Patents Assigned to Genentech
  • Anti-tigit antibodies and methods of use
    Patent number: 10017572
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: July 10, 2018
    Assignee: Genentech, Inc.
    Inventors: Jane L. Grogan, Robert J. Johnston, Yan Wu, Wei-Ching Liang, Patrick Lupardus, Mahesh Yadav, Dhaya Seshasayee, Meredith Hazen
  • PYRROLOBENZODIAZEPINE ANTIBODY DRUG CONJUGATES AND METHODS OF USE
    Publication number: 20180185486
    Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug moiety via a disulfide linker, pyrrolobenzodiazepine linker-drug intermediates, and methods of using the antibody-drug conjugates.
    Type: Application
    Filed: February 20, 2018
    Publication date: July 5, 2018
    Applicant: Genentech, Inc.
    Inventors: Peter Dragovich, Thomas Pillow, Jack Sadowsky, Mark X. Sliwkowski, BinQing Wei
  • Method for the reduction of host cell proteins in affinity chromatography
    Publication number: 20180186832
    Abstract: The current invention reports a method for purifying an antibody by reducing the content of a host cell protein. The method employs a wash step with a low conductivity aqueous solution in an affinity chromatography.
    Type: Application
    Filed: February 20, 2018
    Publication date: July 5, 2018
    Applicants: Genentech, Inc., Hoffmann-La Roche Inc
    Inventors: Paul MCDONALD, Richard ST. JOHN, Marc WONG, Roberto FALKENSTEIN, Wolfgang KOEHNLEIN, Klaus SCHWENDNER, Bernhard SPENSBERGER, Michael WIEDMANN, Frank ZETTL, Annika KLEINJANS, Carina KOPP, Benjamin TRAN, Ryan ERICKSON
  • Antibody formulations
    Patent number: 10010611
    Abstract: The invention provides stable aqueous pharmaceutical formulations comprising a therapeutic antibody, trehalose, a buffer, and optional surfactant, and having a pH in the range of about 5.5 to about 7.0. The invention also provides methods for making such formulations and methods of using such formulations.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: July 3, 2018
    Assignee: GENENTECH, INC.
    Inventors: Yatin Gokarn, Isidro E. Zarraga, Jonathan Zarzar, Thomas Patapoff
  • Biheteroaryl compounds and uses thereof
    Patent number: 10010549
    Abstract: The present invention provides for compounds of Formula I-I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula I-I all have the meaning as defined herein.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: July 3, 2018
    Assignee: Genentech, Inc.
    Inventors: Anthony Estrada, Liting Dong, Kevin X. Chen, Paul Gibbons, Malcolm Huestis, Terry Kellar, Wen Liu, Changyou Ma, Joseph Lyssikatos, Alan Olivero, Snahel Patel, Daniel Shore, Michael Siu
  • Antibodies directed to IL-17A/IL-17F heterodimers
    Patent number: 10011654
    Abstract: The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: July 3, 2018
    Assignee: Genentech, Inc.
    Inventors: David P. Arnott, Austin L. Gurney, Philip E. Hass, James M. Lee, Yan Wu
  • Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
    Patent number: 10011856
    Abstract: The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: July 3, 2018
    Assignee: Genentech, Inc.
    Inventors: Meixia Zhou, Bradley Richard Snedecor, Chi Kin Domingos Ng, Amy Shen
  • Anti-Jagged1 antibodies and methods of use
    Patent number: 10011661
    Abstract: The invention provides anti-Jagged1 antibodies and methods of using the same.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: July 3, 2018
    Assignee: Genentech, Inc.
    Inventors: Yvonne Chinn, Julie Q. Hang, Christian W. Siebel, Yan Wu
  • MULTISPECIFIC ANTIGEN-BINDING PROTEINS
    Publication number: 20180177873
    Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.
    Type: Application
    Filed: October 20, 2017
    Publication date: June 28, 2018
    Applicant: Genentech, Inc.
    Inventors: PAUL CARTER, CHRISTOPH SPIESS, YIYUAN YIN, JIANHUI ZHOU, WENDY SANDOVAL, JACOB CORN, MICHAEL DILLON
  • PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE
    Publication number: 20180179229
    Abstract: Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
    Type: Application
    Filed: February 26, 2018
    Publication date: June 28, 2018
    Applicants: GILEAD CONNECTICUT, INC., GENENTECH INC.
    Inventors: Antonio J.M. BARBOSA, Peter A. BLOMGREN, Kevin S. CURRIE, Ravi KRISHNAMOORTHY, Jeffrey E. KROPF, Seung H. LEE, Scott A. MITCHELL, Daniel ORTWINE, Aaron C. SCHMITT, Xiaojing WANG, Jianjun XU, Wendy YOUNG, Honglu ZHANG, Zhongdong ZHAO, Pavel E. ZHICHKIN
  • Polynucleotides encoding anti-Notch1 NRR antibody polypeptides
    Patent number: 10005844
    Abstract: The invention provides anti-Notch1 NRR antibodies, and compositions comprising and methods of using these antibodies.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: June 26, 2018
    Assignee: Genentech, Inc.
    Inventors: Christian W. Siebel, Yan Wu
  • Methods of treating PR-positive, luminal A breast cancer with PI3K inhibitor, pictilisib
    Patent number: 10004748
    Abstract: Methods and compositions are provided for treating breast cancer in patients with a PI3K inhibitor, GDC-0941 in combination with an endocrine therapy agent.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: June 26, 2018
    Assignee: Genentech, Inc.
    Inventors: Mika K. Derynck, Lori Friedman, Steven Brian Gendreau, Sandra Milan
  • Method of reducing blood glucose by administering RON agonists
    Patent number: 10005848
    Abstract: This invention relates to RON compositions, in particular RON composition comprising a RON agonist, and methods of using the compositions for the treatment of diseases. The invention also relates to diagnosis of RON-associated or MSP-associated diseases.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: June 26, 2018
    Assignee: GENENTECH, INC.
    Inventors: Jackson G Egen, Jo-Anne Hongo, Steven Kauder, Robert A Lazarus, Lydia Santell, Yan Wu, Meredith Hazen, Wei-Ching Liang
  • Therapeutic compounds and methods of use thereof
    Patent number: 10005724
    Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: June 26, 2018
    Assignees: GENENTECH, INC., XENON PHARMACEUTICALS INC.
    Inventors: Jean-Christophe Andrez, Philippe Bergeron, Paul Robert Bichler, Sultan Chowdhury, Christoph Martin Dehnhardt, Thilo Focken, Wei Gong, Michael Edward Grimwood, Abid Hasan, Ivan William Hemeon, Qi Jia, Brian Safina, Shaoyi Sun, Michael Scott Wilson, Alla Yurevna Zenova
  • HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
    Publication number: 20180169099
    Abstract: The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
    Type: Application
    Filed: August 7, 2017
    Publication date: June 21, 2018
    Applicants: Array BioPharma Inc., Genentech, Inc.
    Inventors: Ian S. Mitchell, James F. Blake, Rui Xu, Nicholas C. Kallan, Dengming Xiao, Keith Lee Spencer, Josef R. Bencsik, Eli M. Wallace, Stephen T. Schlachter, Anna L. Leivers, Jun Liang, Brian Safina, Birong Zhang, Christine Chabot, Steven Do
  • INHIBITORS OF RIP1 KINASE AND METHODS OF USE THEREOF
    Publication number: 20180170927
    Abstract: The invention provides novel compounds having RIP1 kinase inhibitory activity, pharmaceutical compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: December 12, 2017
    Publication date: June 21, 2018
    Applicant: Genentech, Inc.
    Inventors: Snahel Patel, Gregory Hamilton
  • METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND AN ANTI-CD20 ANTIBODY
    Publication number: 20180171025
    Abstract: The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an anti-CD20 antibody and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.
    Type: Application
    Filed: July 28, 2017
    Publication date: June 21, 2018
    Applicant: Genentech, Inc.
    Inventor: Jeong KIM
  • ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES
    Publication number: 20180169259
    Abstract: The invention provides anti-CD79b antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: June 21, 2017
    Publication date: June 21, 2018
    Applicant: Genentech Inc.
    Inventors: Paul Polakis, Andrew Polson, Susan Diane Spencer, Shang-Fan Yu
  • Anti-FGFR3 antibodies and methods using same
    Patent number: 10000571
    Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: June 19, 2018
    Assignee: Genentech, Inc.
    Inventors: Avi Ashkenazi, Jing Qing, Christian Wiesmann, Yan Wu
  • Antibody formulations
    Patent number: 10000562
    Abstract: Formulations comprising an anti-IL-13 antibody are provided, including pharmaceutical formulations and methods of using such formulations.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: June 19, 2018
    Assignee: GENENTECH, INC.
    Inventors: Ajay Deshmukh, Joumana Zeid, Thomas M. Scherer