Abstract: The present invention provides methods for attenuating gene expression in a cell using gene-targeted double stranded RNA (dsRNA). The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the “target” gene).
Type:
Application
Filed:
January 24, 2003
Publication date:
May 6, 2004
Applicants:
Genetica, Inc., Cold Spring Harbor Laboratory
Inventors:
David H. Beach, Emily Bernstein, Amy Caudy, Scott Hammond, Gregory J. Hannon, Patrick J. Paddison, Douglas Conklin