Abstract: Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The active growth factor is preferably a composition containing at least one bone morphogenetic protein and a suitable carrier. The method results in the regeneration of functional repair of articular cartilage tissue.
Type:
Grant
Filed:
January 28, 2000
Date of Patent:
April 27, 2004
Assignee:
Genetics Institute, LLC.
Inventors:
Renwen Zhang, Diane Peluso, Elisabeth Morris
Abstract: The use of interleukin-11 to prevent, to ameliorate, and to treat a gastrointestinal disorder in a mammal in need of such treatment is disclosed.
Type:
Grant
Filed:
August 1, 2001
Date of Patent:
April 20, 2004
Assignees:
Genetics Institute, LLC, Catholic University
Inventors:
James C. Keith, Jr., Theo L. Peeters, Inge Depoortere, G. Van Asche
Abstract: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
Type:
Grant
Filed:
August 31, 2001
Date of Patent:
April 13, 2004
Assignee:
Genetics Institute, LLC.
Inventors:
Anthony J. Celeste, John M. Wozney, Vicki A. Rosen, Neil M. Wolfman, Gerald H. Thomsen, Douglas A. Melton
Abstract: Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-&ggr; or TNF-&agr;. Suitable conditions for treatment include multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes melitis and autoimmune inflammatory eye disease.
Type:
Grant
Filed:
February 25, 2000
Date of Patent:
March 16, 2004
Assignee:
Genetics Institute, LLC
Inventors:
John Leonard, Samuel Goldman, Richard O'Hara, Jr.
Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
Type:
Application
Filed:
July 8, 2003
Publication date:
February 26, 2004
Applicant:
GENETICS INSTITUTE, LLC.
Inventors:
Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, David Merberg, Michael J. Agostino, Robert J. Steininger, Vikki Spaulding, Gordon G. Wong, Hilary F. Clark, Kim Fechtel, Cheryl Evans, Maurice Treacy
Abstract: Aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
Type:
Grant
Filed:
October 18, 2001
Date of Patent:
February 10, 2004
Assignee:
Genetics Institute, LLC
Inventors:
Lisa A. Racie, Natalie C. Twine, Michael J. Agostino, Neil Wolfman, Elisabeth A. Morris
Abstract: Methods are provided for purification of Factor VIII polypeptides by immunoaffinity chromatography and ion exchange chromatography, in which the eluate from the immunoaffinity column is diluted with a solution comprising higher salt concentration, or lower non-polar agent concentration than that of the elution solution, prior to passing the diluted solution through the ion exchange column. The methods result in improved purification without significant yield loss.
Type:
Grant
Filed:
December 29, 2000
Date of Patent:
January 27, 2004
Assignee:
Genetics Institute, LLC
Inventors:
Brian D. Kelley, Suresh Vunnum, Johanna Dalborg, Anna Petersson
Abstract: Methods are provided for treating or inhibiting the formation of tissue fibrosis using IL-13 antagonists, including without limitation soluble forms of the IL-13 receptor.
Type:
Grant
Filed:
November 29, 1999
Date of Patent:
December 16, 2003
Assignees:
Genetics Institute, LLC, The United States of America as represented by the Department
of Health and Human Services
Inventors:
Thomas A. Wynn, Monica G. Chiaramonte, Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew J. Whitters, Clive Wood
Abstract: The invention provides a novel calcium-independent cytosolic phospholipase A2/B enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.
Abstract: This invention provides substituted indole and indoline compounds useful in inhibiting phospholipase activity, particularly including cytosolic phospholipase A2 (cPLA2) activity, as well as pharmaceutical compositions containing the compounds and methods of using them to treat various maladies, including pain and inflammatory conditions.
Type:
Grant
Filed:
August 24, 2000
Date of Patent:
October 7, 2003
Assignee:
Genetics Institute LLC
Inventors:
Jasbir S. Seehra, Neelu Kaila, John C. McKew, Jean E. Bemis, YiBin Xiang, Lihren Chen
Abstract: Purified BMP-16 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-16 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
Abstract: Methods and compositions are provided for the treatment of periodontal disease and bone lesions. Preferred methods comprise administering a composition containing one or more osteogenic and/or ligament-inducing bone morphogenetic protein and a suitable carrier. The method results in the regeneration of alveolar bone in both a vertical and horizontal direction, and can result in the regeneration of bone, cementum and ligamentous structure between said regenerated bone and the tooth root surface, such that minimal ankylosis and root resorption results. The method and composition are useful for the repair of supraalveolar periodontal lesions and defects, mandibular and maxillary class II and III furcations and interproximal defects, and augmentation of the alveolar ridge of these structures.
Abstract: Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
Type:
Grant
Filed:
March 23, 2001
Date of Patent:
September 2, 2003
Assignee:
Genetics Institute, LLC
Inventors:
John M. Wozney, Elizabeth A. Wang, Vicki A. Rosen, Anthony J. Celeste
Abstract: Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding these proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to these BMP receptor proteins.
Type:
Grant
Filed:
June 5, 2001
Date of Patent:
August 26, 2003
Assignee:
Genetics Institute, LLC.
Inventors:
John M. Wozney, Anthony J. Celeste, R. Scott Thies, Noboru Yamaji
Abstract: Purified BMP-17 and BMP-18 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-17 and BMP-18 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, epithelium, brain, spleen, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
Abstract: Methods are disclosed for refolding proteins of the TGF-&bgr; family of proteins. The methods employ as refolding agents one or more compounds which are non-detergent zwitterionic compounds, such as sulfobetaines, substituted pyridines, substituted pyrroles and acid substituted aminocyclohexanes.
Abstract: Methods are disclosed for refolding proteins of the TGF-&bgr; family of proteins. The methods employ as refolding agents one or more compounds which are non-detergent zwitterionic compounds, such as sulfobetaines, substituted pyridines, substituted pyrroles and acid substituted aminocyclohexanes.
Abstract: Methods are disclosed for refolding proteins of the TGF-&bgr; family of proteins. The methods employ as refolding agents one or more compounds which are substituted pyridines.