Patents Assigned to Genentech
  • PRO1184 polypeptides
    Patent number: 6930170
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: August 16, 2005
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 6929947
    Abstract: The present invention is directed to nucleic acids encoding a secreted polypeptide that inhibits neoplastic growth in tumor cells. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: August 16, 2005
    Assignee: Genentech, Inc.
    Inventors: David Botstein, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Margaret Ann Roy, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 6930172
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 27, 2001
    Date of Patent: August 16, 2005
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, Wei-Qiang Gao, Audrey Goddard, Austin L. Gurney, Colin K. Watanabe, William I. Wood
  • Compositions and methods for the diagnosis and treatment of tumors
    Publication number: 20050176046
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: January 28, 2005
    Publication date: August 11, 2005
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Dan Eaton, Audrey Goddard, Austin Gurney, William Wood, Thomas Wu
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050176041
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 30, 2004
    Publication date: August 11, 2005
    Applicant: GENENTECH, INC.
    Inventors: Victoria Smith, Colin Watanabe
  • Treatment of inner ear hair cells
    Patent number: 6927204
    Abstract: Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: August 9, 2005
    Assignee: Genentech, Inc.
    Inventor: Wei-Qiang Gao
  • Tangential-flow filtration system
    Patent number: 6926833
    Abstract: The present invention includes a system and method for transferring a selected solute species from a fluid mixture to a fluid media. The system of the present invention includes a convergent channel for passing a fluid mixture containing a selected species tangentially across the first surface of a porous membrane. A fluid media is directed to flow tangentially over the second surface of the membrane. As the fluid mixture and the fluid media flow on opposite sides of the membrane, the selected species traverses the membrane leaving the fluid mixture and entering the fluid media. The volumetric loss to the fluid mixture associated with the loss of the selected species is compensated for by the convergency of the channel. As a result a constant velocity is maintained over the membrane, maximizing the selectivity of the filtration process.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: August 9, 2005
    Assignee: Genentech, Inc.
    Inventor: Robert D. van Reis
  • PCR assay
    Patent number: 6927024
    Abstract: An oligonucleotide assay is useful for the detection of target compounds in samples which may contain the target compound.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: August 9, 2005
    Assignee: Genentech, Inc.
    Inventors: Anthony H. Dodge, Yu-Ju G. Meng, Paul W. Sims, Dominick V. Sinicropi, P. Mickey Williams, Wai Lee Wong
  • Prokaryotically produced antibodies and use thereof
    Publication number: 20050170464
    Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.
    Type: Application
    Filed: March 2, 2005
    Publication date: August 4, 2005
    Applicant: GENENTECH, INC.
    Inventors: Laura Simmons, Laura Klimowski, Dorothea Reilly, Daniel Yansura
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050170458
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: February 2, 2005
    Publication date: August 4, 2005
    Applicant: GENENTECH, INC.
    Inventors: Napoleone Ferrara, Audrey Goddard, Paul Godowski, Austin Gurney, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050170465
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: March 15, 2005
    Publication date: August 4, 2005
    Applicant: GENENTECH, INC.
    Inventors: Napoleone Ferrara, Audrey Goddard, Paul Godowski, Austin Gurney, Kenneth Hillan, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050170467
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: February 2, 2005
    Publication date: August 4, 2005
    Applicant: GENENTECH, INC.
    Inventors: Napoleone Ferrara, Audrey Goddard, Paul Godowski, Austin Gurney, William Wood
  • Treatment and diagnosis of insulin-resistant states
    Publication number: 20050170440
    Abstract: Dickkopf-5 (Dkk-5) protein is administered in effective amounts to treat disorders involving insulin resistance, such as non-insulin-dependent diabetes mellitus (NIDDM) or obesity. Also provided is a method of diagnosing insulin resistance and related disorders using Dkk-5 as a measure, and kits for diagnosis and treatment, as well as hybridomas producing antibodies to Dkk-5 and preparations comprising Dkk-5.
    Type: Application
    Filed: February 11, 2005
    Publication date: August 4, 2005
    Applicant: Genentech, Inc.
    Inventors: Venita DeAlmeida, Timothy Stewart
  • Compositions and methods for the diagnosis and treatment of tumor
    Publication number: 20050170368
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: July 2, 2004
    Publication date: August 4, 2005
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Belinda Caims, Patrick Dowd, Gretchen Frantz, Dorothy French, Lino Gonzalez, Paul Polakis, Victoria Smith, Beni Wolf, Thomas Wu, Zemin Zhang
  • PRO1343 polypeptides
    Patent number: 6924355
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: August 2, 2005
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Compositions and methods for the diagnosis and treatment of tumor
    Publication number: 20050164250
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: November 19, 2004
    Publication date: July 28, 2005
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Audrey Goddard, Austin Gurney, Paul Polakis, Victoria Smith, William Wood, Thomas Wu, Dong-Xiao Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050164266
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: January 13, 2005
    Publication date: July 28, 2005
    Applicant: Genentech, Inc.
    Inventors: Victoria Smith, Colin Watanabe
  • Compaction assay for assessment of respiratory disease therapy
    Publication number: 20050164334
    Abstract: A compaction assay measuring the viscoelasticity of sputum samples of patients subject to respiratory disease is provided. This assay is useful in determining the therapeutic efficacy of DNase, antibiotic and other respiratory disease treatments in improving lung function.
    Type: Application
    Filed: January 10, 2005
    Publication date: July 28, 2005
    Applicant: Genentech, Inc.
    Inventors: Ann Daugherty, Randy Mrsny, Thomas Patapoff
  • Combination therapy for B cell disorders
    Publication number: 20050163775
    Abstract: The invention provides methods of treating B cell based malignancies and B-cell regulated autoimmune disorders using a combination therapy of anti-CD20 antibody with a BAFF antagonist.
    Type: Application
    Filed: December 22, 2004
    Publication date: July 28, 2005
    Applicant: Genentech, Inc.
    Inventors: Andrew Chan, Qian Gong, Flavius Martin
  • Secreted and transmembrane polypetides and nucleic acids encoding the same
    Publication number: 20050164279
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: February 16, 2005
    Publication date: July 28, 2005
    Applicant: GENENTECH, INC.
    Inventors: Kevin Baker, Audrey Goddard, Paul Godowski, Austin Gurney, Victoria Smith, William Wood