Abstract: An object to provide a brake device for a caster that has a simple structure, provides reliable braking, has no risk of damaging the circumferential surface of a roller, and has high durability. The brake device for a caster includes: a plurality of projecting parts formed concentrically at regular intervals on opposite side-surfaces of a roller in a direction in parallel with the axis, and levers set across the roller at both side-panels of a fork so as to be opposed to the projecting parts, and a claw formed at a tip of each of the levers so as to be opposed to the projecting parts, wherein the levers are operated so that the claw is engaged with a concave part formed between the projecting parts, thereby locking rotation of the roller.

Abstract: A control method of controlling a computer to analyze, at a second facility, nucleic acid sequence data obtained, at a first facility, by a sequencer that reads a nucleic acid sequence, for a gene panel test, comprising receiving, from the first facility via a network, a sequence data set comprising a plurality of nucleic acid sequence data obtained by the sequencer corresponding to each of a plurality of library samples comprising a first library sample and a second library sample, which are prepared from a specimen of a subject, and link information indicating that the first library sample and the second library sample are prepared from the specimen of the same subject; analyzing a first sequence data and a second sequence data corresponding to each of the first library sample and the second library sample linked by the link information; and outputting analysis information based on an analysis result of the first sequence data and an analysis result of the second sequence data, is disclosed.

Abstract: Disclosed is a compound represented by formula (1) or a salt thereof wherein: “Base” represents an aromatic heterocyclic group which may have a substituent, or an aromatic hydrocarbon ring group which may have a substituent; A1 represents a single bond or an alkylene group; R1 to R5 represent an atom or a group disclosed in the specification.

Abstract: A method for testing for sensitivity of chemotherapy against colorectal cancer, the method using, as an indicator, methylation in at least one site selected from the group consisting of CpG sites comprised in regions (i) to (xvi) in DNA collected from a colorectal cancer patient (the regions (i) to (xvi) are as described herein).

Abstract: A method for detecting a genetic mutation is provided. The method comprising: carrying out PCR using a template DNA, a forward primer, a reverse primer and a wild-type oligonucleotide; and detecting an amplified DNA. In the method, the wild-type oligonucleotide comprises LNA or BNA, and on a DNA strand of the template, with which the wild-type oligonucleotide is hybridized, a region with which the wild-type oligonucleotide is a hybridized and a region with which the forward primer or the reverse primer is hybridized partially overlap each other, or the regions are separated from each other by 1 to 18 bases.

Abstract: A forward primer of a primer set in accordance with the present invention for detecting BLV is a mixture of (1) a first primer consisting of a polynucleotide including 15 or more successive bases including the 16th C in the base sequence of SEQ ID NO: 1 and (2) a second primer consisting of a plurality of kinds of polynucleotides including at least the first to 15th bases in the base sequence of SEQ ID NO: 2. Two or more of M, N, Y, K, and D which are included in the second primer are each a degenerate base which specifies two or more kinds of bases, and the second primer includes at least 10 kinds of polynucleotides including at least the first to 15th bases in the base sequences of SEQ ID NOs: 3 to 12.

Abstract: Detection method of a base mutation in a target base sequence of a nucleic acid sample, includes: performing a PCR reaction with the nucleic acid sample as a template, using a primer set capable of amplifying, by PCR, an amplification target region including the target base sequence; a blocker nucleic acid fragment having a base sequence complementary to the target base sequence and including a residue which is synthetic nucleic acid; and a probe that hybridizes to a region, in the target region, closer to a 5? end of the target region than the target base sequence in the same chain as the target base sequence, and that has a fluorescent substance on one of a 5? end and a 3? end of the probe and a quenching substance on the other; and measuring an amplification amount of the template in the PCR reaction by detecting fluorescence from the probe.

Abstract: A hybrid-type magnet includes an electromagnet having a U-shaped core made of a magnetic material. The core includes a core body having outer ends and a pair of opposing arms extending upwardly from the outer ends of the core body, wherein each opposing arm includes an upper end having an end surface. An excitation coil is wound on the core. The hybrid-type magnet also includes a bar-like engagement member including a permanent magnet having a direction of magnetization, the permanent magnet being disposed between magnetic members. The magnetic members are closely joined to the respective end surfaces of the arms, the permanent magnet being positioned between the arms of the core, whereby the end surfaces of the opposing arms extend in a direction substantially parallel to the direction of magnetization of the permanent magnet.