Patents Assigned to Genfit
  • Patent number: 8461212
    Abstract: The invention concerns compositions comprising substituted 1,3-diphenylprop-2-en-1-one derivatives designed for therapeutic use. The inventive compositions are useful in particular for preventing or treating cardiovascular diseases, syndrome X, Ia restenosis, diabetes, obesity, hypertension, inflammatory diseases, cancers or neoplasms (benign or malignant tumors), neurodegenerative, dermatological diseases and disorders related to oxidative stress, for preventing or treating the effects of ageing in general and for example skin ageing, in particular in the field of cosmetics (occurrence of wrinkles and the like).
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: June 11, 2013
    Assignee: GENFIT
    Inventors: Jamila Najib, Karine Caumont-Bertrand
  • Publication number: 20130131372
    Abstract: The invention relates to methods for producing chalcone (1,3-diphenylprop-2-en-1-one) derivatives that have multiple substitutions on a phenyl ring. Intermediate chalcone derivatives are modified by Phase Transfer Catalysis (PTC) for introducing a substituted alkyl group that is provided by a sulfonic acid derivative on a phenyl ring already containing substituent groups on one or two carbon atoms adjacent to the carbon atom where a substituent group is being introduced. The methods of the invention allow producing efficiently, by either S-alkylation or O-alkylation, chalcones derivatives that are characterized for their biological activities that are intermediate compounds for producing molecules having such activities, or that can be used for generating libraries of compounds to be screened by means of in vitro and/or in vivo assays and establishing structure-activity relationships.
    Type: Application
    Filed: May 16, 2011
    Publication date: May 23, 2013
    Applicant: GENFIT
    Inventors: Karine Bertrand, Alice Roudot, Patrice Rool
  • Patent number: 8258182
    Abstract: The present invention involves substituted 1,3-diphenylpropane derivatives, pharmaceutical compositions comprising them and the therapeutic uses thereof, in particular in the fields of human and animal health.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: September 4, 2012
    Assignee: Genfit
    Inventors: Jean-François Delhomel, Rémy Hanf, Karine Caumont-Bertrand
  • Patent number: 8188148
    Abstract: The present invention concerns substituted 1,3-diphenylpropane derivatives, pharmaceutical compositions comprising them and the therapeutic uses thereof, particularly in the field of human and animal health.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: May 29, 2012
    Assignee: Genfit
    Inventors: Jean-François Delhomel, Rémy Hanf, Karine Caumont-Bertrand
  • Publication number: 20120129932
    Abstract: The invention concerns compositions comprising substituted 1,3-diphenylprop-2-en-1-one derivatives designed for therapeutic use. The inventive compositions are useful in particular for preventing or treating cardiovascular diseases, syndrome X, Ia restenosis, diabetes, obesity, hypertension, inflammatory diseases, cancers or neoplasms (benign or malignant tumors), neurodegenerative, dermatological diseases and disorders related to oxidative stress, for preventing or treating the effects of ageing in general and for example skin ageing, in particular in the field of cosmetics (occurrence of wrinkles and the like).
    Type: Application
    Filed: January 9, 2012
    Publication date: May 24, 2012
    Applicant: GENFIT
    Inventors: Jamila NAJIB, Karine Caumont-Bertrand
  • Patent number: 8106097
    Abstract: The invention concerns compositions comprising substituted 1,3-diphenylprop-2-en-1-one derivatives designed for therapeutic use. The inventive compositions are useful in particular for preventing or treating cardiovascular diseases, syndrome X, Ia restenosis, diabetes, obesity, hypertension, inflammatory diseases, cancers or neoplasms (benign or malignant tumors), neurodegenerative, dermatological diseases and disorders related to oxidative stress, for preventing or treating the effects of ageing in general and for example skin ageing, in particular in the field of cosmetics (occurrence of wrinkles and the like).
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: January 31, 2012
    Assignee: Genfit
    Inventors: Jamila Najib, Karine Caumont-Bertrand
  • Patent number: 8058308
    Abstract: The invention concerns novel substituted 1,3-diphenylprop-2-en-1-one derivatives, pharmaceutical compositions comprising same, their therapeutic uses, in particular for treating cerebral ischemia. The invention also concerns a method for preparing said derivatives.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: November 15, 2011
    Assignee: Genfit
    Inventors: Jamila Najib, Karine Caumont-Bertrand
  • Patent number: 8048900
    Abstract: The invention concerns the treatment of obesity, in particular abdominal visceral obesity. More specifically, the invention concerns the use of selective 15-lipoxygenase (LO) inhibitors for preparing medicines useful in the treatment of obesity, or at least abdominal visceral obesity, and/or its consequences.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: November 1, 2011
    Assignee: Genfit S.A.
    Inventors: Geneviève Martin, Sébastien Barradeau, Sakina Sayah-Jeanne
  • Publication number: 20110190515
    Abstract: The invention concerns novel substituted 1,3-diphenylprop-2-en-1-one derivatives, pharmaceutical compositions comprising same, their therapeutic uses, in particular for treating cerebral ischemia. The invention also concerns a method for preparing said derivatives.
    Type: Application
    Filed: April 11, 2011
    Publication date: August 4, 2011
    Applicant: GENFIT
    Inventors: Jamila NAJIB, Karine Caumont-Bertrand
  • Patent number: 7943661
    Abstract: The invention concerns novel substituted 1,3-diphenylprop-2-en-1-one derivatives, pharmaceutical compositions comprising same, their therapeutic uses, in particular for treating cerebral ischemia. The invention also concerns a method for preparing said derivatives.
    Type: Grant
    Filed: July 8, 2003
    Date of Patent: May 17, 2011
    Assignee: Genfit
    Inventors: Jamila Najib, Karine Caumont-Bertrand
  • Publication number: 20100286276
    Abstract: The present invention concerns substituted 1,3-diphenylpropane derivatives, pharmaceutical compositions comprising them and the therapeutic uses thereof, particularly in the field of human and animal health.
    Type: Application
    Filed: June 21, 2007
    Publication date: November 11, 2010
    Applicant: GENFIT
    Inventors: Jean-Fancois Delhomel, Rémy Hanf, Karine Caumont-Bertrand
  • Publication number: 20100120909
    Abstract: The invention concerns compositions comprising substituted 1,3-diphenylprop-2-en-1-one derivatives designed for therapeutic use. The inventive compositions are useful in particular for preventing or treating cardiovascular diseases, syndrome X, Ia restenosis, diabetes, obesity, hypertension, inflammatory diseases, cancers or neoplasms (benign or malignant tumors), neurodegenerative, dermatological diseases and disorders related to oxidative stress, for preventing or treating the effects of ageing in general and for example skin ageing, in particular in the field of cosmetics (occurrence of wrinkles and the like).
    Type: Application
    Filed: October 30, 2009
    Publication date: May 13, 2010
    Applicant: GENFIT
    Inventors: Jamila Najib, Karine Caumont-Bertrand
  • Publication number: 20100004159
    Abstract: The present invention relates to polysubstituted imidazolone derivatives, to the pharmaceutical compositions comprising them and to the therapeutic uses thereof in the human and animal health fields. The present invention also relates to a process for preparing these derivatives.
    Type: Application
    Filed: July 24, 2007
    Publication date: January 7, 2010
    Applicant: GENFIT
    Inventors: Edith Bouey, Christophe Masson, Karine Bertrand
  • Patent number: 7632870
    Abstract: The invention concerns compositions comprising substituted 1,3-diphenylprop-2-en-1-one derivatives designed for therapeutic use. The inventive compositions are useful in particular for preventing or treating cardiovascular diseases, syndrome X, Ia restenosis, diabetes, obesity, hypertension, inflammatory diseases, cancers or neoplasms (benign or malignant tumors), neurodegenerative, dermatological diseases and disorders related to oxidative stress, for preventing or treating the effects of ageing in general and for example skin ageing, in particular in the field of cosmetics (occurrence of wrinkles and the like).
    Type: Grant
    Filed: July 8, 2003
    Date of Patent: December 15, 2009
    Assignee: Genfit
    Inventors: Jamila Najib, Karine Caumont-Bertrand
  • Patent number: 7566737
    Abstract: The invention concerns novel substituted 1,3-diphenylprop-2-en-1-one derivatives and combinations of said derivatives with other therapeutically active ingredients. The invention also concerns compositions comprising said derivatives or said combinations and uses thereof, for the treatment of cerebrovascular diseases, pathology related to inflammation, neurodegeneration, deregulations of lipid and/or glucose metabolism, cell proliferation and/or differentiation and/or skin or central nervous system ageing.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: July 28, 2009
    Assignee: Genfit
    Inventors: Jean-François Delhomel, Karine Caumont-Bertrand
  • Patent number: 7547729
    Abstract: The invention relates to substituted 1,3-diphenylprop-2-en-1-one derivative compounds, pharmaceutical and/or cosmetic compositions containing same, and the applications thereof in therapeutics and cosmetics. The invention also relates to a method for preparing said derivatives.
    Type: Grant
    Filed: January 7, 2005
    Date of Patent: June 16, 2009
    Assignee: Genfit
    Inventors: Karine Caumont-Bertrand, Jean-François Delhomel
  • Patent number: 7547543
    Abstract: The present invention concerns a method for identifying substances useful for treating inflammation, characterized in that it comprises the following steps: (a) placing said substance in contact with a nucleic acid construct containing the Retinoid-Related Orphan Receptor (ROR) receptor response element of the promoter of the I?B? gene, under conditions suitable for allowing said substance to bind to said response element, (b) measuring the possible binding of said substance to the response element or the transcriptional activity of the response element or of a promoter containing it, (c) optionally comparing the measurement of step (b) with a measurement carried out under conditions similar to those of steps (a) and (b) but with a nucleic acid construct containing the mutated response element.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: June 16, 2009
    Assignee: Genfit
    Inventors: Bart Staels, Philippe Delerive
  • Publication number: 20090060905
    Abstract: The invention concerns the treatment of obesity, in particular abdominal visceral obesity. More specifically, the invention concerns the use of selective 15-lipoxygenase (LO) inhibitors for preparing medicines useful in the treatment of obesity, or at least abdominal visceral obesity, and/or its consequences.
    Type: Application
    Filed: July 30, 2008
    Publication date: March 5, 2009
    Applicant: Genfit
    Inventors: Genevieve Martin, Sebastien Barradeau, Sakina Sayah-Jeanne
  • Publication number: 20080207540
    Abstract: The invention relates to methods and compounds which can modulate reverse cholesterol transport in a mammal and to screening methods enabling the selection, identification and/or characterization of compounds which can modulate reverse cholesterol transport. The invention also relates to cells, vectors and genetic constructs which can be used to implement said methods, in addition to pharmaceutical compositions intended for the treatment of atherosclerosis. The inventive methods are based on the use of LRH-1 response elements derived from the apo AI gene promoter.
    Type: Application
    Filed: December 23, 2004
    Publication date: August 28, 2008
    Applicant: Genfit
    Inventor: Bart Staels
  • Patent number: 7385082
    Abstract: The invention relates to a method for the preparation of de 1,3-diphenylprop-2-en-1-one substituted on one of the two phenyl groups by a carboxyalkyloxy group or a carboxyalkylthio group.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: June 10, 2008
    Assignee: GENFIT
    Inventors: Jean-François Delhomel, Karine Caumont-Bertrand