Abstract: Mature human serum albumin is produced from a human serum albumin produced by a microbiological route in the form of fused protein ("pseudo-pro-HSA") containing an N-terminal peptide elongation.
Type:
Grant
Filed:
February 8, 1991
Date of Patent:
February 16, 1993
Assignee:
Genetica
Inventors:
Martine Latta, Jean-Francois Mayaux, Paolo Sarmientos
Abstract: Mature human serum albumin is produced from a human serum albumin produced by a microbiological route in the form of fused protein ("pseudo-pro-HSA") containing an N-terminal peptide elongation.
Type:
Grant
Filed:
February 19, 1987
Date of Patent:
March 31, 1992
Assignee:
Genetica
Inventors:
Martine Latta, Jean-Francois Mayaux, Paolo Sarmientos
Abstract: Human serum albumin is made by culturing a bacterium (e.g. E. coli) capable of providing for the stable maintenance of a plasmid containing an inducible promoter (e.g. P.sub.trp), a ribosome binding site (e.g. that of the CII gene of bacteriophage lambda not containing the t.sub.R1 sequence), and the human serum albumin gene possessing an ATG initiation codon at the 5' end.
Type:
Grant
Filed:
December 13, 1989
Date of Patent:
August 6, 1991
Assignee:
Genetica
Inventors:
Michael Knapp, Georges Brefort, Paolo Sarmientos
Abstract: Human serum albumin is produced by culturing a bacterium (e.g. E. coli) capable of maintaining a plasmid containing an inducible promoter (e.g. P.sub.trp) upstream of the penicillin amidase promoter, the ribosome binding site of the penicillin amidase gene and the penicillin amidase signal peptide, fused with the structural gene for human serum albumin.
Type:
Grant
Filed:
March 25, 1986
Date of Patent:
April 3, 1990
Assignee:
Genetica
Inventors:
Michael Knapp, Georges Brefort, Martine Latta, Jean-Francois Mayaux, Paolo Sarmientos
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