Patents Assigned to Generex Pharmaceuticals Incorporated
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Patent number: 7687453Abstract: A mixed micellar pharmaceutical formulation includes a micellar pharmaceutical agent, an alkali metal C8 to C22 alkyl sulfate, alkali metal salicylate, a pharmaceutically acceptable edetate and at least one absorption enhancing compounds. The absorption enhancing compounds are selected from the group consisting of lecithin, hyaluronic acid, pharmaceutically acceptable salts of hyaluronic acid, octylphenoxypolyethoxyethanol, glycolic acid, lactic acid, chamomile extract, cucumber extract, oleic acid, linolenic acid, borage oil, evening primrose oil, trihydroxy oxo cholanylglycine, glycerine, polyglycerin, lysine, polylysine, triolein and mixtures thereof. Each absorption enhancing compound is present in a concentration of from 1 to 10 wt./wt. % of the total formulation, and the total concentration of absorption enhancing compounds are is less than 50 wt./wt. % of the formulation.Type: GrantFiled: March 3, 2003Date of Patent: March 30, 2010Assignee: Generex Pharmaceuticals IncorporatedInventor: Pankaj Modi
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Patent number: 7087215Abstract: Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and at least three different micelle-forming compounds as described in the specification. Micelle size ranges between about 1 and 10 nanometers. Methods for administering the compositions are also disclosed. A preferred method for administering the present composition is through the buccal region of the mouth, which has been demonstrated to achieve peak plasma levels of the pharmaceutical agent in about thirty minutes.Type: GrantFiled: August 16, 2002Date of Patent: August 8, 2006Assignee: Generex Pharmaceuticals IncorporatedInventor: Pankaj Modi
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Publication number: 20060067891Abstract: A metered dose spray device administers medicine contained therein to the buccal cavity within a user's mouth upon actuation of the device. A metered dose spray device comprising an insulin solution is also provided.Type: ApplicationFiled: February 1, 2002Publication date: March 30, 2006Applicant: Generex Pharmaceuticals IncorporatedInventor: Pankaj Modi
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Patent number: 6979668Abstract: A method of cleaning a metered dose spray device, and a cleaning composition for such cleaning, prevent the device from becoming clogged with medication. The method includes removing the aerosol can containing the medication from the actuator, placing an aerosol can containing a cleaning composition in the actuator, and dispensing the cleaning solution through the actuator. The residual medication is thereby removed from the actuator. A sufficiently small quantity of cleaning composition remains in the actuator so that the cleaning composition itself will not clog the actuator. Additionally, the cleaning composition is non-toxic, so that residual cleaning composition remaining in the actuator will not harm the user when a subsequent dose of medication is dispensed.Type: GrantFiled: December 16, 2002Date of Patent: December 27, 2005Assignee: Generex Pharmaceuticals IncorporatedInventor: Pankaj Modi
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Patent number: 6849263Abstract: Pharmaceutical compositions comprising a narcotic analgesic in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and other micelle-forming compounds as described in the specification. Micelle size ranges between about 1 and 10 nanometers. Methods for making and using the compositions are also disclosed. A preferred method for administering the present composition is through the buccal mucosa of the mouth.Type: GrantFiled: August 16, 2002Date of Patent: February 1, 2005Assignee: Generex Pharmaceutical IncorporatedInventor: Pankaj Modi
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Patent number: 6451286Abstract: Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and at least three different micelle-forming compounds as described in the specification. Micelle size ranges between about 1 and 10 nanometers. Methods for making and using the compositions are also disclosed. A preferred method for administering the present composition is through the buccal region of the mouth.Type: GrantFiled: May 19, 2000Date of Patent: September 17, 2002Assignee: Generex Pharmaceuticals IncorporatedInventor: Pankaj Modi
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Patent number: 6432383Abstract: A mixed micellar pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal lauryl sulphate, alkali metal salicylate, a pharmaceutically acceptable edetate and at least one absorption enhancing compounds. The absorption enhancing compounds are selected from the group consisting of lecithin, hyaluronic acid, pharmaceutically acceptable salts of hyaluronic acid, octylphenoxypolyethoxyethanol, glycolic acid, lactic acid, chamomile extract, cucumber extract, oleic acid, linolenic acid, borage oil, evening of primrose oil, trihydroxy oxo cholanylglycine, glycerin, polyglycerin, lysine, polylysine, triolein and mixtures thereof. The amount of each absorption enhancing compound is present in a concentration of from 1 to 10 wt./wt. % of the total formulation, and the total concentration of absorption enhancing compounds are less than 50 wt./wt. % of the formulation. A method for administering insulin to the buccal mucosa using a metered dose inhaler is also disclosed.Type: GrantFiled: March 30, 2000Date of Patent: August 13, 2002Assignee: Generex Pharmaceuticals IncorporatedInventor: Pankaj Modi
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Patent number: 6375975Abstract: Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and at least three different micelle-forming compounds as described in the specification. Micelle size ranges between about 1 and 10 nanometers. Methods for making and using the compositions are also disclosed. A preferred method for administering the present composition is through the buccal region of the mouth.Type: GrantFiled: March 6, 2000Date of Patent: April 23, 2002Assignee: Generex Pharmaceuticals IncorporatedInventor: Pankaj Modi
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Patent number: 6350432Abstract: A pharmaceutical composition solubilized in a propellant that can be administered buccally or to the lungs using a metered dose dispenser is provided. The composition comprises a pharmaceutical agent; glycerin and/or polyglycerin; phenol and/or methyl phenol; and at least one absorption enhancing compound. A pressurized container with the composition and a methods of making the composition are also provided.Type: GrantFiled: March 19, 1999Date of Patent: February 26, 2002Assignee: Generex Pharmaceuticals IncorporatedInventor: Pankaj Modi
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Patent number: 6350458Abstract: Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in micellar form are disclosed. The micelles are formed from an alkali metal alkyl sulfate, and at least one additional micelle-forming compound as described in the specification. An alkali metal salicylate and a pharmaceutically acceptable edetate are also included in the composition. Micelle size ranges between about 1 and 10 nanometers. Methods for making and using the compositions are also disclosed.Type: GrantFiled: April 6, 2000Date of Patent: February 26, 2002Assignee: Generex Pharmaceuticals IncorporatedInventor: Pankaj Modi
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Patent number: 6312665Abstract: A mixed micellar aerosol pharmaceutical formulation is provided. The formulation comprises a pharmaceutical agent, an alkali metal alkyl sulphate, at least three micelle-forming compounds, a phenol and a propellant. The propellant provides enchanced absorption of the pharmaceutical agent in the buccal region. A process of making and a method of administering the composition are also included.Type: GrantFiled: August 31, 1999Date of Patent: November 6, 2001Assignee: Generex Pharmaceuticals IncorporatedInventor: Pankaj Modi
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Patent number: 6221378Abstract: A mixed micellar pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an lkali metal C8 to C22 alkyl sulphate, alkali metal salicylate, a pharmaceutically acceptable edetate and at least one absorption enhancing compounds. The absorption enhancing compounds are selected from the group consisting of lecithin, hyaluronic acid, pharmaceutically acceptable salts of hyaluronic acid, octylphenoxypolyethoxyethanol, glycolic acid, lactic acid, chamomile extract, cucumber extract, oleic acid, linolenic acid, borage oil, evening of primrose oil, trihydroxy oxo cholanylglycine, glycerin, polyglycerin, lysine, polylysine, triolein and mixtures thereof. The amount of each absorption enhancing compound is present in a concentration of from 1 to 10 wt./wt. % of the total formulation, and the total concentration of absorption enhancing compounds are less than 50 wt./wt. % of the formulation.Type: GrantFiled: August 31, 1999Date of Patent: April 24, 2001Assignee: Generex Pharmaceuticals IncorporatedInventor: Pankaj Modi