Abstract: Provided is a composition preventing tissue adhesion and a method for preparing the same, and, more particularly, a composition preventing tissue adhesion which further contains a drug selectively inhibiting inflammatory response and a method for preparing the composition, in which the composition is produced through a chemical reaction by adding a cross-linking agent to an aqueous solution which contains a block copolymer containing a polyethyleneoxide block having the ability to suppress tissue adhesion, and a polymer with 10,000 to 1,000,000 g/mol of molecular weight which can be mixed with the copolymer; the composition is characterized in that the difference of viscosity, absorbance of visible rays region, and stability between the upper and lower liquid layers are within 10% when centrifuging the composition; and also the method for preparing the composition enhances cross-linking homogenization and viscosity stability through simultaneous spraying and stirring methods without a reaction retardant.
Type:
Grant
Filed:
September 17, 2009
Date of Patent:
August 4, 2015
Assignees:
Genewel Co., LTD, Hannam University Institute Industry-Academia Cooperation
Inventors:
Jin-suk Choi, Young-woo Lee, Yun-gee Lee, Jun-ho Kim, Jin-ho Lee
Abstract: Disclosed herein is a hyaluronic acid epoxide derivative film comprises a polymer containing a hydroxyl (—OH) terminal group. The film is prepared by allowing an epoxy crosslinker to react with a mixture of hyaluronic acid and a polymer containing a hydroxyl (—OH) terminal group and has improved physical strength, in vivo stability, flexibility, adhesiveness to biological tissue, and biocompatibility.
Type:
Application
Filed:
March 22, 2013
Publication date:
September 26, 2013
Applicant:
GENEWEL CO., LTD
Inventors:
Young Woo Lee, Wan Jin Cho, Ji Yeon Jang
Abstract: Provided is a thermosensitive composition preventing tissue adhesion and a method for preparing the same, and, more particularly, a thermosensitive composition preventing tissue adhesion which further contains a drug selectively inhibiting inflammatory response and a method for preparing the composition, in which the composition is produced through a chemical reaction by adding a cross-linking agent to an aqueous solution which contains a block copolymer containing a polyethyleneoxide block having the ability to suppress tissue adhesion, and a polymer with 10,000 to 1,000,000 g/mol of molecular weight which can be mixed with the copolymer; the composition is characterized in that the difference of viscosity, absorbance of visible rays region, and stability between the upper and lower liquid layers are within 10% when centrifuging the composition; and also the method for preparing the composition enhances cross-linking homogenization and viscosity stability through simultaneous spraying and stirring methods wi
Type:
Application
Filed:
September 17, 2009
Publication date:
September 22, 2011
Applicants:
GENEWEL CO., LTD, HANNAM UNIVERSITY INSTITUTE INDUSTRY-ACADEMIA COOPERATION
Inventors:
Jin-suk Choi, Young-woo Lee, Yun-gee Lee, Jun-ho Kim, Jin-ho Lee
Abstract: Provided is an encapsulated functional fine particle composition capable of spraying that is useful for hemostasis and wound protection and allows a patient to treat the wound by oneself. Additionally, the composition can be rapidly applied on a large wound during an operation using an air gun in case of in-vivo application and shows prompt hemostasis.
Type:
Application
Filed:
October 30, 2009
Publication date:
August 25, 2011
Applicant:
GENEWEL CO., LTD
Inventors:
Jin-suk Choi, Young-woo Lee, Jun-ho Kim, Eun-young Shim