Application
    Filed: November 29, 2012
    Publication date: June 6, 2013
    Applicant: GENENTECH, INC.
    Inventor: Genentech, Inc.
  • METHODS AND COMPOSITIONS FOR MODULATING HGF/MET
    Publication number: 20130143813
    Abstract: The invention provides methods and compositions for modulating the HGF/c-met signaling pathway, in particular by regulating binding of HGF ? chain to c-met.
    Type: Application
    Filed: December 7, 2011
    Publication date: June 6, 2013
    Applicant: Genentech, Inc.
    Inventors: Daniel K. Kirchhofer, Robert A. Lazarus, Xiaoyi Yao
  • FIXED DOSING OF HER ANTIBODIES
    Publication number: 20130142865
    Abstract: The present invention concerns fixed dosing of HER antibodies, such as Pertuzumab.
    Type: Application
    Filed: January 18, 2013
    Publication date: June 6, 2013
    Applicant: GENENTECH, INC.
    Inventor: Genentech, Inc.
  • Nucleic acids encoding IL-17 homologous receptor-like polypeptides and therapeutic uses thereof
    Patent number: 8455217
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: June 4, 2013
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, William I. Wood