Patents Assigned to Genentech
  • PRO7436 polypeptides
    Patent number: 7335730
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: February 26, 2008
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • PRO4320 polypeptide
    Patent number: 7335729
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: February 26, 2008
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • PRO1310 polypeptides
    Patent number: 7335728
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: April 16, 2002
    Date of Patent: February 26, 2008
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • PRO9799 polypeptides
    Patent number: 7335732
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: February 26, 2008
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • Polypeptide variants with altered effector function
    Patent number: 7335742
    Abstract: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
    Type: Grant
    Filed: May 8, 2006
    Date of Patent: February 26, 2008
    Assignee: Genentech, Inc.
    Inventor: Leonard Presta
  • PRO4332 polypeptides
    Patent number: 7335731
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: February 26, 2008
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • Methods of using death receptor ligands and CD20 antibodies
    Publication number: 20080044421
    Abstract: Methods for using death receptor ligands, such as Apo-2 ligand/TRAIL polypeptides or death receptor antibodies, and CD20 antibodies to treat conditions such as cancer and immune related diseases are provided. Embodiments of the invention include methods of using Apo2L/TRAIL or death receptor antibodies such as DR5 antibodies and DR4 antibodies in combination with CD20 antibodies.
    Type: Application
    Filed: October 3, 2006
    Publication date: February 21, 2008
    Applicant: Genentech, Inc.
    Inventor: Avi Ashkenazi
  • Polypeptide variants with altered effector function
    Patent number: 7332581
    Abstract: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: February 19, 2008
    Assignee: Genentech, Inc.
    Inventor: Leonard Presta
  • PRO19628 Antibodies
    Patent number: 7332583
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: February 19, 2008
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, Colin K. Watanabe, William I. Wood
  • PRO1571 polypeptides
    Patent number: 7332573
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: February 19, 2008
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • Anti-pro4407 antibodies
    Patent number: 7332578
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: September 11, 2002
    Date of Patent: February 19, 2008
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Austin L. Gurney, Victoria Smith, Colin K. Watanabe, William I. Wood
  • Antibodies to human ErbB4
    Patent number: 7332579
    Abstract: The present invention concerns isolated antibodies that specifically bind to the human ErbB4 of SEQ ID NO:2, as well as humanized antibodies, human antibodies and antibody fragments, as well as bispecific antibodies capable of binding both the human ErbB4 of SEQ ID NO:2 and ErbB3. The invention further concerns antibodies which specifically bind to human ErbB4 of SEQ ID NO: 2 with a Kd less than 100 nM, antibodies which specifically bind to human ErbB4 of SEQ ID NO: 2 and which reduces heregulin binding thereto, and antibodies which specifically bind to human ErbB4 of SEQ ID NO: 2 and which reduce heregulin-induced tyrosine phosphorylation thereof.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: February 19, 2008
    Assignee: Genentech, Inc.
    Inventors: Mary E. Gerritsen, Mark X. Sliwkowski
  • Phosphoinositide 3-kinase inhibitor compounds and methods of use
    Publication number: 20080039459
    Abstract: Compounds of Formulas Ia and Ib, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
    Type: Application
    Filed: April 24, 2007
    Publication date: February 14, 2008
    Applicants: Plramed Limited, Genentech, Inc.
    Inventors: Adrian Folkes, Stephen Shuttleworth, Sally Oxenford, Tim Hancox, Tracy Bayliss, Georgette Castanedo, Richard Goldsmith, Janet Gunzner, Tim Heffron, Kimberly Malesky, Simon Mathieu, Alan Olivero, Daniel Sutherlin, Vickie Tsui, Shumei Wang, Christian Wiesmann, Bing-Yan Zhu, Jennafer Dotson
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
    Publication number: 20080038264
    Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: September 29, 2006
    Publication date: February 14, 2008
    Applicant: Genentech, Inc.
    Inventors: Sarah Bodary, Hilary Clark, Brisdell Hunte, Janet Jackman, Jill Schoenfeld, P. Williams, William Wood, Thomas Wu
  • ENRICHMENT METHOD FOR VARIANT PROTEINS WITH ALTERED BINDING PROPERTIES
    Publication number: 20080038717
    Abstract: A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants.
    Type: Application
    Filed: June 11, 2007
    Publication date: February 14, 2008
    Applicant: Genentech, Inc.
    Inventors: Lisa Garrard, Dennis Henner, Steven Bass, Ronald Greene, Henry Lowman, James Wells, David Matthews
  • PRO4348 polypeptides
    Patent number: 7329730
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: February 12, 2008
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • Antibodies against PRO1310
    Patent number: 7329404
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: April 16, 2002
    Date of Patent: February 12, 2008
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • TREATMENT METHOD
    Publication number: 20080031875
    Abstract: The present invention relates to a method for the treating an LFA-1 mediated disorder or a TNF-? mediated disorder by administering effective amounts of an LFA-1 antagonist and a TNF-? antagonist.
    Type: Application
    Filed: July 26, 2007
    Publication date: February 7, 2008
    Applicant: Genentech, Inc.
    Inventors: Wyne Lee, Daniel Tumas
  • Use of ErbB receptor ligands in treating diabetes
    Publication number: 20080031880
    Abstract: The invention provides methods for treating pancreatic dysfunction, particularly diabetes, in mammals using ErbB receptor ligands, such as heregulin, betacellulin, and EGF. Methods of treating such conditions using anti-ErbB receptor agonist antibodies are further provided. The methods of the invention may be performed by direct administration of such therapeutically useful agents to mammals, or alternatively, by exposing certain pancreatic cell types to such agents in vitro and subsequently transplanting the treated cells to a mammal.
    Type: Application
    Filed: August 7, 2007
    Publication date: February 7, 2008
    Applicant: Genentech, Inc.
    Inventors: Xiaojian Huang, Timothy Stewart
  • Recombinant Production of Heparin Binding Proteins
    Publication number: 20080032343
    Abstract: A process for recovering and purifying refolded heparin binding proteins produced in heterologous host cells includes the step of incubation of the solubilized protein with a polyanionic species such as dextran sulfate.
    Type: Application
    Filed: December 19, 2006
    Publication date: February 7, 2008
    Applicant: Genentech, Inc.
    Inventors: Michelle Butler, Jeffrey Cleland, David Kahn, Shelly Pizarro, Charles Schmelzer, Marjorie Winkler