Patents Assigned to Genentech
  • Pyridopyrimidinones and methods of use thereof
    Patent number: 10280165
    Abstract: The invention relates to pyridopyrimidinone compounds of formula I or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5 and R6 are as defined herein, as well as pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: May 7, 2019
    Assignee: Genentech, Inc.
    Inventors: Matthew Volgraf, Yu Jiang, Elisia Villemure, Benjamin Sellers, Guosheng Wu, Aijun Lu
  • COMPOSITIONS AND METHODS FOR REGULATING CELL OSMOLARITY
    Publication number: 20190127741
    Abstract: The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing an osmo-responsive transcriptional regulatory element (OR-TRE).
    Type: Application
    Filed: September 26, 2018
    Publication date: May 2, 2019
    Applicant: Genentech, Inc.
    Inventors: Laetitia MALPHETTES, Andrew Snowden, Inn H. Yuk
  • BICYCLIC SULFONES AND SULFOXIDES AND METHODS OF USE THEREOF
    Publication number: 20190127382
    Abstract: The invention provides novel compounds having the general formula I: wherein R1, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
    Type: Application
    Filed: October 30, 2018
    Publication date: May 2, 2019
    Applicant: Genentech, Inc.
    Inventors: Snahel Patel, Gregory Hamilton, Craig Stivala, Huifen Chen, Blake Daniels
  • Elucidation of ion exchange chromatography input optimization
    Patent number: 10274466
    Abstract: The present invention provides methods for determining chromatography separation conditions; for example, separation of a polypeptide and its charge variants. The invention also provides methods to determine a buffer condition for chromatography separation conditions. The invention also provides a robust method to analyze multiple polypeptide products.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: April 30, 2019
    Assignee: GENENTECH, INC.
    Inventors: Daniel McDonald, Thomas Patapoff, Yajun Wang
  • Methods for diagnosing and treating inflammatory bowel disease
    Patent number: 10273542
    Abstract: Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: April 30, 2019
    Assignee: GENENTECH, INC.
    Inventors: Jason A. Hackney, Mary Keir, Gaik Wei Tew
  • Compounds and compositions for the inhibition of NAMPT
    Patent number: 10272072
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: April 30, 2019
    Assignees: Forma TM, LLC, Genentech, Inc.
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre Joseph Buckmelter, Karl H. Clodfelter, Peter Dragovich, Francis Gosselin, Bingsong Han, Jian Lin, Dominic J. Reynolds, Bruce Roth, Chase C. Smith, Zhongguo Wang, Po-Wai Yuen, Xiaozhang Zheng
  • USES FOR AND ARTICLE OF MANUFACTURE INCLUDING HER2 DIMERIZATION INHIBITOR PERTUZUMAB
    Publication number: 20190117769
    Abstract: The present application describes uses for Pertuzumab, a first-in-class HER2 dimerization inhibitor. In particular, the application describes methods for extending progression free survival in a HER2-positive breast cancer patient population; and combining two HER2 antibodies to treat HER2-positive cancer without increasing cardiac toxicity.
    Type: Application
    Filed: September 6, 2018
    Publication date: April 25, 2019
    Applicant: Genentech, Inc.
    Inventors: Mark C. Benyunes, Emma L. Clark, Lada Mitchell, Christina H. de Toledo Pelizon, Jayantha Ratnayake, Graham A. Ross
  • 2-AZABICYCLO[3.1.0]HEXAN-3-ONE DERIVATIVES AND METHODS OF USE
    Publication number: 20190119274
    Abstract: The invention relates to compounds of formula (I): wherein Q, A1, A2, A3, A5, A6, A7, A8, R4a, R4b and R5 are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
    Type: Application
    Filed: December 14, 2018
    Publication date: April 25, 2019
    Applicant: Genentech, Inc.
    Inventors: James John Crawford, Aleksandr Kolesnikov, Jianwen A. Feng
  • 2-AZABICYCLO[3.1.0]HEXAN-3-ONE DERIVATIVES AND METHODS OF USE
    Publication number: 20190119246
    Abstract: The invention relates to compounds of formula (I): wherein A1, A2, A3, A4, A5, A6, A7, A8, R4a, R4b and R5 are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
    Type: Application
    Filed: December 14, 2018
    Publication date: April 25, 2019
    Applicant: Genentech, Inc.
    Inventors: James John Crawford, Aleksandr Kolesnikov, Jianwen A. Feng
  • Compositions and methods for diagnosis and treatment of hepatic cancers
    Patent number: 10266602
    Abstract: The present invention relates to methods of treating liver cancer using a Notch signaling inhibitor. Compositions and methods for the treatment of liver cancers are also provided.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: April 23, 2019
    Assignee: Genentech, Inc.
    Inventors: Dorothy French, Erik Huntzicker, Christian W. Siebel
  • Anti-CLL-1 antibodies and immunoconjugates
    Patent number: 10266597
    Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: April 23, 2019
    Assignee: Genentech, Inc.
    Inventors: Bing Zheng, Andrew Polson, Cecilia Chiu, Wei-Ching Liang, Yan Wu
  • SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF
    Publication number: 20190112264
    Abstract: The invention provides compounds having the general formula I: (i) and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, ring B, R1, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
    Type: Application
    Filed: March 28, 2017
    Publication date: April 18, 2019
    Applicants: GENENTECH, INC., XENON PHARMACEUTICALS INC.
    Inventors: Sultan CHOWDHURY, Christoph Martin DEHNHARDT, Thilo FOCKEN, Michael Edward GRIMWOOD, Ivan William HEMEON, Steven MCKERRALL, Daniel SUTHERLIN
  • ANTI-TAU ANTIBODIES AND METHODS OF USE
    Publication number: 20190112361
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Application
    Filed: September 24, 2018
    Publication date: April 18, 2019
    Applicants: GENENTECH, INC., AC IMMUNE SA
    Inventors: Oskar Adolfsson, Gai Ayalon, Isidro Hotzel, Danielle Marie Di Cara
  • METHODS OF PRODUCING TWO CHAIN PROTEINS IN BACTERIA
    Publication number: 20190112368
    Abstract: Provided herein are methods of producing a polypeptide containing two chains, such as an antibody including a light chain and a heavy chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes.
    Type: Application
    Filed: September 21, 2018
    Publication date: April 18, 2019
    Applicant: Genentech, Inc.
    Inventors: James GIULIANOTTI, Dorothea E. REILLY
  • ANTI-TAU ANTIBODIES AND METHODS OF USE
    Publication number: 20190112362
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Application
    Filed: September 24, 2018
    Publication date: April 18, 2019
    Applicants: GENENTECH, INC., AC IMMUNE SA
    Inventors: Oskar Adolfsson, Gai Ayalon, Isidro Hotzel, Danielle Marie Di Cara
  • Therapeutic compounds and uses thereof
    Patent number: 10258603
    Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, Rc, and Rd have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: April 16, 2019
    Assignees: GENENTECH, INC., CONSTELLATION PHARMACEUTICALS, INC.
    Inventors: Brian K. Albrecht, Steven F. Bellon, Daniel J. Burdick, Alexandre Cote, Terry Crawford, Les A. Dakin, Vickie Hsiao-Wei Tsui, Michael Charles Hewitt, Yves LeBlanc, Steven R. Magnuson, Christopher G. Nasveschuk, F. Anthony Romero, Yong Tang, Alexander M. Taylor, Shumei Wang
  • Aryl sultam derivatives as RORc modulators
    Patent number: 10259808
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X1, X2, X3, X4, Y, Z, A, Het, R1, R2, R3, R4, R5 R6, R7, R8, R9, R10, R11, R12 and R13 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis, muscular sclerosis and psoriasis.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: April 16, 2019
    Assignee: Genentech, Inc.
    Inventors: Benjamin Fauber, Emanuela Gancia, Tammy Ladduwahetty, David Vesey, Paul Winship, Olivier Rene
  • Assisted manual injector devices and methods
    Patent number: 10252005
    Abstract: Various embodiments disclosed herein relate to needle-based injectors that incorporate a power assembly comprising a stored energy source and a rate control assembly. The power assembly may be further configured to allow the injection to be performed with more force than a user may be capable of delivering, while also allowing the user to maintain control of the injection process after the stored energy source has been released and the injection has begun, such the user may increase or decrease the rate of injection, or stop the injection, during the injection process. In various embodiments, the power assembly may comprise spring- or gas-based stored energy sources, and/or may comprise friction- or tension-based rate control assemblies. Described herein are also methods for injecting an agent using embodiments of the devices described here.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: April 9, 2019
    Assignee: GENENTECH, INC.
    Inventors: Gordon D. Row, Andrew I. Poutiatine, Neal Schlatter, Adrian Bischoff
  • Anti-Polyubiquitin Antibodies and Methods of Use
    Publication number: 20190100578
    Abstract: The invention provides anti-polyubiquitin antibodies and methods of using the same.
    Type: Application
    Filed: September 14, 2018
    Publication date: April 4, 2019
    Applicant: Genentech, Inc.
    Inventors: Vishva Dixit, Robert F. Kelley, Marissa L. Matsumoto
  • BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20190100530
    Abstract: The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
    Type: Application
    Filed: July 12, 2018
    Publication date: April 4, 2019
    Applicant: Genentech, Inc.
    Inventors: Snahel PATEL, Gregory HAMILTON, Guiling ZHAO, Huifen CHEN, Blake DANIELS, Craig STIVALA